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11 条记录 (耗时 0.019 秒)

    Derivatives of 6-bromo penicillanic acid
    1.
    发明授权
    Derivatives of 6-bromo penicillanic acid 失效
    6-溴青霉烷酸的衍生物

    公开(公告)号：US4340539A

    公开(公告)日：1982-07-20

    申请号：US214833

    申请日：1980-12-11

    申请人： William J. Gottstein

    发明人： William J. Gottstein

    IPC分类号： C07D499/00

    CPC分类号： C07D499/00

    摘要： 2.beta.-Chloromethyl-2.alpha.-methylpenam-3.alpha.-carboxylic acid sulfone and salts and esters thereof were synthesized and found to be potent inhibitors of .beta.-lactamases.

    摘要翻译： 合成了2β-氯甲基-2α-甲基亚胺-3α-羧酸砜及其盐和酯，发现其是β-内酰胺酶的有效抑制剂。

    7-Cyclizedamino-3-heterothiomethyl cephalosporin derivatives
    2.
    发明授权
    7-Cyclizedamino-3-heterothiomethyl cephalosporin derivatives 失效
    7-环化氨基-3-异硫代甲基头孢菌素衍生物

    公开(公告)号：US4091213A

    公开(公告)日：1978-05-23

    申请号：US758229

    申请日：1977-01-10

    申请人： Murray A. Kaplan ,  William J. Gottstein ,  Alphonse P. Granatek

    发明人： Murray A. Kaplan ,  William J. Gottstein ,  Alphonse P. Granatek

    IPC分类号： A61K31/545 ,  C07D501/58 ,  C07D501/36

    CPC分类号： A61K31/545 ,  C07D501/58

    摘要： Compounds of the formula ##STR1## wherein A is hydrogen, hydroxy, methyl or methoxy,R.sup.1 is hydrogen, sodium or potassium,R.sup.2 is carboxyl or 2-furyl or an aliphatic, aromatic or heterocyclic radical to which there is also attached a strongly acidic group in the form of its sodium or potassium salt, andR.sup.3 is tetrazol-5-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazol-2-yl, 1,3,4-oxadiazol-3-yl or 1,2,4-triazol-5-yl, each of such groups being unsubstituted or substituted with one or two lower alkyl groups of one to four carbon atoms are prepared by reacting the appropriate aldehyde with the corresponding amphoteric cephalosporin. Preferred products have the structure ##STR2## in which A is --H or --SO.sub.3 Na.

    摘要翻译： 式Ⅰ化合物其中A是氢，羟基，甲基或甲氧基，R 1是氢，钠或钾，R 2是羧基或2-呋喃基或脂族，芳族或杂环基团， 其钠盐或钾盐形式的酸性基团，R 3为四唑-5-基，1,2,4-噻二唑-5-基，1,3,4-噻二唑-2-基，1,3,4 - 恶二唑-3-基或1,2,4-三唑-5-基，每个这些基团是未取代的或被一个或两个1-4个碳原子的低级烷基取代，通过使适当的醛与相应的 两性头孢菌素。 优选的产品具有其中A为-H或-SO 3 Na的结构。

    Cephalosporins derivatives 7-cyclized .alpha.-amino-3-heterothio
    9.
    发明授权
    Cephalosporins derivatives 7-cyclized .alpha.-amino-3-heterothio 失效
    头孢菌素衍生物7-环化{60-氨基-3-异硫代

    公开(公告)号：US4064345A

    公开(公告)日：1977-12-20

    申请号：US745034

    申请日：1976-11-26

    申请人： Murray A. Kaplan ,  William J. Gottstein ,  Alphonse P. Granatek

    发明人： Murray A. Kaplan ,  William J. Gottstein ,  Alphonse P. Granatek

    IPC分类号： A61K31/545 ,  C07D501/58 ,  C07D501/36

    CPC分类号： A61K31/545 ,  C07D501/58

    摘要： Compounds of the formula ##STR1## wherein A is hydrogen, hydroxy, methyl or methoxy,R.sup.1 is hydrogen, sodium or potassium,R.sup.2 is carboxyl or 2-furyl or an aliphatic, aromatic or heterocyclic radical to which there is also attached a strongly acidic group in the form of its sodium or potassium salt, andR.sup.3 is tetrazol-5-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazol-2-yl, 1,3,4-oxadiazol-3-yl or 1,2,4-triazol-5-yl, each of such groups being unsubstituted or substituted with one or two lower alkyl groups of one to four carbon atoms are prepared by reacting the appropriate aldehyde with the corresponding amphoteric cephalosporin. Preferred products have the structure ##STR2## in which A is --H or --SO.sub.3 Na.

    摘要翻译： 式I的化合物其中A是氢，羟基，甲基或甲氧基，R 1是氢，钠或钾，R 2是羧基或2-呋喃基或脂族，芳族或杂环基，其中还附着了 其钠盐或钾盐形式的酸性基团，R 3为四唑-5-基，1,2,4-噻二唑-5-基，1,3,4-噻二唑-2-基，1,3,4 - 恶二唑-3-基或1,2,4-三唑-5-基，每个这些基团是未取代的或被一个或两个1-4个碳原子的低级烷基取代，通过使适当的醛与相应的 两性头孢菌素。 优选的产品具有其中A为-H或-SO 3 Na的结构 + tr 。

    Derivatives of 7-(cyclized)phenylglycyl-3-triazolo-thio methyl cephalosporin
    10.
    发明授权
    Derivatives of 7-(cyclized)phenylglycyl-3-triazolo-thio methyl cephalosporin 失效
    7-（环化）苯基甘氨酰-3-三唑并硫代甲基头孢菌素的衍生物

    公开(公告)号：US4061862A

    公开(公告)日：1977-12-06

    申请号：US654314

    申请日：1976-02-02

    申请人： Murray A. Kaplan ,  William J. Gottstein ,  Alphonse P. Granatek

    发明人： Murray A. Kaplan ,  William J. Gottstein ,  Alphonse P. Granatek

    IPC分类号： A61K31/545 ,  C07D501/36

    CPC分类号： A61K31/545 ,  C07D501/58

    摘要： Compounds of the formula ##STR1## wherein A is hydrogen, hydroxy, methyl or methoxy,R.sup.1 is hydrogen, sodium or potassium, andR.sup.2 is 1,2,3-triazol-5-yl, such group being unsubstituted or substituted with one or two lower alkyl groups of one to four carbon atoms are prepared by reacting the appropriate aldehyde with the corresponding amphoteric cephalosporin. A preferred product has the structure ##STR2##

    摘要翻译： 式Ⅰ的化合物，其中A是氢，羟基，甲基或甲氧基，R 1是氢，钠或钾，R 2是1,2,3-三唑-5-基，该基团是未被取代的或被一个 或两个具有1-4个碳原子的低级烷基通过使适当的醛与相应的两性头孢菌素反应来制备。 优选的产品具有结构