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公开(公告)号：US5911757A
公开(公告)日：1999-06-15
申请号：US478232
申请日：1995-06-07
CPC分类号： A61M39/0247 , A61F2/0013 , A61F2/12
摘要： The methods and apparatus of the present invention permit stable transcutaneous access. Some preferred embodiments of the invention provide body pocket access channels that provide stable means for communicating between the exterior of the body and a natural or created internal body pocket. Other embodiments involve the inclusion of an attachment elements surrounding a device sought to be passed from a location external of a patient's body to a location within the body at the exit site, but which are attached to the device at a location within the body rather than at the exact location where the device passes through a patient's skin, thereby forming a body pocket that will reduce stress or strain at the exit site. Several alternative embodiments for effecting body pockets through use of attachment elements are disclosed.
摘要翻译： 本发明的方法和装置允许稳定的经皮通路。 本发明的一些优选实施例提供身体口袋通道，其提供用于在身体的外部与天然或创建的内部身体口袋之间进行通信的稳定手段。 其他实施例涉及包括围绕设备的附接元件，所述设备被试图从患者身体外部的位置传送到出口位置处的身体内的位置，但是在身体内的位置处附接到设备，而不是 在设备穿过患者皮肤的确切位置处，从而形成将减少出口部位处的压力或应变的身体口袋。 公开了通过使用附接元件来实现身体口袋的几个替代实施例。
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公开(公告)号：US5971961A
公开(公告)日：1999-10-26
申请号：US082979
申请日：1998-05-21
CPC分类号： A61M25/04 , A61M2025/0233
摘要： This invention relates to methods and apparatus for making and using noded cuffs on transcutaneous or intrabody prosthetic devices, such as catheters, to effect improved stability of the prosthesis/tissue opening site interface. In particular, the noded cuff apparatus of the present invention provides for positioning of the tissue opening site in a manner which facilitates more rapid establishment of a stably biointegrated and well-healed prosthesis/tissue opening site interface. In addition, in accord with the methods of the present invention, non-biointegrated portions of the noded cuff can be simply and easily removed from the underlying prosthetic device to facilitate maintenance of the stably biointegrated interface. Preferably, this removal takes place after a period of time during which the interface has become stably established. In accord with the methods and apparatus of the present invention, thus, infections or healing difficulties at the prosthesis/tissue opening site interface are greatly reduced and a more comfortable and stable interface is more rapidly established and more easily maintained.
摘要翻译： 本发明涉及用于制造和使用经皮或体内假体装置（例如导管）上的编织箍的方法和装置，以改善假体/组织开口部位界面的稳定性。 特别地，本发明的编织袖带装置以便于更快速地建立稳定的生物整合和良好愈合的假体/组织开放位置界面的方式来提供组织开口部位的定位。 此外，根据本发明的方法，可以简单且容易地从下面的假体装置移除编织的袖带的非生物整合部分，以便维持稳定的生物整合界面。 优选地，该去除在接口稳定建立的一段时间之后进行。 根据本发明的方法和装置，因此，假体/组织开口位置界面处的感染或愈合困难大大降低，并且更快速地建立和更容易地保持更舒适和稳定的界面。
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公开(公告)号：US4798195A
公开(公告)日：1989-01-17
申请号：US928539
申请日：1986-11-07
IPC分类号： A61B17/02
CPC分类号： A61B17/02
摘要： A moldable, weighted, surgical retractor and methods for its use. The surgical retractor comprises a generally flat plate having a plurality of protrusions or arms extending outwardly from the interior body of the plate. Included around the periphery of the plate and the arms are a plurality of slots. The slots may be of any size and shape and function to hold surgical stays in place during the surgical procedure. The arms or protrusions of the present invention may be placed in a variety of positions so that stays may hold certain portions of the surgical site in any desired direction. For example, arms or protrusions of the present invention may be lifted upwardly and stays may be connected to the upwardly extending arms. As a result, upward lifting forces may be directed into the surgical site to hold blood vessels, tendons, bones or other structural features upward within the surgical area. In addition, the arms of the retractor may be molded around a portion of the patient's anatomy in order to hold it in place. The present invention is also directed to a system which includes the retractor of the present invention along with surgical stays of varying elastic properties and diameters. As a result, the force which the stays exert on a surgical area can be finely adjusted and chosen as desired by the surgeon.
摘要翻译： 一种可模制的加权手术牵开器及其使用方法。 手术牵开器包括具有从板的内部主体向外延伸的多个突起或臂的大致平板。 包括在板的周边周围，并且臂是多个槽。 狭槽可以具有任何尺寸和形状并且在外科手术过程中将手术停留在适当位置的功能。 本发明的臂或突起可以放置在各种位置，使得支柱可以将手术部位的某些部分保持在任何期望的方向。 例如，本发明的臂或突起可以向上提起，并且支柱可以连接到向上延伸的臂。 结果，向上的提升力可以被引导到外科手术部位以在外科手术区域内向上保持血管，腱，骨骼或其他结构特征。 此外，牵开器的臂可以围绕患者解剖结构的一部分模制，以将其保持在适当的位置。 本发明还涉及一种包括本发明的牵开器以及具有变化的弹性和直径的手术支架的系统。 结果，可以根据外科医生的需要精细地调整和选择停留在手术区域上的力。
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公开(公告)号：US5759204A
公开(公告)日：1998-06-02
申请号：US789597
申请日：1997-01-24
CPC分类号： A61M39/0247 , A61F2/12
摘要： The methods and apparatus of the present invention permit a stable body pocket to be formed utilizing multiple biocompatible sheets or using only a single biocompatible sheet positioned to create either a potential space or actual space stable body pocket. The sheets have one surface which permits tissue ingrowth and thereby stably secures the sheet in the desired position. The other sheet surface is non-adhering such that adherence to a facing surface does not occur thereby creating a stable body pocket. In addition, a stable body pocket can be formed by using a biocompatible sheet or sheets having a surface that is selectively capable of permitting tissue ingrowth such that some portions of the surface grows into the surrounding tissue and other portions of the surface do not adhere to the surrounding tissue. In this manner, the stable body pocket apparatus has flexible surface portions. Stable body pocket access channels can also be formed according to the methods and apparatus of the present invention. Such access channels can provide stable means for communicating between the exterior of the body and a natural or created internal body pocket. A method for forming a stable body pocket utilizing fluid pressure introduced into the space where a body pocket is desired is also in accord with the present invention.
摘要翻译： 本发明的方法和装置允许使用多个生物相容性片材形成稳定的身体口袋，或仅使用定位成产生潜在空间或实际空间稳定的身体口袋的单个生物相容性片材。 片材具有允许组织向内生长的一个表面，从而将片材稳定地固定在期望的位置。 另一个片材表面是不粘附的，使得不会发生与面对表面的附着，从而形成稳定的身体口袋。 此外，可以通过使用具有选择性地允许组织向内生长的表面的生物相容性片材或片材形成稳定的身体口袋，使得表面的一些部分生长到周围组织中，并且表面的其它部分不粘附到 周围的组织。 以这种方式，稳定体袋装置具有柔性的表面部分。 也可以根据本发明的方法和装置形成稳定的身体口腔通道。 这种进入通道可以提供用于在身体的外部和自然或创建的内部身体口袋之间进行通信的稳定手段。 使用引入到需要身体口袋的空间中的流体压力形成稳定的身体口袋的方法也符合本发明。
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公开(公告)号：US5681572A
公开(公告)日：1997-10-28
申请号：US156675
申请日：1993-11-22
摘要： A method of preparing a device of a selected material to have pores and pore interconnections of predetermined sizes and shapes includes the steps of forming a selectively removable open-celled porous mold form of particles which adhere to one another, with the particles corresponding to the predetermined pore sizes and shapes, and interconnections between the particles which bind them together in the form in which the connections correspond to the predetermined sizes and shapes of the pore connections. Also included are the steps of filling the vacancies between the particles and connections of the form with the selected material, and then removing the form to leave the selected material. The resulting device is at least partly porous, the pores and pore interconnections corresponding in size and shape to the particles and connections respectively.
摘要翻译： 制备具有预定尺寸和形状的孔和孔互连件的所选材料的装置的方法包括以下步骤：形成选择性可移除的开孔多孔模具形式的颗粒，其彼此粘附，颗粒对应于预定的 孔径和形状以及将它们结合在一起的颗粒之间的连接，其中连接对应于孔连接的预定尺寸和形状。 还包括填充颗粒之间的空位和形式与所选材料的连接的步骤，然后移除形式以留下所选择的材料。 所得到的装置至少部分是多孔的，孔和孔互连的尺寸和形状分别对应于颗粒和连接。
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公开(公告)号：US5605693A
公开(公告)日：1997-02-25
申请号：US475210
申请日：1995-06-07
摘要： The present invention is directed to methods of making a porous device utilizing at least one removable open-cell porous mold form comprising particles formed and shaped into a solidified mass of continuously interconnected particles defining continuously interconnected pores and connecting interstices. The primary mold form is made from a selected material comprising particles having predetermined sizes and shapes which is capable of forming a stable mold form under selected conditions and of being removed under selected conditions. The primary mold form can be used to mold a porous device directly or to mold a secondary mold form. Similarly, the secondary mold form can be used to mold a porous device directly or to mold a tertiary mold form. Depending on the number of mold forms used, the porous device contains pores and pore interconnections corresponding to either the continuously interconnected particles, or to the continuously interconnected pores.
摘要翻译： 本发明涉及制造多孔装置的方法，所述多孔装置利用至少一个可移除的开孔多孔模具形式，其包括形成并成形为固定的连续互连的颗粒的固定质量的颗粒，所述连续互连的颗粒限定连续互连的孔和连接间隙。 初级模具由包含具有预定尺寸和形状的颗粒的选定材料制成，其能够在选择的条件下形成稳定的模具并且在选择的条件下被去除。 初级模具可用于直接模制多孔装置或模制二次模具形式。 类似地，二次模具形式可以用于直接模制多孔装置或模制第三模具形式。 取决于使用的模具形式的数量，多孔装置包含对应于连续相互连接的颗粒或连续相互连接的孔的孔和孔互连。
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公开(公告)号：US5589176A
公开(公告)日：1996-12-31
申请号：US477409
申请日：1995-06-07
摘要： The present invention is directed to methods of forming doubly porous devices having a first porous portion with continuously interconnected pores and a second porous portion with continuously interconnected pores utilizing at least one removable open-cell porous mold form. The mold form is made from a selected material comprising particles having predetermined sizes and shapes which is capable of forming a stable mold form under selected conditions and of being removed under selected conditions. At least one stable coating layer is molded from the mold form to define a membrane separating the first porous portion and the second porous portion of said device. Alternatively, two different materials can be molded with the mold form into a doubly porous device comprising interlocked materials.
摘要翻译： 本发明涉及形成具有连续相互连通的孔的第一多孔部分和具有连续相互连通的孔的第二多孔部分的双重多孔装置的方法，利用至少一个可拆卸的开孔多孔模具形式。 模具形式由包括具有预定尺寸和形状的颗粒的选定材料制成，其能够在选定的条件下形成稳定的模具并且在选定的条件下被去除。 从模具形成至少一个稳定的涂层以限定分离所述装置的第一多孔部分和第二多孔部分的膜。 或者，可以将两种不同的材料用模具模制成包括互锁材料的双重多孔装置。
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公开(公告)号：US20090062633A1
公开(公告)日：2009-03-05
申请号：US12264835
申请日：2008-11-04
申请人： James H. Brauker , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , Jack C. Fisher , William J. Seare, JR. , Paul V. Neale
发明人： James H. Brauker , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , Jack C. Fisher , William J. Seare, JR. , Paul V. Neale
IPC分类号： A61B5/1473
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/6882
摘要： An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
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公开(公告)号：US5833664A
公开(公告)日：1998-11-10
申请号：US729813
申请日：1996-10-08
CPC分类号： A61M25/04 , A61M2025/0233
摘要： This invention relates to methods and apparatus for making and using noded cuffs on transcutaneous or intrabody prosthetic devices, such as catheters, to effect improved stability of the prosthesis/tissue opening site interface. In particular, the noded cuff apparatus of the present invention provides for positioning of the tissue opening site in a manner which facilitates more rapid establishment of a stably biointegrated and well-healed prosthesis/tissue opening site interface. In addition, in accord with the methods of the present invention, non-biointegrated portions of the noded cuff can be simply and easily removed from the underlying prosthetic device to facilitate maintenance of the stably biointegrated interface. Preferably, this removal takes place after a period of time during which the interface has become stably established. In accord with the methods and apparatus of the present invention, thus, infections or healing difficulties at the prosthesis/tissue opening site interface are greatly reduced and a more comfortable and stable interface is more rapidly established and more easily maintained.
摘要翻译： 本发明涉及用于制造和使用经皮或体内假体装置（例如导管）上的编织箍的方法和装置，以改善假体/组织开口部位界面的稳定性。 特别地，本发明的编织袖带装置以便于更快速地建立稳定的生物整合和良好愈合的假体/组织开放位置界面的方式来提供组织开口部位的定位。 此外，根据本发明的方法，可以简单且容易地从下面的假体装置移除编织的袖带的非生物整合部分，以便维持稳定的生物整合界面。 优选地，该去除在接口稳定建立的一段时间之后进行。 根据本发明的方法和装置，因此，假体/组织开口位置界面处的感染或愈合困难大大降低，并且更快速地建立和更容易地保持更舒适和稳定的界面。
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公开(公告)号：US5624674A
公开(公告)日：1997-04-29
申请号：US487964
申请日：1995-06-07
摘要： The present invention is directed to apparatus and methods for forming open-cell porous mold forms to mold porous devices having substantially continuously interconnected pores. The mold form is made from selected material comprising particles having predetermined sizes and shapes which is capable of forming a stable mold form under selected conditions. The particles are treated such that the particles are manipulable into a mass of continuously interconnected particles defining continuously interconnected pores and connecting interstices within the mass. The formed mass is made into a predetermined shape and solidified to form a mold form.
摘要翻译： 本发明涉及用于形成开孔多孔模具形状以用于模制具有基本连续相互连通的孔的多孔装置的装置和方法。 模具形式由包括具有预定尺寸和形状的颗粒的选定材料制成，其能够在选定的条件下形成稳定的模具形状。 处理颗粒使得颗粒可操纵成大量连续互连的颗粒，其限定连续互连的孔和连接质量块内的间隙。 将形成的物料制成预定形状并固化以形成模具形式。
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