公开(公告)号：US09149219B2

公开(公告)日：2015-10-06

申请号：US13024076

申请日：2011-02-09

申请人： Paul V. Goode, Jr. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

发明人： Paul V. Goode, Jr. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC分类号： A61B5/05 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/145

CPC分类号： A61B5/7203 ,  A61B5/0004 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/08

摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

摘要翻译： 用于最小化或消除由于非葡萄糖速率限制现象（如缺血，pH变化，温度变化等）引起的瞬时非葡萄糖相关信号噪声的系统和方法。 系统监测来自葡萄糖传感器的数据流，并检测具有比电子或扩散相关系统噪声更高的幅度的信号伪像。 该系统连续地或间歇地替代一些或整个数据流，包括特别地解决瞬态信号伪影的信号估计方法。 该系统还能够检测信号伪像的严重性并且响应于信号伪像的严重性选择性地应用一个或多个信号估计算法因子，其包括选择性地将不同的参数集合应用于信号估计算法或选择性地应用不同信号 估计算法。

公开(公告)号：US08821400B2

公开(公告)日：2014-09-02

申请号：US13023776

申请日：2011-02-09

申请人： Paul V. Goode, Jr. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

发明人： Paul V. Goode, Jr. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC分类号： A61B5/7203 ,  A61B5/0004 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/08

摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

公开(公告)号：US08346338B2

公开(公告)日：2013-01-01

申请号：US13014910

申请日：2011-01-27

申请人： Paul V. Goode, Jr. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

发明人： Paul V. Goode, Jr. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： A61B5/7203 ,  A61B5/0004 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/08

摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

摘要翻译： 用于最小化或消除由于非葡萄糖速率限制现象（如缺血，pH变化，温度变化等）引起的瞬时非葡萄糖相关信号噪声的系统和方法。 系统监测来自葡萄糖传感器的数据流，并检测具有比电子或扩散相关系统噪声更高的幅度的信号伪像。 该系统连续地或间歇地替代一些或整个数据流，包括特别地解决瞬态信号伪影的信号估计方法。 该系统还能够检测信号伪像的严重性并且响应于信号伪像的严重性选择性地应用一个或多个信号估计算法因子，其包括选择性地将不同的参数集合应用于信号估计算法或选择性地应用不同信号 估计算法。

公开(公告)号：US08292810B2

公开(公告)日：2012-10-23

申请号：US13015245

申请日：2011-01-27

申请人： Paul V. Goode, Jr. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

发明人： Paul V. Goode, Jr. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC分类号： A61B5/00

CPC分类号： A61B5/7203 ,  A61B5/0004 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/08

摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

摘要翻译： 用于最小化或消除由于非葡萄糖速率限制现象（如缺血，pH变化，温度变化等）引起的瞬时非葡萄糖相关信号噪声的系统和方法。 系统监测来自葡萄糖传感器的数据流，并检测具有比电子或扩散相关系统噪声更高的幅度的信号伪像。 该系统连续地或间歇地替代一些或整个数据流，包括特别地解决瞬态信号伪影的信号估计方法。 该系统还能够检测信号伪像的严重性并且响应于信号伪像的严重性选择性地应用一个或多个信号估计算法因子，其包括选择性地将不同的参数集合应用于信号估计算法或选择性地应用不同信号 估计算法。

公开(公告)号：US08255033B2

公开(公告)日：2012-08-28

申请号：US11410392

申请日：2006-04-25

申请人： James Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria Carr-Brendel ,  James H. Brauker

发明人： James Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria Carr-Brendel ,  James H. Brauker

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： A61B5/1473 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/14735 ,  A61B5/14865

摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

公开(公告)号：US08255030B2

公开(公告)日：2012-08-28

申请号：US11410555

申请日：2006-04-25

申请人： James Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria Carr-Brendel ,  James H. Brauker

发明人： James Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria Carr-Brendel ,  James H. Brauker

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： A61B5/1473 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/14735 ,  A61B5/14865

摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

公开(公告)号：US20110270062A1

公开(公告)日：2011-11-03

申请号：US13181341

申请日：2011-07-12

申请人： Paul V. Goode, JR. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

发明人： Paul V. Goode, JR. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC分类号： A61B5/145

CPC分类号： A61B5/7203 ,  A61B5/0004 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/08

摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

公开(公告)号：US20110125410A1

公开(公告)日：2011-05-26

申请号：US13014929

申请日：2011-01-27

申请人： Paul V. Goode, JR. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

发明人： Paul V. Goode, JR. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC分类号： G06F19/00 ,  G01N33/48

CPC分类号： A61B5/7203 ,  A61B5/0004 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/08

摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

公开(公告)号：US20110124997A1

公开(公告)日：2011-05-26

申请号：US13014910

申请日：2011-01-27

申请人： Paul V. Goode, JR. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

发明人： Paul V. Goode, JR. ,  James H. Brauker ,  Apurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC分类号： A61B5/00

CPC分类号： A61B5/7203 ,  A61B5/0004 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2562/0247 ,  A61B2562/0271 ,  A61B2562/08

摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

摘要翻译： 用于最小化或消除由于非葡萄糖速率限制现象（如局部缺血，pH变化，温度变化等）引起的瞬时非葡萄糖相关信号噪声的系统和方法。 系统监测来自葡萄糖传感器的数据流，并检测具有比电子或扩散相关系统噪声更高的幅度的信号伪像。 该系统连续地或间歇地替代一些或整个数据流，包括特别地解决瞬态信号伪影的信号估计方法。 该系统还能够检测信号伪像的严重性并且响应于信号伪像的严重性选择性地应用一个或多个信号估计算法因子，其包括选择性地将不同的参数集合应用于信号估计算法或选择性地应用不同信号 估计算法。

公开(公告)号：US07881763B2

公开(公告)日：2011-02-01

申请号：US11415631

申请日：2006-05-02

申请人： James H. Brauker ,  Victoria Carr-Brendel ,  Paul V. Neale ,  Laura A. Martinson ,  Mark A. Tapsak

发明人： James H. Brauker ,  Victoria Carr-Brendel ,  Paul V. Neale ,  Laura A. Martinson ,  Mark A. Tapsak

IPC分类号： A61B5/1473

CPC分类号： A61B5/6882 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/415 ,  A61B5/418 ,  A61B2562/187

摘要： An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.

摘要翻译： 一种用于测量体液中诸如葡萄糖的分析物的浓度的植入式传感器，其包括具有适于在所述传感器和所述体液之间输送分析物的感测区域的身体，其中所述感测区域位于弯曲部分上 使得当异物体胶囊围绕传感器形成时，异物胶囊朝向感测区域施加收缩力。 身体部分或完全弯曲，部分或完全覆盖有用于支撑组织向内生长的锚固材料，并被设计用于皮下组织植入。 几何设计，包括曲率，形状和其他因素最大限度地减少传感区域的慢性炎症反应，并有助于改善体内传感器的性能。