公开(公告)号：US3991067A

公开(公告)日：1976-11-09

申请号：US415342

申请日：1973-11-13

申请人： Gordon Ian Gregory ,  William Kingston Warburton ,  Peter William Seale

发明人： Gordon Ian Gregory ,  William Kingston Warburton ,  Peter William Seale

IPC分类号： C07D271/06

CPC分类号： C07D271/06

摘要： 1,2,4-Oxadiazoles having as 3- and 5-substituents a hydrogen atom, an aliphatic, cycloaliphatic, araliphatic, aryl or heterocyclic group, or a carbamoyl group of the formula -- CONR.sup.1 R.sup.2 where R.sup.1 & R.sup.2 which can be the same or different, are hydrogen atoms or aliphatic, cycloaliphatic, araliphatic or aryl groups or, taken with the N atom, a heterocvolic ring; provided that at least one of the 3- or 5-substituents is an N-substituted carbamoyl group. Antimicrobial activity, and particularly antiviral, antiparasitic and antibacterial activity is shown in this group. The corresponding oxadiazolins are also described and are useful intermediates in the preparation of the oxadiazoles.

摘要翻译： 具有3-和5-取代基的1,2,4-恶二唑具有氢原子，脂族，脂环族，芳脂族，芳基或杂环基或式-C CONR1R2的氨基甲酰基，其中R 1和R 2可以相同或 不同的是氢原子或脂族，脂环族，芳脂族或芳基，或者与N原子一起是杂环; 条件是3-或5-取代基中的至少一个是N-取代的氨基甲酰基。 该组显示抗菌活性，特别是抗病毒，抗寄生虫和抗菌活性。 还描述了相应的恶二唑啉，并且是制备恶二唑的有用的中间体。

公开(公告)号：US4012377A

公开(公告)日：1977-03-15

申请号：US556324

申请日：1975-03-07

申请人： John Anthony Claisse ,  Gordon Ian Gregory ,  William Kingston Warburton

发明人： John Anthony Claisse ,  Gordon Ian Gregory ,  William Kingston Warburton

IPC分类号： C07C45/74 ,  C07C47/24 ,  C07C259/14 ,  C07D271/06 ,  C07D271/07 ,  C07D333/24 ,  C07D333/28

CPC分类号： C07D271/06 ,  C07C259/14 ,  C07C317/00 ,  C07C323/00 ,  C07C45/74 ,  C07C47/24 ,  C07D271/07 ,  C07D333/24 ,  C07D333/28

摘要： There are described new compounds of formula ##STR1## in which E is selected from the group consisting of residues of formula ##STR2## in which R" is selected from the group consisting of amino, vinyl, allyl, ethynyl, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, or C.sub.1 -C.sub.5 alkylthio or a C.sub.1 -C.sub.5 alkyl group susbstituted by at least one halogen atom; and hydrogen; in which R.sup.1 and R.sup.2 are each selected from the group consisting of hydrogen, halogen, methyl and ethyl; and R' is selected from substituted phenyl when R" is other than hydrogen, and phenyl, thienyl and substituted phenyl and thienyl when R" is hydrogen.The compounds are useful in the control of parasites.Certain of the compounds have antimicrobial properties.

摘要翻译： 描述了新的式“IMAGE”化合物，其中E选自由下式组成的组：IMAGE＆gt;＆lt; IMAGE＆gt;其中R“选自氨基，乙烯基，烯丙基，乙炔基， C 1 -C 5烷基，C 1 -C 5烷氧基或C 1 -C 5烷硫基或被至少一个卤素原子取代的C 1 -C 5烷基; 和氢; 其中R 1和R 2各自选自氢，卤素，甲基和乙基; 当R“不是氢时，R'选自取代的苯基，当R”是氢时，R'选自苯基，噻吩基和取代的苯基和噻吩基。