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    Treatment of premenstrual syndrome and menopause
    2.
    发明授权
    Treatment of premenstrual syndrome and menopause 有权
    治疗经前期综合征和绝经期

    公开(公告)号：US06613792B1

    公开(公告)日：2003-09-02

    申请号：US09365425

    申请日：1999-08-02

    申请人： Suzanne R. Ellenberger ,  William P. Ellenberger ,  G. Merrill Andrus

    发明人： Suzanne R. Ellenberger ,  William P. Ellenberger ,  G. Merrill Andrus

    IPC分类号： A61K31405

    CPC分类号： A61K31/407 ,  A61K31/4035 ,  A61K31/7056

    摘要： A method of treating premenstrual syndrome and menopausal symptoms in a patient, the method comprising: administering to the patient an 1H-indole-3-methanol compound (e.g., 1H-indole-3-methanol; ascorbigen) in a medically acceptable manner in a pharmaceutically effective amount. It has been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly relieves the symptoms of PMS. Patients with PMS have reported decreased menstrual cramping, decreased menstrual flow, shorter duration of menses, decreased fatigue, less frequent headaches, improved mood, and decreased bloating resulting from the oral administration each day or during specific portions of the menstrual cycle of pharmaceutically effective amounts of dietary indoles derived from 1H-indole-3-methanol. It has also been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly relieves the symptoms of menopause.

    摘要翻译： 一种治疗患者经前期综合征和绝经期症状的方法，所述方法包括：以医学上可接受的方式向患者施用1H-吲哚-3-甲醇化合物（例如，1H-吲哚-3-甲醇;抗坏血酸） 药学有效量。 已经发现，这种吲哚，特别是1H-吲哚-3-甲醇的给药大大减轻了PMS的症状。 患有PMS的患者报告月经周期减少，月经流量减少，月经持续时间缩短，疲劳减轻，头痛减轻，情绪改善，口气恶化，以及口服给药每天或在月经周期的特定部分期间药物有效量 的衍生自1H-吲哚-3-甲醇的膳食吲哚。 还发现这种吲哚，特别是1H-吲哚-3-甲醇的给药大大减轻了更年期症状。