公开(公告)号：US06613792B1

公开(公告)日：2003-09-02

申请号：US09365425

申请日：1999-08-02

申请人： Suzanne R. Ellenberger ,  William P. Ellenberger ,  G. Merrill Andrus

发明人： Suzanne R. Ellenberger ,  William P. Ellenberger ,  G. Merrill Andrus

IPC分类号： A61K31405

CPC分类号： A61K31/407 ,  A61K31/4035 ,  A61K31/7056

摘要： A method of treating premenstrual syndrome and menopausal symptoms in a patient, the method comprising: administering to the patient an 1H-indole-3-methanol compound (e.g., 1H-indole-3-methanol; ascorbigen) in a medically acceptable manner in a pharmaceutically effective amount. It has been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly relieves the symptoms of PMS. Patients with PMS have reported decreased menstrual cramping, decreased menstrual flow, shorter duration of menses, decreased fatigue, less frequent headaches, improved mood, and decreased bloating resulting from the oral administration each day or during specific portions of the menstrual cycle of pharmaceutically effective amounts of dietary indoles derived from 1H-indole-3-methanol. It has also been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly relieves the symptoms of menopause.

摘要翻译： 一种治疗患者经前期综合征和绝经期症状的方法，所述方法包括：以医学上可接受的方式向患者施用1H-吲哚-3-甲醇化合物（例如，1H-吲哚-3-甲醇;抗坏血酸） 药学有效量。 已经发现，这种吲哚，特别是1H-吲哚-3-甲醇的给药大大减轻了PMS的症状。 患有PMS的患者报告月经周期减少，月经流量减少，月经持续时间缩短，疲劳减轻，头痛减轻，情绪改善，口气恶化，以及口服给药每天或在月经周期的特定部分期间药物有效量 的衍生自1H-吲哚-3-甲醇的膳食吲哚。 还发现这种吲哚，特别是1H-吲哚-3-甲醇的给药大大减轻了更年期症状。

公开(公告)号：US5895787A

公开(公告)日：1999-04-20

申请号：US954995

申请日：1997-10-08

申请人： Kathleen Arffmann ,  G. Merrill Andrus

发明人： Kathleen Arffmann ,  G. Merrill Andrus

IPC分类号： A61K31/404 ,  A61K31/407 ,  A61K33/06 ,  A61K33/40 ,  A61K31/405

CPC分类号： A61K33/40 ,  A61K31/404 ,  A61K31/407 ,  A61K33/06 ,  A61K36/02

摘要： A method of treating fibromyalgia-like complaints (i.e., fibromyalgia, chronic fatigue syndrome and irritable bowel syndrome) in a patient, the method comprising: administering to the patient an 1H-indole-3-methanol compound (e.g., 1H-indole-3-methanol, ascorbigen, bis(3-indolyl) methane, indolo�3,2-b(carbazole)!, 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, 5,6,11,12,17,18-hexahydrocyclonona�, 1,2-b;4,5-b';7,8-b"!triindole, 1H-indol-3-yl methoxy methane, ethoxy 1H-indol-3-yl ethoxy methane, other ethers of 1H-indole-3-methanol) in a medically acceptable manner in a pharmaceutically effective amount on a regular basis. It has been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly mitigates the most severe symptoms of fibromyalgia. Patients with fibromyalgia have reported a decrease in pain, less fatigue, improved sleep patterns, and an improved sense of well being resulting from the oral administration of pharmaceutically effective amounts of an 1H-indole-3-methanol compound each day.

摘要翻译： 一种治疗患者的纤维肌痛症状（即纤维肌痛，慢性疲劳综合征和肠易激综合征）的方法，所述方法包括：向患者施用1H-吲哚-3-甲醇化合物（例如1H-吲哚-3 - 甲醇，抗坏血酸，双（3-吲哚基）甲烷，吲哚并[3,2-b（咔唑）]，2-（吲哚-3-基甲基）-3,3'-二吲哚基甲烷，5,6,11,12， 17,18-六氢环磷酰胺[1,2-b; 4,5-b'; 7,8-b“]三吲哚，1H-吲哚-3-基甲氧基甲烷，乙氧基-1H-吲哚-3-基乙氧基甲烷 ，1H-吲哚-3-甲醇的其它醚）以医学上可接受的方式，以有效量的量定期进行。 已经发现，这种吲哚，特别是1H-吲哚-3-甲醇的给药大大减轻了最严重的纤维肌痛症状。 纤维肌痛患者报告每日口服给药药物有效量的1H-吲哚-3-甲醇化合物时疼痛减轻，疲劳减轻，睡眠模式改善，以及改善的口感。