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1.发明申请Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy 有权用于组合RF诱导的高热和放射免疫治疗的系统和方法公开(公告)号：US20050273143A1
公开(公告)日：2005-12-08
申请号：US11050478
申请日：2005-02-03
CPC分类号： A61K41/0052 , A61N1/403 , A61N1/406 , A61N5/1001 , B82Y5/00
摘要： A combined radiotherapy and hyperthermia therapy is provided, including inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Biomolecules labeled with at least one radionuclide suitable for radiotherapy are provided and introduced into a patient; targeted RF absorption enhancers are provided and introduced into a patient; and a hyperthermia generating RF signal is directed via toward the target cells, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells. Biomolecules labeled with at least one radionuclide suitable for radiotherapy may be used for both radiotherapy and as RF absorption enhancers for the hyperthermia generating RF signal.
摘要翻译： 提供了联合放疗和高热疗法，包括在目标区域的至少一部分（例如肿瘤或部分肿瘤或靶向癌细胞）中诱导高热。 提供用至少一种适用于放射治疗的放射性核素标记的生物分子并将其引入患者体内; 提供靶向RF吸收增强剂并将其引入患者体内; 并且通过朝向靶细胞引导产生高热的RF信号，从而加热与靶细胞结合的放射性核素标记的生物分子和靶向RF吸收增强剂。 靶向RF吸收增强剂可以以说话的方式将一个或多个RF吸收频率添加到目标区域中的细胞，这将允许产生以该频率或频率的RF信号以加热靶细胞的热疗。 用适合于放射治疗的至少一种放射性核素标记的生物分子可以用于放射治疗，也可以用作RF热吸收增强剂，用于产生高热的RF信号。
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2.发明申请Systems and methods for RF-induced hyperthermia using biological cells and nanoparticles as RF enhancer carriers 审中-公开使用生物细胞和纳米颗粒作为RF增强载体的RF诱导的热疗的系统和方法公开(公告)号：US20050251234A1
公开(公告)日：2005-11-10
申请号：US11050481
申请日：2005-02-03
CPC分类号： A61K41/0052 , A61N1/403 , A61N1/406 , A61N5/1001 , B82Y5/00
摘要： A method of inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Targeted RF absorption enhancers, e.g., tumor infiltrating lymphocytes (TILs) containing RF absorbing particles, are introduced into a patient. These targeted RF absorption enhancers will target certain cells in the target areas and enhance the effect of a hyperthermia generating RF signal directed toward the target area. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells.
摘要翻译： 提供了在目标区域的至少一部分（例如肿瘤或肿瘤部分或靶向癌细胞）中诱导高热的方法。 靶向RF吸收增强剂，例如含有RF吸收颗粒的肿瘤浸润淋巴细胞（TIL）被引入患者体内。 这些靶向RF吸收增强剂将靶向目标区域中的某些细胞并且增强产生针对靶区域的RF热信号产生的热疗效果。 靶向RF吸收增强剂可以以说话的方式将一个或多个RF吸收频率添加到目标区域中的细胞，这将允许产生以该频率或频率的RF信号以加热靶细胞的热疗。
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