公开(公告)号：US20180327427A1

公开(公告)日：2018-11-15

申请号：US16042920

申请日：2018-07-23

申请人： Lahjavida, LLC

发明人： James J. Krutak ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

IPC分类号： C07F1/00 ,  A61K49/00 ,  A61K41/00 ,  C09B23/08 ,  C09B23/01 ,  A61N1/40

CPC分类号： C07F1/00 ,  A61K41/0052 ,  A61K41/0057 ,  A61K49/0032 ,  A61K49/0093 ,  A61N1/406 ,  C09B23/0016 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/086

摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[S—CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.

公开(公告)号：US09901742B2

公开(公告)日：2018-02-27

申请号：US13103638

申请日：2011-05-09

申请人： Michel Marc

发明人： Michel Marc

IPC分类号： A61N1/40

CPC分类号： A61N1/403 ,  A61N1/406

摘要： An apparatus and method for heating a treatment region of a subject via the application of an alternating electric field is disclosed. The method includes positioning a treatment region of a subject between a first electrode and a second electrode sized to extend across the treatment region. The first and second electrodes are connected to a generator operable to apply an alternating electric field between the electrodes at a frequency in the range of 1 MHz to 100 MHz. The method also includes activating the generator to apply the alternating electric field between the first and second electrodes and across the treatment region. The alternating electric field causes movement of polar molecules in the treatment region whereby friction resulting from this molecular movement translates into heat throughout the treatment region.

公开(公告)号：US20170354344A1

公开(公告)日：2017-12-14

申请号：US15539193

申请日：2015-12-17

申请人： KONINKLIJKE PHILIPS N.V.

发明人： INGO SCHMALE ,  BERNARD GLEICH ,  TIMO FREDERIK SATTEL

IPC分类号： A61B5/05 ,  A61B5/00 ,  A61N1/40 ,  A61N2/02

CPC分类号： A61B5/0515 ,  A61B5/4836 ,  A61N1/406 ,  A61N2/02

摘要： The present invention relates to a cabling arrangement and a coil apparatus for use in an MPI apparatus to increase the sensitivity of the apparatus. The cabling arrangement comprises a first AC terminal (320), a second AC terminal (330), wherein said first and second AC terminals are configured for coupling an AC voltage between them, a first internal terminal (301), a second internal terminal (302), wherein said first and second internal terminals are configured for coupling a DC voltage between them, a first subset of one or more first conductors (401) coupled between the first internal terminal and the second AC terminal, and a second subset of one or more second conductors (402) coupled between the second internal terminal and the second AC terminal, wherein said first and second conductors are arranged to form a coil (125, 126, 127; 601, 602, 603, 604) to generate a magnetic field in a zone of interest.

公开(公告)号：US20170265803A1

公开(公告)日：2017-09-21

申请号：US15617440

申请日：2017-06-08

申请人： NIMD LTD.

发明人： Anan COPTY

IPC分类号： A61B5/00 ,  A61K41/00 ,  A61B18/08 ,  A61B5/055 ,  A61B18/18

CPC分类号： A61K41/0052 ,  A61B5/0062 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/0515 ,  A61B18/1815 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00732 ,  A61B2018/00785 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00845 ,  A61N1/406 ,  A61N5/025 ,  A61N5/04

摘要： The present disclosure provides devices, systems and methods for hyperthermia cancer treatment by supplying ferromagnetic nanoparticles to a target area having or suspected of having cancer cells, the ferromagnetic nanoparticles are configured to attach to the cancer cells and heat by absorbing magnetic energy, and radiating the target area with microwaves such that the target area is within a nearfield range of the radiated microwave, and the microwave radiation nearfield is magnetically biased such that the ratio of magnetic energy to electric energy is greater than 1.

公开(公告)号：US20170157253A1

公开(公告)日：2017-06-08

申请号：US15433018

申请日：2017-02-15

申请人： NANOBACTERIE

发明人： Edouard ALPHANDERY ,  Stéphanie FAURE ,  Imène CHEBBI

IPC分类号： A61K41/00 ,  A61K33/26 ,  A61K9/10 ,  A61K35/74 ,  A61K9/51 ,  A61K9/00

CPC分类号： A61N1/406 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/51 ,  A61K9/5146 ,  A61K33/26 ,  A61K35/74 ,  A61K41/0052 ,  A61N2/00 ,  C12N1/20 ,  C12N1/38

摘要： A method for the treatment of tumor(s), tumor cell(s), cancer(s) in a subject by the generation of heat. The latter is produced by chains of magnetosomes extracted from whole magnetotactic bacteria and subjected to an alternating magnetic field. These chains of magnetosomes yield efficient antitumoral activity whereas magnetosomes unbound from the chains or kept within the whole bacteria produce poor or no antitumoral activity. The introduction of various chemicals such as chelating agents and/or transition metals within the growth medium of the bacteria improves the heating properties of the chains of magnetosomes. Moreover, the insertion of the chains of magnetosomes within a lipid vesicle is also suggested in order to favor their rotation in vivo and hence to improve their heating capacity. The vesicle can contain an antitumoral agent together with the chains of magnetosomes, and the agent is released within the tumors by heating the vesicle.

公开(公告)号：US20170086734A1

公开(公告)日：2017-03-30

申请号：US14864195

申请日：2015-09-24

申请人： Elwha LLC

发明人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Dennis J. Rivet ,  Lowell L. Wood, JR.

IPC分类号： A61B5/00 ,  A61B5/01 ,  A61B46/00 ,  A61N5/02 ,  A61N2/00 ,  A61F7/00 ,  A61B5/055

CPC分类号： A61B5/4836 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/026 ,  A61B5/055 ,  A61B5/0816 ,  A61B5/6846 ,  A61B18/14 ,  A61B46/40 ,  A61B2018/00791 ,  A61B2034/104 ,  A61F7/007 ,  A61F2007/0096 ,  A61F2007/0242 ,  A61F2007/0255 ,  A61N1/403 ,  A61N1/406 ,  A61N5/025

摘要： Embodiments disclosed herein are directed to systems and methods for treating hypothermia in a subject is disclosed. In an embodiment, a method includes determining or measuring a temperature of a target region of the subject. The method also includes responsive to determining or measuring the temperature, directing electromagnetic energy at an external surface of the target region of the subject effective to heat the target region to a temperature of less than an ablation temperature of the target region.

公开(公告)号：US20170027424A1

公开(公告)日：2017-02-02

申请号：US15226991

申请日：2016-08-03

申请人： Gearbox, LLC

发明人： Bran Ferren ,  W. Daniel Hillis ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Thomas J. Nugent, JR. ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC分类号： A61B1/04 ,  A61B5/07 ,  A61B5/145 ,  A61B1/00 ,  A61B5/00 ,  A61B5/01

CPC分类号： A61B1/041 ,  A61B1/00156 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/0071 ,  A61B5/01 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/03 ,  A61B5/062 ,  A61B5/07 ,  A61B5/073 ,  A61B5/076 ,  A61B5/082 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4064 ,  A61B5/411 ,  A61B5/418 ,  A61B5/4839 ,  A61B5/6852 ,  A61B7/00 ,  A61B10/0045 ,  A61B10/04 ,  A61B17/22 ,  A61B17/22012 ,  A61B18/20 ,  A61B34/73 ,  A61B2010/0077 ,  A61B2010/0225 ,  A61B2017/00022 ,  A61B2017/00345 ,  A61F2/82 ,  A61N1/406 ,  A61N7/00 ,  G16H40/67

摘要： Methods of controlling the operation of a device traveling in a body tube tree, including sensing parameters from possible directions of travel and selecting the direction of travel based on the sensed parameters, implemented with a control system located partially or fully on the lumen traveling device. Various actions can be performed by the device for, e.g., medical or therapeutic purposes. Machine-readable media including instructions for performing the methods are also described.

摘要翻译： 控制在体管树中行进的装置的操作的方法，包括从可能的行进方向感测参数以及基于所感测的参数来选择行进方向，所述方法由部分地或完全位于流明行进装置上的控制系统实现。 可以通过该设备执行各种动作，例如医疗或治疗目的。 还描述了包括用于执行方法的指令的机器可读介质。

公开(公告)号：US09504745B2

公开(公告)日：2016-11-29

申请号：US14100892

申请日：2013-12-09

申请人： The Board of Regents of the University of Oklahoma

发明人： Roger G. Harrison, Jr. ,  Daniel E. Resasco ,  Luis Filipe Ferreira Neves

IPC分类号： A61K41/00 ,  A61N1/40 ,  A61K38/17 ,  A61K45/06 ,  A61K47/48 ,  B82Y5/00 ,  A61N2/02 ,  A61N5/06

CPC分类号： A61K41/0052 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/48215 ,  A61K47/48246 ,  A61K47/48869 ,  A61K47/48884 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6925 ,  A61K47/6929 ,  A61N1/406 ,  A61N2/02 ,  A61N5/062 ,  A61N2005/0659 ,  B82Y5/00 ,  A61K2300/00

摘要： Compositions for detecting and/or destroying cancer tumors and/or cancer cells via photodynamic therapy are disclosed, as well as methods of use thereof. The compositions comprise a linking protein or peptide attached to or otherwise physically associated with a carbon nanotube to form a targeted protein-carbon nanotube complex.

摘要翻译： 公开了通过光动力疗法检测和/或破坏癌肿瘤和/或癌细胞的组合物，以及其使用方法。 组合物包含与碳纳米管连接或以其他方式物理相联系的连接蛋白或肽，以形成靶向的蛋白质 - 碳纳米管复合物。

公开(公告)号：US20160271274A1

公开(公告)日：2016-09-22

申请号：US15035012

申请日：2014-11-07

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： ROBERT IVKOV ,  LAUREN WOODARD ,  MARTIN G. POMPER

IPC分类号： A61K49/18 ,  A61B5/00 ,  A61B6/03 ,  A61K49/08 ,  A61K9/50 ,  A61K9/51 ,  A61K41/00 ,  A61K49/04 ,  A61B5/055 ,  A61N5/10

CPC分类号： A61K49/183 ,  A61B5/0066 ,  A61B5/055 ,  A61B6/032 ,  A61B18/04 ,  A61B18/28 ,  A61B2018/00321 ,  A61B2018/00529 ,  A61F2007/009 ,  A61F2007/0098 ,  A61K9/5094 ,  A61K9/5115 ,  A61K9/5192 ,  A61K41/0052 ,  A61K49/0423 ,  A61K49/0428 ,  A61K49/08 ,  A61N1/406 ,  A61N5/10 ,  H01F1/0054

摘要： Magnetic iron oxide nanoparticles (MIONs) having silica (SiMION) and gold-silica (AuSiMION) nanoshells, methods of their preparation, and their use in cancer imaging and therapy applications are disclosed.

摘要翻译： 公开了具有二氧化硅（SiMION）和金 - 二氧化硅（AuSiMION）纳米壳的磁性氧化铁纳米颗粒（MION），其制备方法及其在癌症成像和治疗应用中的应用。

公开(公告)号：US09417302B2

公开(公告)日：2016-08-16

申请号：US13202435

申请日：2010-02-22

申请人： Michael Harald Kuhn

发明人： Michael Harald Kuhn

IPC分类号： A61H1/00 ,  G01R33/48 ,  A61B5/05 ,  A61N1/40 ,  A61N2/02 ,  A61N7/02 ,  A61B5/01 ,  A61B5/055 ,  A61B17/225 ,  A61B18/18 ,  A61B17/00 ,  A61B18/00 ,  A61B19/00 ,  A61N5/02 ,  A61B5/00

CPC分类号： G01R33/4804 ,  A61B5/01 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/7207 ,  A61B5/7267 ,  A61B17/2251 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00084 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00791 ,  A61B2090/374 ,  A61N1/406 ,  A61N2/02 ,  A61N5/02 ,  A61N7/02 ,  G01R33/4808 ,  G01R33/4814

摘要： A therapeutic apparatus for treating a subject comprising: a first heating means adapted for heating a first region of the subject, a first control means for controlling the power directed into the first region by the first heating means such that the power stays below a threshold value, a particle heating means adapted for heating magnetic nanoparticles within a second region of the subject using a time varying magnetic field, wherein the first region comprises the second region.

摘要翻译： 一种用于治疗受试者的治疗装置，包括：第一加热装置，适于加热受试者的第一区域;第一控制装置，用于通过第一加热装置控制引导到第一区域的功率，使得功率保持在阈值以下 ，适于使用时变磁场加热所述受试者的第二区域内的磁性纳米颗粒的颗粒加热装置，其中所述第一区域包括所述第二区域。