公开(公告)号：US06576466B2

公开(公告)日：2003-06-10

申请号：US08513865

申请日：1995-12-04

申请人： Herbert Jungfer ,  Heinrich Barchet ,  Winfred Albert ,  Ulrich Weidle

发明人： Herbert Jungfer ,  Heinrich Barchet ,  Winfred Albert ,  Ulrich Weidle

IPC分类号： C12N506

CPC分类号： A61K39/0011 ,  A61K2039/5158

摘要： The present invention concerns a mammalian cell line which when co-cultured with lymphocytes during which allogenic stimulation is avoided activates lymphocytes fo form tumoricidal cells, a process for the production of tumoricidal T lymphocytes by co-culturing lymphocytes with this cell line, the tumoricidal T lymphocytes obtained by means of this process and the use of the cells according to the present invention for the production of a therapeutic agent which can be used in tumour therapy.

摘要翻译： 本发明涉及哺乳动物细胞系，当与避免同种异体刺激的淋巴细胞共同培养时，可激活形成杀肿瘤细胞的淋巴细胞，通过与该细胞系共培养淋巴细胞产生杀肿瘤T淋巴细胞的方法，杀肿瘤T 通过该方法获得的淋巴细胞和根据本发明的细胞用于生产可用于肿瘤治疗的治疗剂。