公开(公告)号：US20130029931A1

公开(公告)日：2013-01-31

申请号：US13557864

申请日：2012-07-25

申请人： Tianfeng Chen ,  Ka Hing Wong ,  Hua-Lian Wu ,  Wenjie Zheng ,  Man Kin Wong ,  Wing Yin Cornelia Man

发明人： Tianfeng Chen ,  Ka Hing Wong ,  Hua-Lian Wu ,  Wenjie Zheng ,  Man Kin Wong ,  Wing Yin Cornelia Man

IPC分类号： A61K31/715 ,  A61P35/00

CPC分类号： A61K9/10 ,  A61K9/0095 ,  A61K9/14 ,  A61K31/375 ,  A61K31/715 ,  A61K33/04 ,  A61K2300/00

摘要： The preparation of Pleurotus tuber-regium polysaccharide functionalized nano-selenium hydrosol with anti-tumor activity includes the following steps: 1) at normal temperature and under normal pressure, adding a Vitamin C solution to an aqueous solution of Pleurotus tuber-regium polysaccharides, and mixing uniformly; 2) adding dropwise a selenium dioxide solution or a selenite solution to the solution while mixing uniformly; and 3) adding water to the solution to a pre-determined volume, to obtain a Pleurotus tuber-regium polysaccharide functionalized nano-selenium hydrosol when the red color of the product is no longer deepened. The polysaccharides are used to control the particle size of nano-selenium, to obtain functionalized nano-elemental selenium with high anti-tumor activity and low toxicity. The anti-tumor activity of the biologically active molecule polysaccharides and the physiological effect of nano-selenium are combined, and a synergistic anti-tumor effect is achieved.

摘要翻译： 具有抗肿瘤活性的侧耳菇多糖功能化纳米硒水溶胶的制备方法如下：1）在常温常压下，将维生素C溶液加入到侧耳菇多糖水溶液中， 均匀混合 2）在均匀混合的同时向溶液中滴加二氧化硒溶液或亚硒酸盐溶液; 和3）当溶液中的红色不再加深时，向溶液中加入预定体积的水，以获得侧耳菇多糖官能化的纳米硒水溶胶。 多糖用于控制纳米硒的粒径，获得具有高抗肿瘤活性和低毒性的功能化纳米元素硒。 结合生物活性分子多糖的抗肿瘤活性和纳米硒的生理作用，达到协同抗肿瘤效果。

公开(公告)号：US09072669B2

公开(公告)日：2015-07-07

申请号：US13557864

申请日：2012-07-25

申请人： Tianfeng Chen ,  Ka Hing Wong ,  Hua-Lian Wu ,  Wenjie Zheng ,  Man Kin Wong ,  Wing Yin Cornelia Man

发明人： Tianfeng Chen ,  Ka Hing Wong ,  Hua-Lian Wu ,  Wenjie Zheng ,  Man Kin Wong ,  Wing Yin Cornelia Man

IPC分类号： A61K33/04 ,  A61K31/715 ,  A61K9/10 ,  A61K31/375 ,  A61K9/14 ,  A61K9/00

CPC分类号： A61K9/10 ,  A61K9/0095 ,  A61K9/14 ,  A61K31/375 ,  A61K31/715 ,  A61K33/04 ,  A61K2300/00

摘要： The preparation of Pleurotus tuber-regium polysaccharide functionalized nano-selenium hydrosol with anti-tumor activity includes the following steps: 1) at normal temperature and under normal pressure, adding a Vitamin C solution to an aqueous solution of Pleurotus tuber-regium polysaccharides, and mixing uniformly; 2) adding dropwise a selenium dioxide solution or a selenite solution to the solution while mixing uniformly; and 3) adding water to the solution to a pre-determined volume, to obtain a Pleurotus tuber-regium polysaccharide functionalized nano-selenium hydrosol when the red color of the product is no longer deepened. The polysaccharides are used to control the particle size of nano-selenium, to obtain functionalized nano-elemental selenium with high anti-tumor activity and low toxicity. The anti-tumor activity of the biologically active molecule polysaccharides and the physiological effect of nano-selenium are combined, and a synergistic anti-tumor effect is achieved.

摘要翻译： 具有抗肿瘤活性的侧耳菇多糖功能化纳米硒水溶胶的制备方法如下：1）在常温常压下，将维生素C溶液加入到侧耳菇多糖水溶液中， 均匀混合 2）在均匀混合的同时向溶液中滴加二氧化硒溶液或亚硒酸盐溶液; 和3）当溶液中的红色不再加深时，向溶液中加入预定体积的水，以获得侧耳菇多糖官能化的纳米硒水溶胶。 多糖用于控制纳米硒的粒径，获得具有高抗肿瘤活性和低毒性的功能化纳米元素硒。 结合生物活性分子多糖的抗肿瘤活性和纳米硒的生理作用，达到协同抗肿瘤效果。