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    Compositions of and new uses for N-acylanilinobutyric acids
    2.
    发明授权
    Compositions of and new uses for N-acylanilinobutyric acids 失效
    N-酰基酰氨基丁酸的组合物和新用途

    公开(公告)号：US4034111A

    公开(公告)日：1977-07-05

    申请号：US571501

    申请日：1975-04-25

    申请人： Wolfgang Schoetensack ,  Richard Riedel

    发明人： Wolfgang Schoetensack ,  Richard Riedel

    IPC分类号： A61K31/195

    CPC分类号： A61K31/195

    摘要： Pharmaceutically-acceptable compositions containing, as an active ingredient, at least one N-acylanilinobutyric acid have uses unrelated to the choleretic activity suggested in U.S. Pat. No. 3,780,095. Moreover, the further uses generally involve administration of smaller doses than would be required to obtain a choleretic effect.The new uses include: a) increasing the gastrointestinal enzyme secretion and b) tonicizing the cardiovascular system. The increase of the gastrointestinal enzyme secretion is applied in the treatment of different diseases such as treatment of sprue, treatment of indigestion, treatment of acute and chronic pancreatitis, therapy for degenerated intestine mucous membrane, treatment of stomach spasms, treatment of stomach ulcers, treatment of diseases where the application of an antigastrin is indicated. The tonicizing of the cardiovascular system is applied in, e.g., increasing the circulation of blood in internal organs, increasing the heart force, reating disturbances in the liver function.

    摘要翻译： 含有作为活性成分的至少一种N-酰基酰氨基丁酸的药学上可接受的组合物具有与美国专利No。 3,780,095。 此外，进一步的用途通常包括施用比获得胆汁效果所需要的更小的剂量。

    Therapeutic piperazinylalkyl-quinazolone-(4)-derivatives
    3.
    发明授权
    Therapeutic piperazinylalkyl-quinazolone-(4)-derivatives 失效
    治疗性哌嗪基烷基 - 喹唑酮酮（4）衍生物

    公开(公告)号：US3984555A

    公开(公告)日：1976-10-05

    申请号：US148100

    申请日：1971-05-28

    申请人： Hermann Amschler ,  Wolfgang Schoetensack ,  Kurt Klemm

    发明人： Hermann Amschler ,  Wolfgang Schoetensack ,  Kurt Klemm

    IPC分类号： C07D403/06 ,  A61K31/505

    CPC分类号： C07D403/06

    摘要： Aryl-substituted piperazinylalkyl-quniazolone-(4) derivatives suitable forse as hypotensive, antihistaminic, and analgesic drugs are described. Process for the preparation of the compounds by (1) intra molecular condensation of the product obtained from the reaction of a halogen carboxylanilide with an aryl piperazine; (2) reaction of an .omega.-halogen-alkyl quinazolone with an aryl piperazine; or (3), reaction of an anthranilic acid with a (4-aryl-piperazinyl-(1) carboxylamide, nitride, amidine, or iminoester, followed by alkylation of the product are also described. Pharmaceutical compositions containing the compounds and halogenalkanoic acid-6-carbamyl anilides useful for preparing the compounds are disclosed.

    摘要翻译： 描述适合用作降压药，抗组胺药和镇痛药的芳基取代的哌嗪基烷基 - 重氮酮 - （4）衍生物。 通过（1）由卤代羧酰苯胺与芳基哌嗪的反应获得的产物的分子内缩合制备化合物的方法; （2）ω-卤素 - 烷基喹唑酮与芳基哌嗪的反应; 或（3），还描述了邻氨基苯甲酸与（4-芳基 - 哌嗪基 - （1）羧酰胺，氮化物，脒或亚氨基酯的反应，随后产物的烷基化反应，含有化合物和卤代烷酸 - 公开了可用于制备化合物的6-氨基甲酰苯胺。

    Compositions of and new uses for N-acylanilinobutyric acids
    4.
    发明授权
    Compositions of and new uses for N-acylanilinobutyric acids 失效
    N-酰基酰氨基丁酸的组合物和新用途

    公开(公告)号：US4205088A

    公开(公告)日：1980-05-27

    申请号：US785959

    申请日：1977-04-08

    申请人： Wolfgang Schoetensack ,  Richard Riedel

    发明人： Wolfgang Schoetensack ,  Richard Riedel

    IPC分类号： A61K31/195

    CPC分类号： A61K31/195

    摘要： Pharmaceutically-acceptable compositions containing, as an active ingredient, at least one N-acylanilinobutyric acid have uses unrelated to the choleretic activity suggested in U.S. Pat. No. 3,780,095. Moreover, the further uses generally involve administration of smaller doses than would be required to obtain a choleretic effect.The new uses include: (a) increasing the gastrointestinal enzyme secretion and (b) tonicizing the cardiovascular system. The increase of the gastrointestinal enzyme secretion is applied in the treatment of different diseases, such as treatment of sprue, treatment of indigestion, treatment of acute and chronic pancreatitis, therapy for degenerated intestine mucous membrane, treatment of stomach spasms, treatment of stomach ulcers, treatment of diseases where the application of an antigastrin is indicated. The tonicising of the cardiovascular system is applied in, e.g., increasing the circulation of blood in internal organs, increasing the heart force, treating disturbances in the liver function.

    摘要翻译： 含有作为活性成分的至少一种N-酰基酰氨基丁酸的药学上可接受的组合物具有与美国专利No。 3,780,095。 此外，进一步的用途通常包括施用比获得胆汁效果所需要的更小的剂量。 新用途包括：（a）增加胃肠酶分泌和（b）增强心血管系统。 胃肠酶分泌的增加用于治疗不同的疾病，如注射治疗，消化不良治疗，治疗急性和慢性胰腺炎，治疗退行性肠粘膜，治疗胃痉挛，治疗胃溃疡， 治疗应用抗胃酸素的疾病。 心血管系统的滋养应用于例如增加内脏中血液的循环，增加心脏力，治疗肝功能紊乱。