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公开(公告)号：USRE50050E1
公开(公告)日：2024-07-23
申请号：US17699114
申请日：2022-03-19
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Robert Anderson , Danielle Aubele , Marc Evanchik , Jonathan Charles Fox , Brian Kane , Puping Lu , Robert McDowell , Hector Rodriguez , Yonghong Song , Arvinder Sran
IPC分类号： A61K31/513 , A61K45/06 , C07D239/545 , C07D239/553 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
CPC分类号： A61K31/513 , A61K45/06 , C07D239/545 , C07D239/553 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.
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公开(公告)号：US20180311242A1
公开(公告)日：2018-11-01
申请号：US15897549
申请日：2018-02-15
申请人： MYOKARDIA, Inc.
发明人： JOHAN OSLOB , Robert Anderson , Danielle Aubele , Marc Evanchik , Jonathan Charles Fox , Brian Kane , Puping Lu , Robert McDowell , Hector Rodriguez , Yonghong Song , Arvinder Sran
IPC分类号： A61K31/513 , A61K45/06 , C07D413/12 , C07D401/12 , C07D403/04 , C07D239/545 , C07D401/04 , C07D413/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D239/553
CPC分类号： A61K31/513 , A61K45/06 , C07D239/545 , C07D239/553 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.
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公开(公告)号：US20170313855A1
公开(公告)日：2017-11-02
申请号：US15526158
申请日：2015-11-20
发明人： Adam Cox , Nicolas Proust , Jason J. Hanthorn , Li Nie
IPC分类号： C08K5/3462 , C08K5/098 , C08K3/34 , F16L9/12 , C07D239/545
CPC分类号： C08K5/3462 , C07D239/545 , C08K3/34 , C08K5/098 , F16L9/12 , C08L27/24
摘要： The disclosed technology relates to a novel coupled 6-amino uracil derivative, and the use of the coupled 6-amino uracil derivative as a stabilizer in halogen containing polymer compounds. In particular, the disclosed technology relates to the use of a coupled 6-amino uracil derivative as a stabilizer in vinyl chloride compounds, such as, for example, chlorinated polyvinyl chloride (CPVC) compounds.
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公开(公告)号：US20170036969A1
公开(公告)日：2017-02-09
申请号：US15304129
申请日：2015-04-16
申请人： BASF SE
发明人： Barbara NAVE , Joachim DICKHAUT , Mihiret Tekeste SISAY , Alexander WISSEMEIER , Wolfram ZERULLA , Johan EBENHOECH , Wolfgang WEIGELT
IPC分类号： C05G3/08 , C07C255/54 , C07C333/08 , C07C217/84 , C07D249/14 , C07D513/04 , C07C43/215 , C07C271/58 , C07D241/24 , C07C233/25 , C07D241/18 , C07C251/48 , C07D257/04 , C07D249/12 , C07C275/34 , C07C205/37 , C07D233/86 , C07D401/12 , C07D213/73 , C07C255/65 , C07C243/22 , C07C69/92 , C07C243/28 , C07C251/76 , C07C49/255 , C07C47/575 , C07D277/68 , C07C43/23 , C07D253/075 , C07C335/18 , C07D307/68 , C07D495/04 , C07C311/37 , C07D239/34 , C07D209/34 , C07D295/205 , C07D231/56 , C07D277/54 , C07D211/16 , C07D275/04 , C07D487/04 , C07D239/545 , C07D401/04 , C07D239/42 , C07D275/03 , C07D261/20 , C07D311/22 , C07D491/048 , C07D271/10 , C07D261/12 , C07D295/192 , C09K15/30 , C09K15/28 , C09K15/20 , C09K15/06 , C09K15/22 , C09K15/12 , C05C3/00 , C07C271/44
CPC分类号： C05G3/08 , C05C3/00 , C07C43/215 , C07C43/23 , C07C47/575 , C07C49/255 , C07C69/92 , C07C205/37 , C07C217/84 , C07C233/25 , C07C243/22 , C07C243/28 , C07C251/48 , C07C251/76 , C07C255/54 , C07C255/65 , C07C271/44 , C07C271/58 , C07C275/34 , C07C311/37 , C07C333/08 , C07C335/18 , C07D209/34 , C07D211/16 , C07D213/73 , C07D231/56 , C07D233/86 , C07D239/34 , C07D239/42 , C07D239/545 , C07D241/18 , C07D241/24 , C07D249/12 , C07D249/14 , C07D253/075 , C07D257/04 , C07D261/12 , C07D261/20 , C07D271/10 , C07D275/03 , C07D275/04 , C07D277/54 , C07D277/68 , C07D295/192 , C07D295/205 , C07D307/68 , C07D311/22 , C07D401/04 , C07D401/12 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04 , C09K15/06 , C09K15/08 , C09K15/12 , C09K15/20 , C09K15/22 , C09K15/28 , C09K15/30 , Y02E50/343 , Y02P60/218 , Y02W30/47
摘要： The present invention relates to novel nitrification inhibitors of formula I. Moreover, the invention relates to the use of these novel nitrification inhibitors for reducing nitrification, as well as agrochemical mixtures and compositions comprising the nitrification inhibitors. Further encompassed by the present invention are methods for reducing nitrification comprising the treatment of plants, soil and/or loci with said nitrification inhibitors, and methods for treating a fertilizer or a composition by applying said nitrification inhibitor.
摘要翻译： 本发明涉及式I的新型硝化抑制剂。此外，本发明涉及这些新型硝化抑制剂用于还原硝化作用的用途，以及包含硝化抑制剂的农药混合物和组合物。 本发明还包括减少硝化的方法，包括用所述硝化抑制剂处理植物，土壤和/或基因座，以及通过施用所述硝化抑制剂处理肥料或组合物的方法。
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公开(公告)号：US09550763B2
公开(公告)日：2017-01-24
申请号：US14377331
申请日：2013-02-08
申请人： Shionogi & Co., Ltd.
IPC分类号： A61K31/506 , C07D417/14 , C07D405/14 , C07D401/12 , C07D405/12 , C07D239/54 , C07D417/12 , C07D239/545 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14
CPC分类号： C07D417/14 , A61K31/506 , C07D239/47 , C07D239/48 , C07D239/54 , C07D239/545 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect, e.g. a compound of Formula (I): wherein R2 is a hydrogen atom or the like; ring A is five- to seven-cycloalkane or the like; C is a carbon atom; Q1 and Q2 are carbon atoms or the like; R9a and R9b are carbon atoms or the like; R6 is cycloalkyl or the like; R7 is a group represented by the formula: wherein ring D is benzene or the like; carbon atom a and b are carbon atoms; ring B is an aromatic carbocyclic ring or the like; s and s′ are 0 or the like; R9 and R9′ are halogen or the like, or the like, or its pharmaceutically acceptable salt.
摘要翻译： 本发明提供具有P2X3和/或P2X2 / 3受体拮抗作用的新化合物，例如 式（I）的化合物：其中R2是氢原子等; 环A为五至七环烷烃等; C是碳原子; Q1和Q2是碳原子等; R9a和R9b是碳原子等; R6是环烷基等; R7为下式所示的基团：其中环D为苯等; 碳原子a和b是碳原子; 环B是芳族碳环等; s和s'为0等; R9和R9'是卤素等，或其药学上可接受的盐。
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公开(公告)号：US20160221965A1
公开(公告)日：2016-08-04
申请号：US15021372
申请日：2014-09-12
发明人： Alexander STRAUB , Marie-Pierre COLLIN , Michael KOCH , Jutta MEYER , Karl-Heinz SCHLEMMER , Carl Friedrich NISING , Nicole BIBER , Sonja ANLAUF , Matthias Beat WITTWER
IPC分类号： C07D239/47 , A61K45/06 , C07D401/12 , C07D239/56 , C07D239/36 , C07D401/06 , A61K31/513 , C07D239/52
CPC分类号： C07D239/47 , A61K31/513 , A61K45/06 , C07D239/36 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/56 , C07D401/06 , C07D401/12
摘要： The present application relates to novel 2,5-disubstituted 6-(trifluoromethyl)pyrimidin-4(3H)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.
摘要翻译： 本申请涉及新的2,5-二取代的6-（三氟甲基）嘧啶-4（3H） - 酮衍生物，其制备方法单独使用或组合用于治疗和/或预防疾病，以及 用于制备用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管，肾，炎症和纤维化疾病。
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公开(公告)号：US09321736B2
公开(公告)日：2016-04-26
申请号：US14535719
申请日：2014-11-07
发明人： Robin Clark , George Hynd , Nicholas Ray , Mohammad Sajad
IPC分类号： C07D239/02 , C07D239/54 , C07D213/55 , C07D213/74 , C07D239/26 , C07D239/553 , C07D239/56 , C07D277/30 , C07D401/06 , C07D417/06 , C07D239/22 , C07D403/06 , C07D413/06 , C07F7/18 , C07D239/545 , C07D417/08
CPC分类号： C07D239/54 , C07D213/55 , C07D213/74 , C07D239/22 , C07D239/26 , C07D239/545 , C07D239/553 , C07D239/56 , C07D277/30 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D417/08 , C07F7/1804
摘要： The present invention provides a class of pyrimidinedione cyclohexyl compounds and methods of using these compounds as glucocorticoid receptor modulators.
摘要翻译： 本发明提供了一类嘧啶二酮环己基化合物和使用这些化合物作为糖皮质激素受体调节剂的方法。
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公开(公告)号：US20160024072A1
公开(公告)日：2016-01-28
申请号：US14377331
申请日：2013-02-08
申请人： Shionogi & Co., Ltd.
IPC分类号： C07D417/14 , C07D239/545 , C07D417/12 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D401/14 , C07D401/12 , C07D405/12
CPC分类号： C07D417/14 , A61K31/506 , C07D239/47 , C07D239/48 , C07D239/54 , C07D239/545 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect, e.g. a compound of Formula (I): wherein R2 is a hydrogen atom or the like; ring A is five- to seven-cycloalkane or the like; C is a carbon atom; Q1 and Q2 are carbon atoms or the like; R9a and R9b are carbon atoms or the like; R6 is cycloalkyl or the like; R7 is a group represented by the formula: wherein ring D is benzene or the like; carbon atom a and b are carbon atoms; ring B is an aromatic carbocyclic ring or the like; s and s′ are 0 or the like; R9 and R9′ are halogen or the like, or the like, or its pharmaceutically acceptable salt.
摘要翻译： 本发明提供具有P2X3和/或P2X2 / 3受体拮抗作用的新化合物，例如 式（I）的化合物：其中R2是氢原子等; 环A为五至七环烷烃等; C是碳原子; Q1和Q2是碳原子等; R9a和R9b是碳原子等; R6是环烷基等; R7为下式所示的基团：其中环D为苯等; 碳原子a和b是碳原子; 环B是芳族碳环等; s和s'为0等; R9和R9'是卤素等，或其药学上可接受的盐。
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9.发明授权Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds 有权合成1,3-取代氨基尿嘧啶和其他黄嘌呤相关化合物的方法公开(公告)号：US09221821B2
公开(公告)日：2015-12-29
申请号：US13907239
申请日：2013-05-31
发明人： Nhut Diep , Yuriy B. Kalyan
IPC分类号： C07D473/06 , C07D239/22 , C07D401/12 , C07D239/545
CPC分类号： C07D473/06 , C07D239/22 , C07D239/545 , C07D401/12
摘要： Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.
摘要翻译： 提供了合成二取代的氨基尿嘧啶和黄嘌呤和/或黄嘌呤相关化合物的方法。
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公开(公告)号：US20150183812A1
公开(公告)日：2015-07-02
申请号：US14454404
申请日：2014-08-07
申请人： Japan Tobacco Inc.
发明人： Hisashi KAWASAKI , Hiroyuki ABE , Kazuhide HAYAKAWA , Tetsuya IIDA , Shinichi KIKUCHI , Takayuki YAMAGUCHI , Toyomichi NANAYAMA , Hironori KURACHI , Masahiro TAMARU , Yoshikazu HORI , Mitsuru TAKAHASHI , Takayuki YOSHIDA , Toshiyuki SAKAI
IPC分类号： C07F9/53 , C07C275/50 , C07D487/04 , C07D471/04 , C07D471/16 , C07C275/30 , C07D239/545
CPC分类号： C07D471/04 , A61K31/519 , C07C275/30 , C07C275/50 , C07C2601/16 , C07D239/545 , C07D239/553 , C07D239/62 , C07D471/16 , C07D487/04 , C07F9/53
摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要翻译： 本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。 本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。 此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。
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