公开(公告)号：US20100310583A1

公开(公告)日：2010-12-09

申请号：US12525020

申请日：2008-01-31

申请人： Judy Lieberman ,  Erwei Song ,  Fengyan Yu ,  Xiaoqu Hu

发明人： Judy Lieberman ,  Erwei Song ,  Fengyan Yu ,  Xiaoqu Hu

IPC分类号： A61K31/713 ,  A61K31/7088 ,  A61K38/16 ,  A61K39/395 ,  A61K38/22 ,  A61P35/00

CPC分类号： A61K31/7105 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/6807 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/141

摘要： The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. In some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells.

摘要翻译： 本发明涉及治疗或预防受试者癌症的方法，特别是本发明涉及治疗和/或预防癌症的方法，其包括通过施用降低表达或缺乏癌症干细胞的miRNA来靶向癌症干细胞 细胞。 在一些实施方案中，减少或缺乏癌干细胞的miRNA是let-7 miRNA。 在替代实施方案中，本发明涉及治疗和/或预防癌症的方法，包括通过施用在癌症干细胞中具有增加的表达水平的miRNA来靶向癌症干细胞。 本发明的另一方面涉及富集癌症干细胞群体的方法。 本发明的另一方面涉及鉴定有助于癌症干细胞的自我更新能力的miRNA的方法。