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    LET-7 MICRORNA AND MIMETICS THEREOF AS THERAPEUTICS FOR CANCER
    1.
    发明申请
    LET-7 MICRORNA AND MIMETICS THEREOF AS THERAPEUTICS FOR CANCER 审中-公开
    LET-7 MICRORNA及其作为癌症治疗的MIME类型

    公开(公告)号：US20100310583A1

    公开(公告)日：2010-12-09

    申请号：US12525020

    申请日：2008-01-31

    申请人： Judy Lieberman ,  Erwei Song ,  Fengyan Yu ,  Xiaoqu Hu

    发明人： Judy Lieberman ,  Erwei Song ,  Fengyan Yu ,  Xiaoqu Hu

    IPC分类号： A61K31/713 ,  A61K31/7088 ,  A61K38/16 ,  A61K39/395 ,  A61K38/22 ,  A61P35/00

    CPC分类号： A61K31/7105 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/6807 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/141

    摘要： The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. In some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells.

    摘要翻译： 本发明涉及治疗或预防受试者癌症的方法，特别是本发明涉及治疗和/或预防癌症的方法，其包括通过施用降低表达或缺乏癌症干细胞的miRNA来靶向癌症干细胞 细胞。 在一些实施方案中，减少或缺乏癌干细胞的miRNA是let-7 miRNA。 在替代实施方案中，本发明涉及治疗和/或预防癌症的方法，包括通过施用在癌症干细胞中具有增加的表达水平的miRNA来靶向癌症干细胞。 本发明的另一方面涉及富集癌症干细胞群体的方法。 本发明的另一方面涉及鉴定有助于癌症干细胞的自我更新能力的miRNA的方法。

    METHOD OF DELIVERING RNA INTERFERENCE AND USES THEREOF
    2.
    发明申请
    METHOD OF DELIVERING RNA INTERFERENCE AND USES THEREOF 审中-公开
    提供RNA干扰的方法及其用途

    公开(公告)号：US20120258534A1

    公开(公告)日：2012-10-11

    申请号：US13433592

    申请日：2012-03-29

    申请人： Judy Lieberman ,  Erwei Song

    发明人： Judy Lieberman ,  Erwei Song

    IPC分类号： C12N5/02

    CPC分类号： C12N15/1138 ,  C07K14/46 ,  C07K16/1063 ,  C07K2317/77 ,  C07K2319/74 ,  C07K2319/85 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1132 ,  C12N15/1135 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2310/3513 ,  C12N2320/32

    摘要： The invention provides a method of RNA interference, which comprises contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a fusion protein, the fusion protein comprising (1) a targeting moiety, which will specifically binds to a site on a target cell, and (2) a binding moiety, which will bind to the double stranded RNA, wherein the double stranded RNA segment initiates RNA interference in the cell.

    摘要翻译： 本发明提供了RNA干扰的方法，其包括使细胞与融合蛋白双链RNA复合物接触，所述复合物包含含有目标双链RNA的双链RNA区段和融合蛋白，所述融合蛋白包含（1 ）靶向部分，其将特异性结合靶细胞上的位点，和（2）将结合双链RNA的结合部分，其中双链RNA区段启动细胞中的RNA干扰。

    Inhibition of gene expression using RNA interfering agents
    3.
    发明授权
    Inhibition of gene expression using RNA interfering agents 有权
    使用RNA干扰剂抑制基因表达

    公开(公告)号：US07696179B2

    公开(公告)日：2010-04-13

    申请号：US10533621

    申请日：2003-10-29

    申请人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwei Song ,  Sang-Kyung Lee ,  Premlata Shankar

    发明人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwei Song ,  Sang-Kyung Lee ,  Premlata Shankar

    IPC分类号： A01N63/00 ,  A61K48/00

    CPC分类号： C12N15/1138 ,  A61K38/00 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/1617 ,  A61M1/3406 ,  A61M1/3609 ,  A61M1/3612 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/33 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/50 ,  A61M2205/52 ,  C12N15/1132 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  Y02A50/465

    摘要： The present invention is based, at least in part, on the discovery of compositions and methods for the treatment and prevention of infectious diseases or disorders, e.g., HIV infection, AIDS, and AIDS-related diseases. In particular, the present invention pertains to methods of modulating cellular gene expression or protein activity, e.g., CCR5, gene expression or protein activity and/or gene expression or protein activity of a gene or sequence of an infectious agent, in order to treat or prevent infectious diseases or disorders, HIV infection, AIDS, or an AIDS-related disease or disorder. In one embodiment the combination of an RNA interfering agent targeting a cellular gene in combination with an RNA interfering agent targeting a gene or sequence of an infectious agent results in prolonged prevention of infection by an infectious agent. The present invention is based on the identification of novel RNA interference agents, e.g., siRNA molecules, which target cellular genes, e.g., chemokine receptors, e.g., the CCR5 gene, and result in inhibition of target gene expression on target gene expressing cells, thereby inhibiting entry of infectious agents, e,g., HIV infection into target cells, prevention infection, and/or suppressing replication in established infection.

    摘要翻译： 本发明至少部分地基于发现用于治疗和预防感染性疾病或病症的组合物和方法，例如HIV感染，AIDS和AIDS相关疾病。 特别地，本发明涉及调节细胞基因表达或蛋白质活性的方法，例如CCR5，基因表达或蛋白质活性和/或感染因子的基因或序列的基因表达或蛋白质活性，以便治疗或 预防传染病或疾病，艾滋病毒感染，艾滋病或艾滋病相关疾病或病症。 在一个实施方案中，靶向细胞基因的RNA干扰剂与靶向感染因子的基因或序列的RNA干扰剂的组合导致长期预防感染性感染的感染。 本发明基于鉴定靶向细胞基因（例如趋化因子受体，例如CCR5基因）的新型RNA干扰剂，例如siRNA分子，并导致靶基因表达细胞的靶基因表达的抑制，从而 抑制感染因子的侵入，例如艾滋病毒感染进入靶细胞，预防感染和/或抑制确定的感染中的复制。

    Methods for Treating and Preventing Apoptosis-Related Diseases Using Rna Interfering Agents
    5.
    发明申请
    Methods for Treating and Preventing Apoptosis-Related Diseases Using Rna Interfering Agents 审中-公开
    使用Rna干扰剂治疗和预防凋亡相关疾病的方法

    公开(公告)号：US20070254850A1

    公开(公告)日：2007-11-01

    申请号：US10533622

    申请日：2003-10-30

    申请人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwei Song ,  Sang-Kyung Lee ,  Nedim Ince ,  Premlata Shankar

    发明人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwei Song ,  Sang-Kyung Lee ,  Nedim Ince ,  Premlata Shankar

    IPC分类号： A61K48/00 ,  C12N15/867 ,  C12N5/08

    CPC分类号： C12N15/1136 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2799/027

    摘要： The present invention is based, at least in part, on the discovery of compositions and methods useful in the modulation, e.g., inhibition, of gene expression or protein activity. In particular, the present invention is based on novel RNA interfering agents, e.g., siRNA molecules which target apoptosis-related genes or proinflammatory cytokines, and result in reduction, e.g., prolonged reduction, of apoptosis-related gene expression or proinflammatory cytokine expression in cells. Inhibition of apoptosis-related gene expression or protein activity or proinflammatory cytokine expression or protein activity, e.g., by the siRNAs of the invention, inhibits apoptosis-mediated diseases or disorders and proinflammatory cytokine mediated diseases or disorders, including, for example, transplant rejection, hepatitis, liver injury, sepsis, and cancer.

    摘要翻译： 本发明至少部分地基于发现可用于调节，例如抑制基因表达或蛋白质活性的组合物和方法。 特别地，本发明基于新的RNA干扰剂，例如靶向凋亡相关基因或促炎细胞因子的siRNA分子，并导致细胞凋亡相关基因表达或促炎细胞因子表达的减少，例如延长的减少 。 抑制凋亡相关基因表达或蛋白质活性或促炎细胞因子表达或蛋白质活性，例如通过本发明的siRNA抑制细胞凋亡介导的疾病或病症和促炎细胞因子介导的疾病或病症，包括例如移植排斥反应， 肝炎，肝损伤，败血症和癌症。

    Method for Treating and Preventing Ischemia-Reperfusion Injury Using Rna Interfering Agent
    6.
    发明申请
    Method for Treating and Preventing Ischemia-Reperfusion Injury Using Rna Interfering Agent 审中-公开
    使用Rna干扰剂治疗和预防缺血再灌注损伤的方法

    公开(公告)号：US20080227733A1

    公开(公告)日：2008-09-18

    申请号：US10577814

    申请日：2004-11-01

    申请人： Judy Lieberman ,  Peter Hamar ,  Erwei Song

    发明人： Judy Lieberman ,  Peter Hamar ,  Erwei Song

    IPC分类号： A61K31/7052 ,  C12N15/00 ,  A01N1/02 ,  A61P9/10 ,  C12N15/87

    CPC分类号： C12N15/1138 ,  C12N2310/14

    摘要： The present invention is based, at least in part, on the discovery of methods useful in the modulation, e.g., inhibition, of gene expression or protein activity, e.g., apoptosis-related gene expression, e.g., Fas gene expression or cytokine expression, e.g., proinflammatory cytokine expression. In particular, the present invention is based on novel RNA interfering agents, e.g., siRNA in reduction, e.g., prolonged reduction, of apoptosis-related gene expression or cytokine expression in cells. Inhibition of apoptosis-related gene expression or protein activity or cytokine gene expression or protein activity, e.g. by the siRNAs used in the methods of the invention, inhibits ischemia-reperfusion injury.

    摘要翻译： 本发明至少部分地基于发现可用于调节，例如抑制基因表达或蛋白质活性的方法，例如凋亡相关基因表达，例如Fas基因表达或细胞因子表达，例如 ，促炎细胞因子表达。 特别地，本发明基于新的RNA干扰剂，例如siRNA在细胞中的还原，例如延长的减少凋亡相关基因表达或细胞因子表达。 抑制凋亡相关基因表达或蛋白质活性或细胞因子基因表达或蛋白质活性，例如 通过本发明方法中使用的siRNA抑制缺血再灌注损伤。

    siRNA microbicides for preventing and treating diseases
    10.
    发明授权
    siRNA microbicides for preventing and treating diseases 有权
    用于预防和治疗疾病的siRNA杀微生物剂

    公开(公告)号：US07943589B2

    公开(公告)日：2011-05-17

    申请号：US11916334

    申请日：2006-06-05

    申请人： Judy Lieberman ,  Deborah Palliser ,  David Knipe

    发明人： Judy Lieberman ,  Deborah Palliser ,  David Knipe

    IPC分类号： A61K31/70 ,  C07H21/04 ,  C07H21/02 ,  C12Q1/68

    CPC分类号： C12N15/1133 ,  A61K48/00 ,  C12N15/1131 ,  C12N2310/14

    摘要： The invention provides a microbicidal composition comprising at least one siRNA. The siRNA is an RNA duplex made of one or two molecules. A portion of the siRNA is identical to a target sequence in an essential gene of a virus. The virus may be a herpesvirus, for example, HSV-1 or HSV-2. Preferably, the herpesvirus is HSV-2. The microbicidal composition further comprises a pharmaceutically acceptable carrier. Also included in the invention are methods to prevent and treat viral infections by administration of the microbicidal composition. Preferably, the microbicidal composition is administered transmucosally.

    摘要翻译： 本发明提供包含至少一种siRNA的杀微生物组合物。 siRNA是由一个或两个分子制成的RNA双链体。 siRNA的一部分与病毒的必需基因中的靶序列相同。 病毒可以是疱疹病毒，例如HSV-1或HSV-2。 优选地，疱疹病毒是HSV-2。 杀微生物组合物还包含药学上可接受的载体。 本发明还包括通过施用杀微生物剂组合物预防和治疗病毒感染的方法。 优选地，所述杀微生物组合物经粘膜给药。