公开(公告)号：US20100234604A1

公开(公告)日：2010-09-16

申请号：US12722711

申请日：2010-03-12

申请人： Xin Linghu ,  Kathleen Linn ,  Kevin M. Maloney ,  Mark McLaughlin ,  Gang Qian

发明人： Xin Linghu ,  Kathleen Linn ,  Kevin M. Maloney ,  Mark McLaughlin ,  Gang Qian

IPC分类号： C07D211/20 ,  C07D213/62

CPC分类号： C07D213/79 ,  C07D211/24

摘要： The present invention relates to novel substituted aryl sulfone intermediates and processes for preparing the same. An aspect of this invention relates to a process for making substituted aryl sulfone intermediates utilizing a one-pot deacylation-carbon/sulfur bond formation step. The invention also relates to a process for preparing intermediates that are used to make the compounds of formula I. Some of the advantages of the present invention include manufacturing flexibility and efficiency, high yield synthesis using a one pot deacylation and carbon-sulfur bond formation step of a thioester intermediate and the like. This and other aspects of the invention will be realized upon review of the specification as a whole.

公开(公告)号：US20100234603A1

公开(公告)日：2010-09-16

申请号：US12722779

申请日：2010-03-12

申请人： Xin Linghu ,  Kathleen Linn ,  Kevin M. Maloney ,  Mark McLaughlin ,  Gang Qian

发明人： Xin Linghu ,  Kathleen Linn ,  Kevin M. Maloney ,  Mark McLaughlin ,  Gang Qian

IPC分类号： C07D211/14

CPC分类号： C07D401/04 ,  C07D211/24 ,  C07D213/79

摘要： The present invention relates to novel substituted aryl sulfone intermediates and processes for preparing the same. An aspect of this invention relates to a process for making substituted aryl sulfone intermediates utilizing a one-pot deacylation-carbon/sulfur bond formation step. The invention also relates to a process for preparing intermediates that are used to make the compounds of formula I. Some of the advantages of the present invention include manufacturing flexibility and efficiency, high yield synthesis using a one pot deacylation and carbon-sulfur bond formation step of a thioester intermediate and the like. This and other aspects of the invention will be realized upon review of the specification as a whole.

摘要翻译： 本发明涉及新型取代的芳基砜中间体及其制备方法。 本发明的一个方面涉及利用一锅脱酰基 - 碳/硫键形成步骤制备取代的芳基砜中间体的方法。 本发明还涉及用于制备式I化合物的中间体的方法。本发明的一些优点包括使用一锅脱酰和碳 - 硫键形成步骤制备柔性和效率，高产率合成 的硫酯中间体等。 本发明的这个和其它方面将在整个规范审查之后实现。