公开(公告)号：US20050262537A1

公开(公告)日：2005-11-24

申请号：US11141693

申请日：2005-05-31

Applicant: Paul Baran ,  Xu Lin ,  John Pickens ,  Michael Field

Inventor： Paul Baran ,  Xu Lin ,  John Pickens ,  Michael Field

IPC: H04L29/06 ,  H04N7/173 ,  H05K1/02 ,  H05K1/14 ,  H05K1/18

CPC classification number: H04L63/068 ,  H04L29/06027 ,  H04L63/10 ,  H04L65/4084 ,  H04N7/17318 ,  H04N21/2318 ,  H04N21/2326 ,  H04N21/23406 ,  H04N21/2347 ,  H04N21/2362 ,  H04N21/2365 ,  H04N21/26606 ,  H04N21/4347 ,  H04N21/47202 ,  H04N21/6405 ,  H04N21/6587 ,  H05K1/0275 ,  H05K1/144 ,  H05K1/185 ,  H05K2201/10151

Abstract: A packet timing method and apparatus for use with a system for controlling digital TV program start time. An encoder inserts a program clock reference (PCR) timing field, in at least two intervals in transport packets. A decoder generates a decoder-clock signal from the PCR timing signal, which has the same frequency as an encoder-clock signal used for encoding. In response to the PCR timing field, a rate of consumption of data is synchronized with a rate of production of data, and chroma sub-carrier is synchronized.

Abstract translation: 一种用于控制数字电视节目开始时间的系统的分组定时方法和装置。 编码器在传输分组中以至少两个间隔插入程序时钟参考（PCR）定时字段。 解码器从PCR定时信号产生解码器时钟信号，该定时信号具有与用于编码的编码器 - 时钟信号相同的频率。 响应于PCR定时字段，数据的消耗速率与数据的生成速率同步，并且色度子载波被同步。

公开(公告)号：US20050108763A1

公开(公告)日：2005-05-19

申请号：US10976351

申请日：2004-10-28

Applicant: Paul Baran ,  Xu Lin ,  John Pickens ,  Michael Field

Inventor： Paul Baran ,  Xu Lin ,  John Pickens ,  Michael Field

IPC: H04L29/06 ,  H04N7/173 ,  H05K1/02 ,  H05K1/14 ,  H05K1/18 ,  H04H9/00 ,  H04N7/16

CPC classification number: H04L63/068 ,  H04L29/06027 ,  H04L63/10 ,  H04L65/4084 ,  H04N7/17318 ,  H04N21/2318 ,  H04N21/2326 ,  H04N21/23406 ,  H04N21/2347 ,  H04N21/2362 ,  H04N21/2365 ,  H04N21/26606 ,  H04N21/4347 ,  H04N21/47202 ,  H04N21/6405 ,  H04N21/6587 ,  H05K1/0275 ,  H05K1/144 ,  H05K1/185 ,  H05K2201/10151

Abstract: A video system for providing a large number of video streams. The video system includes a video server and dividing means. Storage means, a switch and control means are located at the video server. The video server has a plurality of central-processing units (CPUs). The dividing means divides a plurality of input video-streams entering the video system, and sends the divided plurality of input-video streams, with each divided video stream identified with a separate Ethernet address, to the video server. The storage means stores an input video-stream of the plurality of input video-streams as a stored-video stream. The switch routes an input-video stream of the plurality of input-video streams to the storage means. The control means controls the storage means to replay the stored-video stream and to control portions of the stored-video stream at an appropriate time, and controls the plurality of CPUs at the video server to work in parallel.

Abstract translation: 用于提供大量视频流的视频系统。 视频系统包括视频服务器和分割装置。 存储装置，开关和控制装置位于视频服务器处。 视频服务器具有多个中央处理单元（CPU）。 分割装置分割进入视频系统的多个输入视频流，并将划分的多个输入视频流与每个分离的视频流以单独的以太网地址标识，发送给视频服务器。 存储装置将多个输入视频流的输入视频流存储为存储视频流。 交换机将多个输入视频流的输入视频流路由到存储装置。 控制装置控制存储装置重放所存储的视频流并在适当的时间控制存储视频流的部分，并且控制视频服务器上的多个CPU并行工作。

公开(公告)号：US20050043244A1

公开(公告)日：2005-02-24

申请号：US10950890

申请日：2004-09-27

Applicant: Xu Lin ,  Terrence Doyle ,  Ivan King

Inventor： Xu Lin ,  Terrence Doyle ,  Ivan King

IPC: A61K38/04 ,  A61K38/16 ,  C07C311/55 ,  C07F9/12 ,  A61K31/175 ,  A61K31/195 ,  A61K31/277 ,  A61K38/05 ,  A61K38/06 ,  A61K38/08 ,  A61K38/10

CPC classification number: C07C311/55 ,  A61K38/04 ,  A61K38/16 ,  C07F9/12

Abstract: The present invention relates to compounds according to the structure (I): Where R is —CH3 or —CH2CH2Cl; R′ is C1-C7 alkyl or —CH2CH2Cl; R2 or R4 is OP03H2, N02, OCO(Glu-OH), NHCO(Glu-OH), NHR7 and unassigned groups of R2, R3, R4, R5 and R6 are, independently, H, F, Cl, Br, I, OH, OP03H2, OCH3, CF3, OCF3, NO2, CN, SO2CH3, SO2CF3, COCH3, COOCH3, SCH3, SFs, NH2, NHR7, N(CH3)2, OPO3H2, or a C1-C7 alkyl group with the proviso that when any two of unassigned groups of R2, R3, R4, R5 or R6 are other than H, the other two of unassigned groups of R2, R3, R4, R5 or R6 are H. R7 is H or polyglutamyl as described. Phosphoric acid and glutamic acid can be a free acid or pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及根据结构（I）的化合物：其中R是-CH 3或-CH 2 CH 2 Cl; R'是C 1 -C 7烷基或-CH 2 CH 2 Cl; R2或R4是OP03H2，N02，OCO（Glu-OH），NHCO（Glu-OH），NHR7，R2，R3，R4，R5和R6的未分配基团独立地是H，F，Cl，Br， OH，OPO 3 H 2，OCH 3，CF 3，OCF 3，NO 2，CN，SO 2 CH 3，SO 2 CF 3，COCH 3，COOCH 3，SCH 3，SF，NH 2，NHR 7，N（CH 3）2，OPO 3 H 2或C 1 -C 7烷基， R2，R3，R4，R5或R6的任何两个未分配的基团不是H，R2，R3，R4，R5或R6的另外两个未分配的基团是H.R 7是H或所述的聚谷氨酰基。 磷酸和谷氨酸可以是游离酸或其药学上可接受的盐。

公开(公告)号：US20080299556A2

公开(公告)日：2008-12-04

申请号：US11856909

申请日：2007-09-18

Applicant: Ivan King ,  Xu Lin

Inventor： Ivan King ,  Xu Lin

IPC: C12Q1/68 ,  C07D473/30 ,  G01N33/53 ,  C07D473/34

CPC classification number: C12Q1/48 ,  G01N2333/91245

Abstract: This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring the signal, thereby determining the AGT activity in said sample. This invention provides different uses of this method.

Abstract translation: 本发明提供了一种测定样品中烷基泛酰基转移酶活性的方法，包括以下步骤：将样品置于适当的条件下，使得AGT具有功能; 在允许AGT和AGTD结合产生信号的条件下将样品与AGT检测器接触; 并测量信号，从而确定所述样品中的AGT活性。 本发明提供了该方法的不同用途。

公开(公告)号：US20050198679A1

公开(公告)日：2005-09-08

申请号：US11098786

申请日：2005-04-04

Applicant: Paul Baran ,  Xu Lin ,  John Pickens ,  Michael Field

Inventor： Paul Baran ,  Xu Lin ,  John Pickens ,  Michael Field

IPC: H04L29/06 ,  H04N7/173 ,  H05K1/02 ,  H05K1/14 ,  H05K1/18 ,  G06F3/00 ,  G06F13/00 ,  H04N5/445 ,  H04N7/16 ,  H04N7/20

CPC classification number: H04L63/068 ,  H04L29/06027 ,  H04L63/10 ,  H04L65/4084 ,  H04N7/17318 ,  H04N21/2318 ,  H04N21/2326 ,  H04N21/23406 ,  H04N21/2347 ,  H04N21/2362 ,  H04N21/2365 ,  H04N21/26606 ,  H04N21/4347 ,  H04N21/47202 ,  H04N21/6405 ,  H04N21/6587 ,  H05K1/0275 ,  H05K1/144 ,  H05K1/185 ,  H05K2201/10151

Abstract: A method of an input unit of a method and apparatus for controlling digital TV program start time. The input unit and method of the input unit receive digital channels from multiple sources, as a plurality of digital-transport streams, respectively. Each digital-transport stream has a multiplicity of transport packets. The input unit and method time-stamp each of the received transport packets of the multiplicity of transport packets, thereby generating a plurality of time-stamped packets, and aggregate the plurality of time-stamped packets, and scramble the aggregated plurality of time-stamped packets. The scrambled-aggregated plurality of time-stamped packets are encapsulated.

Abstract translation: 一种用于控制数字电视节目开始时间的方法和装置的输入单元的方法。 输入单元的输入单元和方法分别从多个源接收数字信道作为多个数字传输流。 每个数字传输流具有多个传输分组。 输入单元和方法对多个传输分组的所接收的传输分组中的每一个进行时间标记，从而生成多个时间戳分组，并且聚合多个时间戳分组，并且将聚合的多个时间戳 数据包 被加密的多个时间戳的分组被封装。

公开(公告)号：US20090075945A1

公开(公告)日：2009-03-19

申请号：US12080357

申请日：2008-04-02

Applicant: Xu Lin ,  Ivan King ,  Michael F. Belcourt ,  Terrence W. Doyle

Inventor： Xu Lin ,  Ivan King ,  Michael F. Belcourt ,  Terrence W. Doyle

IPC: A61K31/662 ,  A61P35/00

CPC classification number: C07F9/12 ,  C07F9/6518

Abstract: Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Methods of treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy. where R is C1-C10 alkyl or haloalkyl; R′ and R″ are each independently C1-C10 alkyl; and R1 is C1-C10 alkyl, or a pharmaceutically acceptable salt, solvate, polymorph or metabolite thereof.

Abstract translation: 磺酰肼的新型含磷前体药物具有以下公式。 要求治疗癌症的方法。 前述药物包括对映异构体，立体异构体和互变异构体，以及来自所有阶段的药学上可接受的盐或溶剂合物和代谢物。 上述前药优先在缺氧性肿瘤中活化，并且可以单独给予，也可以与其它抗癌剂或光疗法或放疗相结合。 其中R是C 1 -C 10烷基或卤代烷基; R'和R“各自独立地为C 1 -C 10烷基; 并且R 1是C 1 -C 10烷基，或其药学上可接受的盐，溶剂合物，多晶型物或代谢物。

公开(公告)号：US07405317B2

公开(公告)日：2008-07-29

申请号：US11232252

申请日：2005-09-21

Applicant: Xu Lin ,  Ivan King ,  Michael F. Belcourt ,  Terrence W. Doyle

Inventor： Xu Lin ,  Ivan King ,  Michael F. Belcourt ,  Terrence W. Doyle

IPC: C07F9/22 ,  C07C313/04 ,  C07C313/06

CPC classification number: C07F9/12 ,  C07F9/6518

Abstract: Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Pharmaceutical compositions and uses thereof in the treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy. where R is C1-C10 alkyl or haloalkyl; R′ and R″ are each independently C1-C10 alkyl; R1 is CH3; and X is O; or a pharmaceutically acceptable salt, solvate, polymorph or metabolite thereof.

Abstract translation: 磺酰肼的新型含磷前体药物具有以下公式。 要求保护药物组合物及其在治疗癌症中的用途。 前述药物包括对映异构体，立体异构体和互变异构体，以及来自所有阶段的药学上可接受的盐或溶剂合物和代谢物。 上述前药优先在缺氧性肿瘤中活化，并且可以单独给予，也可以与其它抗癌剂或光疗法或放疗相结合。 其中R是C 1 -C 10烷基或卤代烷基; R'和R“各自独立地为C 1 -C 10烷基; R 1是CH 3 3; X为O; 或其药学上可接受的盐，溶剂化物，多晶型物或代谢物。

公开(公告)号：US20050198680A1

公开(公告)日：2005-09-08

申请号：US11098787

申请日：2005-04-05

Applicant: Paul Baran ,  Xu Lin ,  John Pickens ,  Michael Field

Inventor： Paul Baran ,  Xu Lin ,  John Pickens ,  Michael Field

IPC: H04L29/06 ,  H04N7/173 ,  H05K1/02 ,  H05K1/14 ,  H05K1/18 ,  H04N7/20

CPC classification number: H04L63/068 ,  H04L29/06027 ,  H04L63/10 ,  H04L65/4084 ,  H04N7/17318 ,  H04N21/2318 ,  H04N21/2326 ,  H04N21/23406 ,  H04N21/2347 ,  H04N21/2362 ,  H04N21/2365 ,  H04N21/26606 ,  H04N21/4347 ,  H04N21/47202 ,  H04N21/6405 ,  H04N21/6587 ,  H05K1/0275 ,  H05K1/144 ,  H05K1/185 ,  H05K2201/10151

Abstract: A conditional access method and apparatus for use with a system for controlling of digital TV program start time. Subscriber access is authorized to digital program streams. Content are divided into a plurality of working periods. Each working period of the plurality of working periods is scrambled with a different working key. A working key of a given period is delivered ahead of the given period. The working key is synchronized with scrambling control bits in an header working keys are inserted into an entitlement control message (ECM) packet, and the ECM packet is encrypted using a service key. A time period is inserted into the ECM packet during which the service key is valid. A service key is inserted in an entitlement.

Abstract translation: 一种用于控制数字电视节目开始时间的系统的条件访问方法和装置。 用户接入被授权给数字节目流。 内容分为多个工作时段。 多个工作周期的每个工作周期用不同的工作密钥加扰。 给定期间的工作密钥在给定期限之前交付。 工作密钥与报头中的加扰控制位同步工作密钥插入到授权控制消息（ECM）分组中，并且使用服务密钥对ECM分组进行加密。 一个时间段被插入ECM包中，其中服务密钥是有效的。 一个服务密钥插入一个权利。

公开(公告)号：US20050039212A1

公开(公告)日：2005-02-17

申请号：US10911736

申请日：2004-08-04

Applicant: Paul Baran ,  Xu Lin ,  John Pickens ,  Michael Field

Inventor： Paul Baran ,  Xu Lin ,  John Pickens ,  Michael Field

IPC: H04L29/06 ,  H04N7/173 ,  H05K1/02 ,  H05K1/14 ,  H05K1/18 ,  H04N7/18

CPC classification number: H04L63/068 ,  H04L29/06027 ,  H04L63/10 ,  H04L65/4084 ,  H04N7/17318 ,  H04N21/2318 ,  H04N21/2326 ,  H04N21/23406 ,  H04N21/2347 ,  H04N21/2362 ,  H04N21/2365 ,  H04N21/26606 ,  H04N21/4347 ,  H04N21/47202 ,  H04N21/6405 ,  H04N21/6587 ,  H05K1/0275 ,  H05K1/144 ,  H05K1/185 ,  H05K2201/10151

Abstract: A construction arrangement for a small set-top box to protect cryptographic capabilities and prevent a digital program in clear from being able to be tapped as required by Digital Rights Management protocols. A first layer of sheet metal capable of blocking X-rays, is formed as a shallow pan to hold a set of printed circuit boards. A second layer has a thin epoxy based printed circuit material. A third layer has a printed circuit board with integrated components placed on top of the second layer. A fourth layer has a three layer thin printed circuit board with a first and second metallic layer and holes for large components, such as electrolytic capacitors. A black liquid thermosetting epoxy fills the interstices between the sheet metal layer and the second layer, and between the second layer and the third layer, and between the third layer and the fourth layer, thereby preventing access to exposed circuit trace carrying digital signals in the clear. A connection from the first metallic layer of the fourth printed circuit material layer to a sending circuit and a connection from the second metallic layer so that a short between these two layers sets off an indicator circuit that an attempt is made to enter the protected area.

Abstract translation: 一种小型机顶盒的构造安排，用于保护加密功能，并防止数字程序清楚地被数字版权管理协议所要求的。 能够阻挡X射线的第一层金属片被形成为浅盘以保持一组印刷电路板。 第二层具有薄的环氧基印刷电路材料。 第三层具有布置在第二层顶部的集成元件的印刷电路板。 第四层具有三层薄印刷电路板，其具有第一和第二金属层以及诸如电解电容器的大部件的孔。 黑色液体热固性环氧树脂填充金属片层与第二层之间的间隙，以及第二层与第三层之间以及第三层与第四层之间的间隙，从而防止在载体中承载数字信号的裸露电路迹线 明确。 从第四印刷电路材料层的第一金属层到发送电路的连接以及来自第二金属层的连接，使得这两层之间的短路使得指示电路成为尝试进入保护区域的指示电路。

公开(公告)号：US08026395B1

公开(公告)日：2011-09-27

申请号：US12454997

申请日：2009-05-27

Applicant: Xu Lin ,  Ivan King

Inventor： Xu Lin ,  Ivan King

IPC: C07C303/00

CPC classification number: C07C303/40 ,  C07C311/55

Abstract: The present invention relates to simple, safe, high-yield methods of synthesizing VNP40101M, 1,2-bis(methylsulfonyl)-2-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine, an anti-neoplasia agent. One particularly preferred method uses methyl chloroformamide in a one-pot reaction at elevated temperatures to provide VNP40101M in high yield.

Abstract translation: 本发明涉及合成VNP40101M，1,2-双（甲基磺酰基）-2-（2-氯乙基）-2-（甲基氨基羰基）肼，抗肿瘤剂的简单，安全，高产出的方法。 一种特别优选的方法是在高温下使用甲基氯仿酰胺进行一锅反应，以高产率提供VNP40101M。