公开(公告)号：US08669046B2

公开(公告)日：2014-03-11

申请号：US12920838

申请日：2009-03-10

申请人： Xuguang (Sean) Li ,  Runtao He ,  Gary Van Domselaar

发明人： Xuguang (Sean) Li ,  Runtao He ,  Gary Van Domselaar

IPC分类号： C07K16/10 ,  G01N33/569 ,  C07K7/08 ,  C07K17/06 ,  C12Q1/70 ,  A61K39/145

CPC分类号： C07K16/1018 ,  C07K14/005 ,  C12N2760/16122 ,  G01N2333/11

摘要： Antibodies that specifically bind to a peptide having an amino acid sequence as found at the N-terminus of the HA2 fusion peptide of the influenza A virus may be raised by inoculating a mammal with a conjugate of the peptide. In one embodiment, the conjugate comprises the peptide linked to a spacer (e.g. 6-aminocaproic acid) and a carrier protein (e.g. KLH). The antibodies may be used as a universal reagent for detecting HA proteins of influenza viruses. The antibodies are useful as versatile reagents for laboratory research and vaccine potency determination, especially in the event of pandemic influenza outbreaks.

摘要翻译： 可以通过用肽的缀合物接种哺乳动物来提高特异性结合具有在甲型流感病毒的HA2融合肽的N-末端的氨基酸序列的肽的抗体。 在一个实施方案中，缀合物包含连接到间隔基（例如6-氨基己酸）和载体蛋白（例如KLH）的肽。 抗体可以用作检测流感病毒HA蛋白的通用试剂。 抗体可用作实验室研究和疫苗效力测定的多用试剂，特别是在大流行性流感爆发时。

公开(公告)号：US20110059472A1

公开(公告)日：2011-03-10

申请号：US12920838

申请日：2009-03-10

申请人： Xuguang (Sean) Li ,  Runtao He ,  Gary Van Domselaar

发明人： Xuguang (Sean) Li ,  Runtao He ,  Gary Van Domselaar

IPC分类号： G01N33/53 ,  C07K16/08 ,  C07K7/08

CPC分类号： C07K16/1018 ,  C07K14/005 ,  C12N2760/16122 ,  G01N2333/11

摘要： Antibodies that specifically bind to a peptide having an amino acid sequence as found at the N-terminus of the HA2 fusion peptide of the influenza A virus may be raised by inoculating a mammal with a conjugate of the peptide. In one embodiment, the conjugate comprises the peptide linked to a spacer (e.g. 6-aminocaproic acid) and a carrier protein (e.g. KLH). The antibodies may be used as a universal reagent for detecting HA proteins of influenza viruses. The antibodies are useful as versatile reagents for laboratory research and vaccine potency determination, especially in the event of pandemic influenza outbreaks.

摘要翻译： 可以通过用肽的缀合物接种哺乳动物来提高特异性结合具有在甲型流感病毒的HA2融合肽的N-末端的氨基酸序列的肽的抗体。 在一个实施方案中，缀合物包含连接到间隔基（例如6-氨基己酸）和载体蛋白（例如KLH）的肽。 抗体可以用作检测流感病毒HA蛋白的通用试剂。 抗体可用作实验室研究和疫苗效力测定的多用试剂，特别是在大流行性流感爆发时。