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    SURGICAL SHAPE SENSING FIBER OPTIC APPARATUS AND METHOD THEREOF
    1.
    发明申请
    SURGICAL SHAPE SENSING FIBER OPTIC APPARATUS AND METHOD THEREOF 有权

    公开(公告)号：US20210186648A1

    公开(公告)日：2021-06-24

    申请号：US16754800

    申请日：2018-10-10

    申请人： Yan XIA ,  Lu LAN ,  VIBRONIX, INC.

    发明人： Yan XIA ,  Lu LAN

    IPC分类号： A61B90/00 ,  G06T7/20

    摘要： A shape sensing apparatus for tissue and surgical procedures comprising a processing means and a tunable light source. At least one shape sensing fiber can be used with the shape sensing fiber having a plurality of individual sensing fiber cores having a fiber Bragg grating distributed within the fiber. An optical switch configured to sequentially switch between a multiplex of individual fibers inside the shape sensing fiber for signal detection can be included and a detector can be used to detect the fiber signals. An augmented reality system that receives the tracking data from the shape sensing apparatus, and superimposes visual guidance on its display for precise and intuitive surgical guidance.

    CLAMPING MECHANISM WITH DETACHABLE POSITIONING MEMBER
    6.
    发明申请
    CLAMPING MECHANISM WITH DETACHABLE POSITIONING MEMBER 有权
    具有可拆卸定位构件的夹紧机构

    公开(公告)号：US20120242025A1

    公开(公告)日：2012-09-27

    申请号：US13225678

    申请日：2011-09-06

    申请人： XIAO-BING XU ,  SHAN-YAN XIA ,  ZHI-WEN WANG ,  QING-SONG WEN

    发明人： XIAO-BING XU ,  SHAN-YAN XIA ,  ZHI-WEN WANG ,  QING-SONG WEN

    IPC分类号： B23Q3/06

    CPC分类号： B23Q3/06 ,  B23Q1/25

    摘要： A clamping mechanism includes a positioning member, a support plate, a frame, a fastening assembly, and an operating assembly. The support plate defines a through hole. The fastening assembly is fixed to the frame. The fastening assembly includes a fastening member and an elastic member. The positioning member extends through the through hole of the support plate, and is fastened by the fastening member under an elastic force of the elastic member. The operating assembly resists the fastening member, thereby driving the fastening member away from the positioning member.

    摘要翻译： 夹紧机构包括定位构件，支撑板，框架，紧固组件和操作组件。 支撑板限定了通孔。 紧固组件固定在框架上。 紧固组件包括紧固构件和弹性构件。 定位构件延伸穿过支撑板的通孔，并在弹性构件的弹力下由紧固构件紧固。 操作组件抵抗紧​​固构件，从而驱动紧固构件远离定位构件。

    CLAMPING MECHANISM WITH DETACHABLE POSITION MEMBER
    7.
    发明申请
    CLAMPING MECHANISM WITH DETACHABLE POSITION MEMBER 审中-公开
    具有可拆卸位置构件的夹紧机构

    公开(公告)号：US20120235337A1

    公开(公告)日：2012-09-20

    申请号：US13290006

    申请日：2011-11-04

    申请人： XIAO-BING XU ,  SHAN-YAN XIA ,  ZHI-WEN WANG ,  QING-SONG WEN

    发明人： XIAO-BING XU ,  SHAN-YAN XIA ,  ZHI-WEN WANG ,  QING-SONG WEN

    IPC分类号： B23Q3/06

    CPC分类号： B25B5/08 ,  B25B5/06

    摘要： A clamp mechanism includes a support plate, a frame, a positioning member, a resisting member, an operating assembly. The support plate defines an assembly hole. The frame is fixed to the support plate, and defines a positioning groove and a sliding groove. The positioning member extends through the assembly hole of the support plate, and received in the positioning groove. The operating assembly is connected to the resisting member. The resisting member is movably received in the sliding groove and opposite to the positioning member. The sliding groove has a first end adjacent to the positioning member and a second end away from the positioning member, such that the operating assembly drives the resisting member to move in the sliding groove from the second end to the first end, thereby clamping the positioning member in the positioning groove of the frame.

    摘要翻译： 夹紧机构包括支撑板，框架，定位构件，阻力构件，操作组件。 支撑板限定了组装孔。 框架固定在支撑板上，并且限定了定位槽和滑动槽。 定位构件延伸穿过支撑板的组装孔，并被容纳在定位槽中。 操作组件连接到电阻构件。 抵抗构件可移动地容纳在滑动槽中并与定位构件相对。 滑动槽具有与定位构件相邻的第一端和远离定位构件的第二端，使得操作组件驱动阻力构件在滑动槽中从第二端移动到第一端，从而夹紧定位 构件在框架的定位槽中。

    Bicyclic and tricyclic derivatives as thrombin receptor antagonists
    8.
    发明授权
    Bicyclic and tricyclic derivatives as thrombin receptor antagonists 有权
    双环和三环衍生物作为凝血酶受体拮抗剂

    公开(公告)号：US08153664B2

    公开(公告)日：2012-04-10

    申请号：US11865793

    申请日：2007-10-02

    申请人： Samuel Chackalamannil ,  Mariappan V. Chelliah ,  Yuguang Wang ,  Yan Xia

    发明人： Samuel Chackalamannil ,  Mariappan V. Chelliah ,  Yuguang Wang ,  Yan Xia

    IPC分类号： C07D401/06 ,  A61K31/4439 ,  A61P7/02 ,  A61P7/12 ,  A61P9/10 ,  A61P29/00 ,  A61P19/02 ,  A61P3/10 ,  A61P3/14 ,  A61P11/06 ,  A61P11/08

    CPC分类号： C07D401/06 ,  C07D417/06

    摘要： Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond, the dotted line is optionally a bond or no bond, resulting in a double bond or a single bond, as permitted by the valency requirement and wherein E, A, G M, Het, B, X, R3, R10, R11, R32 and R33 are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.

    摘要翻译： 所述式的杂环取代三环或所述化合物，异构体或外消旋混合物的药学上可接受的盐或溶剂合物，其中代表任选的双键，虚线任选是键或无键，导致双键或单键， 如价格要求所允许的，其中E，A，GM，Het，B，X，R 3，R 10，R 11，R 32和R 33在本文中定义，其余取代基如说明书中所定义，以及药物 含有它们的组合物和通过施用所述化合物治疗与血栓形成，动脉粥样硬化，再狭窄，高血压，心绞痛，心律失常，心力衰竭和癌症相关的疾病的方法。 还要求与其它心血管药物联合治疗。

    Substituted bicyclic and tricyclic thrombin receptor antagonists
    10.
    发明授权
    Substituted bicyclic and tricyclic thrombin receptor antagonists 有权
    取代的双环和三环凝血酶受体拮抗剂

    公开(公告)号：US08022088B2

    公开(公告)日：2011-09-20

    申请号：US11769018

    申请日：2007-06-27

    申请人： Mariappan V. Chelliah ,  Samuel Chackalamannil ,  Yan Xia

    发明人： Mariappan V. Chelliah ,  Samuel Chackalamannil ,  Yan Xia

    IPC分类号： A01N43/40 ,  A61K31/44 ,  C07D405/00

    CPC分类号： C07D405/06

    摘要： Substituted bicyclic and tricyclic modified himbacine derivative of the formula: or a pharmaceutically acceptable salt or solvate of said compound wherein represents an optional double bond and wherein En, Fn, Gn, Zn, Jn, X, R3, R9, R10, R11, R32, R33, B and Het are herein defined are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other agents is also claimed.

    摘要翻译： 其中代表任选的双键的取代的双环和三环修饰的烟草衍生物，或其药学上可接受的盐或溶剂化物，其中En，Fn，Gn，Zn，Jn，X，R3，R9，R10，R11，R32 本文定义的R33，B和Het以及含有它们的药物组合物和通过施用所述化合物治疗与血栓形成，动脉粥样硬化，再狭窄，高血压，心绞痛，心律失常，心力衰竭和癌症相关的疾病的方法。 还声称与其他药剂组合治疗。