公开(公告)号：US08673358B2

公开(公告)日：2014-03-18

申请号：US12805424

申请日：2010-07-30

申请人： Dar-Bin Shieh ,  Chen-Sheng Yeh ,  Dong-Hwang Chen ,  Ya-Na Wu ,  Ping-Ching Wu

发明人： Dar-Bin Shieh ,  Chen-Sheng Yeh ,  Dong-Hwang Chen ,  Ya-Na Wu ,  Ping-Ching Wu

IPC分类号： A61K9/16 ,  A61K9/50

CPC分类号： A61K31/7072 ,  A61K9/1676 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00

摘要： The present invention relates to a nano-carrier for an anticancer drug, which comprises: a metal nanoparticle; and a polynucleotide for connecting with an anticancer drug having a pyrimidine group or a purine group, wherein the polynucleotide connects to a surface of the metal nanoparticle, and the anticancer drug binds to the polynucleotide through the pyrimidine group or the purine group. In addition, the present invention also provides a complex of an anticancer drug and a nano-carrier, a pharmaceutical composition thereof, a method for manufacturing the complex, and a method for treating a cancer by using the pharmaceutical composition.

摘要翻译： 本发明涉及抗癌药物的纳米载体，其包含：金属纳米粒子; 以及与具有嘧啶基或嘌呤基的抗癌药连接的多核苷酸，其中多核苷酸与金属纳米粒子的表面连接，抗癌药通过嘧啶基或嘌呤基与多核苷酸结合。 此外，本发明还提供了抗癌药物和纳米载体的复合物，其药物组合物，复合物的制造方法，以及使用该药物组合物治疗癌症的方法。

公开(公告)号：US20120027861A1

公开(公告)日：2012-02-02

申请号：US12805424

申请日：2010-07-30

申请人： Dar-Bin Shieh ,  Chen-Sheng Yeh ,  Dong-Hwang Chen ,  Ya-Na Wu ,  Ping-Ching Wu

发明人： Dar-Bin Shieh ,  Chen-Sheng Yeh ,  Dong-Hwang Chen ,  Ya-Na Wu ,  Ping-Ching Wu

IPC分类号： A61K9/14 ,  A61K31/7088 ,  A61P35/00 ,  C07H21/04

CPC分类号： A61K31/7072 ,  A61K9/1676 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00

摘要： The present invention relates to a nano-carrier for an anticancer drug, which comprises: a metal nanoparticle; and a polynucleotide for connecting with an anticancer drug having a pyrimidine group or a purine group, wherein the polynucleotide connects to a surface of the metal nanoparticle, and the anticancer drug binds to the polynucleotide through the pyrimidine group or the purine group. In addition, the present invention also provides a complex of an anticancer drug and a nano-carrier, a pharmaceutical composition thereof, a method for manufacturing the complex, and a method for treating a cancer by using the pharmaceutical composition.

摘要翻译： 本发明涉及抗癌药物的纳米载体，其包含：金属纳米粒子; 以及与具有嘧啶基或嘌呤基的抗癌药连接的多核苷酸，其中多核苷酸与金属纳米粒子的表面连接，抗癌药通过嘧啶基或嘌呤基与多核苷酸结合。 此外，本发明还提供了抗癌药物和纳米载体的复合物，其药物组合物，该复合物的制造方法以及使用该药物组合物治疗癌症的方法。