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    Pharmaceutical composition for elevating radio-sensitivity of cancer cells, pharmaceutical composition for detecting cancer cells with radio-sensitivity, and detection method thereof
    1.
    发明授权
    Pharmaceutical composition for elevating radio-sensitivity of cancer cells, pharmaceutical composition for detecting cancer cells with radio-sensitivity, and detection method thereof 有权
    用于提高癌细胞的放射敏感性的药物组合物，用于检测具有放射敏感性的癌细胞的药物组合物及其检测方法

    公开(公告)号：US09121049B2

    公开(公告)日：2015-09-01

    申请号：US13628306

    申请日：2012-09-27

    申请人： Dar-Bin Shieh ,  Hai-Wen Chen ,  Chia-Chun Chen ,  Ping-Ching Wu

    发明人： Dar-Bin Shieh ,  Hai-Wen Chen ,  Chia-Chun Chen ,  Ping-Ching Wu

    IPC分类号： G01N33/574 ,  C12Q1/04

    CPC分类号： C12N13/00 ,  C12Q1/04 ,  G01N33/574 ,  G01N33/57423 ,  G01N2800/52

    摘要： The present invention relates to a pharmaceutical composition for elevating radiation-sensitivity of cancer cells, which comprises: a nanoparticle containing with a first element, which is iron, copper, or the combination thereof; and a pharmaceutically acceptable carrier, wherein the nanoparticle is a metal nanoparticle, an alloy nanoparticle, or a metal nanoparticle with core-shell structure, and the size of the nanoparticle is under a controllable range of 3 nm to 150 nm. In addition, the present invention provides a detection method to detect radiation-sensitivity of the cancer cells through different modalities such as CT or MRI due to its native high CT number and magnetic property. Furthermore, the present invention provides a pharmaceutical composition for elevating radiation-sensitivity of the cancer cells through preferential uptake of the nanoparticle, in order to enhance the radiation-sensitivity of the cancer cells and improve the efficiency of radiation therapy to the cancer cells.

    摘要翻译： 本发明涉及一种用于提高癌细胞的放射敏感性的药物组合物，其包含：含有第一元素的纳米颗粒，其为铁，铜或其组合; 和药学上可接受的载体，其中所述纳米颗粒是金属纳米颗粒，合金纳米颗粒或具有核 - 壳结构的金属纳米颗粒，并且所述纳米颗粒的尺寸在3nm至150nm的可控范围内。 此外，本发明提供了一种检测方法，由于其天然的高CT数和磁特性，通过CT或MRI等不同的方式检测癌细胞的放射敏感性。 此外，本发明提供了一种用于通过优先吸收纳米颗粒提高癌细胞的辐射敏感性的药物组合物，以增强癌细胞的辐射敏感性并提高对癌细胞的放射疗法的效率。