公开(公告)号：US08833306B2

公开(公告)日：2014-09-16

申请号：US12094339

申请日：2006-11-20

申请人： Juana Maria Lugo González ,  Mario Pablo Estrada Garcia ,  Alina Rodriguez Mallon ,  Yamila Carpio González ,  Antonio Morales Rojas ,  Osmany Rodrigo González De Sosa ,  Reynold Morales Fernández ,  Fidel Francisco Herrera Miyares

发明人： Juana Maria Lugo González ,  Mario Pablo Estrada Garcia ,  Alina Rodriguez Mallon ,  Yamila Carpio González ,  Antonio Morales Rojas ,  Osmany Rodrigo González De Sosa ,  Reynold Morales Fernández ,  Fidel Francisco Herrera Miyares

IPC分类号： A61K38/18 ,  A01K61/00 ,  A01K61/02

CPC分类号： A61K38/17 ,  A01K61/80 ,  A23K20/147 ,  A23K50/80 ,  C07K14/57563 ,  Y02A40/845

摘要： The present invention is related to the use of variants of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) to stimulate the growth and to improve the immunological system of aquatic organisms. The variants of the peptide were provided by immersion, injection or as a food additive.

摘要翻译： 本发明涉及使用垂体腺苷酸环化酶活化多肽（PACAP）的变体来刺激生长并改善水生生物的免疫系统。 通过浸渍，注射或作为食品添加剂提供肽的变体。

公开(公告)号：US09085634B2

公开(公告)日：2015-07-21

申请号：US13825892

申请日：2011-09-26

申请人： Alina Rodriguez Mallon ,  Erlinda Fernández Díaz ,  Mario Pablo Estrada Garcia ,  Yamila Carpio González

发明人： Alina Rodriguez Mallon ,  Erlinda Fernández Díaz ,  Mario Pablo Estrada Garcia ,  Yamila Carpio González

IPC分类号： A61K39/00 ,  A61K39/002 ,  A61K39/385 ,  C07K14/435

CPC分类号： C07K14/43509 ,  A61K39/0003 ,  C07K14/43527

摘要： The present invention relates to the use of a peptide of P0 ribosomal protein in the manufacture of a vaccine composition to control of ectoparasite infestations and therefore the transmission of their associated pathogens. This peptide is located between 267 and 301 amino acids of the P0 protein, and can be obtained by recombinant means or by chemical synthesis. This peptide can be fused to a carrier protein or peptide, or an immuno-carrier and be included in an oily formulation. The formulations comprising the peptide vaccine confer protection against ticks and ectoparasites known as “sea lice” without generating autoimmunity in the host organism. Among these ticks may be mentioned species as Rhipicephalus microplus, Rhipicephalus sanguineus and Ixodes scapularis, and between sea lice are those of the Caligus and Lepeophtheirus genera.

摘要翻译： 本发明涉及P0核糖体蛋白的肽在制造疫苗组合物中用于控制外寄生虫感染和因此传播其相关病原体的用途。 该肽位于P0蛋白的267和301个氨基酸之间，可以通过重组方法或通过化学合成获得。 该肽可以与载体蛋白或肽或免疫载体融合并包含在油性制剂中。 包含肽疫苗的制剂赋予对称为“海虱”的蜱和外寄生物的保护，而不在宿主生物体中产生自身免疫。 在这些蜱中，可以列举物种如红R属（Rhipicephalus microplus），R，属（Rhipicephalus sanguineus）和sc and属（Ixodes scopularis），海虱属Caligus和Lepeophtheirus属。

公开(公告)号：US20130273095A1

公开(公告)日：2013-10-17

申请号：US13825892

申请日：2011-09-26

申请人： Alina Rodriguez Mallon ,  Erlinda Fernández Díaz ,  Mario Pablo Estrada Garcia ,  Yamila Carpio González

发明人： Alina Rodriguez Mallon ,  Erlinda Fernández Díaz ,  Mario Pablo Estrada Garcia ,  Yamila Carpio González

IPC分类号： C07K14/435 ,  A61K39/00

CPC分类号： C07K14/43509 ,  A61K39/0003 ,  C07K14/43527

摘要： The present invention relates to the use of a peptide of P0 ribosomal protein in the manufacture of a vaccine composition to control of ectoparasite infestations and therefore the transmission of their associated pathogens. This peptide is located between 267 and 301 amino acids of the P0 protein, and can be obtained by recombinant means or by chemical synthesis. This peptide can be fused to a carrier protein or peptide, or an immuno-carrier and be included in an oily formulation. The formulations comprising the peptide vaccine confer protection against ticks and ectoparasites known as “sea lice” without generating autoimmunity in the host organism. Among these ticks may be mentioned species as Rhipicephalus microplus, Rhipicephalus sanguineus and Ixodes scapularis, and between sea lice are those of the Caligus and Lepeophtheirus genera.

摘要翻译： 本发明涉及P0核糖体蛋白的肽在制造疫苗组合物中用于控制外寄生虫感染和因此传播其相关病原体的用途。 该肽位于P0蛋白的267和301个氨基酸之间，可以通过重组方法或通过化学合成获得。 该肽可以与载体蛋白或肽或免疫载体融合并包含在油性制剂中。 包含肽疫苗的制剂赋予对称为“海虱”的蜱和外寄生物的保护，而不在宿主生物体中产生自身免疫。 在这些蜱中，可以列举物种如红R属（Rhipicephalus microplus），R，属（Rhipicephalus sanguineus）和sc and属（Ixodes scopularis），海虱属Caligus和Lepeophtheirus属。