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公开(公告)号:US06387932B1
公开(公告)日:2002-05-14
申请号:US09595142
申请日:2000-06-16
申请人: Changyou Zhou , Alexander Pasternak , Gregori Morriello , Liangqin Guo , Yanping Pan , Lihu Yang , Arthur Patchett
发明人: Changyou Zhou , Alexander Pasternak , Gregori Morriello , Liangqin Guo , Yanping Pan , Lihu Yang , Arthur Patchett
IPC分类号: C07D40106
CPC分类号: C07D401/12 , C07D209/20 , C07D405/14
摘要: This invention relates to non-peptide somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. The compounds provide an improved therapeutic index in the treatment of diabetes, cancer, acromegaly and retenosis. Many of the compounds are orally active.
摘要翻译: 本发明涉及对受体亚型2具有高选择性的非肽生长抑素激动剂化合物。该化合物在治疗糖尿病,癌症,肢端肥大症和视网膜病变方面提供了改进的治疗指标。 许多化合物是口服活性的。