Smart Microscope System for Radiation Biodosimetry

    公开(公告)号:US20210124904A1

    公开(公告)日:2021-04-29

    申请号:US17137317

    申请日:2020-12-29

    摘要: Automation of microscopic pathological diagnosis relies on digital image quality, which, in turn, affects the rates of false positive and negative cellular objects designated as abnormalities. Cytogenetic biodosimetry is a genotoxic assay that detects dicentric chromosomes (DCs) arising from exposure to ionizing radiation. The frequency of DCs is related to radiation dose received, so the inferred radiation dose depends on the accuracy of DC detection. To improve this accuracy, image segmentation methods are used to rank high quality cytogenetic images and eliminate suboptimal metaphase cell data in a sample based on novel quality measures. When sufficient numbers of high quality images are found, the microscope system is directed to terminate metaphase image collection for a sample. The International Atomic Energy Agency recommends at least 500 images be used to estimate radiation dose, however often many more images are collected in order to select the metaphase cells with good morphology for analysis. Improvements in DC recognition increase the accuracy of dose estimates, by reducing false positive (FP) DC detection. A set of chromosome morphology segmentation methods selectively filtered out false DCs, arising primarily from extended prometaphase chromosomes, sister chromatid separation and chromosome fragmentation. This reduced FPs by 55% and was highly specific to the abnormal structures (≥97.7%). Additional procedures were then developed to fully automate image review, resulting in 6 image-level filters that, when combined, selectively remove images with consistently unparsable or incorrectly segmented chromosome morphologies. Overall, these filters can eliminate half of the FPs detected by manual image review. Optimal image selection and FP DCs are minimized by combining multiple feature based segmentation filters and a novel image sorting procedure based on the known distribution of chromosome lengths. Consequently, the average dose estimation error was reduced from 0.4 Gy to

    MOTION COMPENSATED FRAME INTERPOLATION APPARATUS AND METHOD
    2.
    发明申请
    MOTION COMPENSATED FRAME INTERPOLATION APPARATUS AND METHOD 有权
    运动补偿框架插值装置和方法

    公开(公告)号:US20070121725A1

    公开(公告)日:2007-05-31

    申请号:US11557920

    申请日:2006-11-08

    申请人: Yanxin Li

    发明人: Yanxin Li

    IPC分类号: H04N11/02 H04N7/12

    CPC分类号: H04N19/553 H04N7/014

    摘要: We describe a motion compensated frame interpolation apparatus and method that includes a motion vector interpolation module for an object and uncovered area to generate information for motion vectors that cross interpolated pixels in object and/or uncovered areas. A motion vector interpolation module for a covered area generates information for motion vectors that cross interpolated pixels in covered areas. A motion vector counter records a number of motion vectors that cross an interpolated pixel. A buffer for motion vector interpolation buffers the information for motion vectors that cross interpolated pixels in the object and/or uncovered areas and the covered areas. And a video data interpolation module generates video data of the interpolated pixels in object and/or uncovered areas and the covered areas.

    摘要翻译: 我们描述一种运动补偿帧插值装置和方法,其包括用于对象和未覆盖区域的运动矢量插值模块,以生成交叉对象和/或未覆盖区域中的内插像素的运动矢量的信息。 用于覆盖区域的运动矢量插值模块生成与覆盖区域中的内插像素交叉的运动矢量的信息。 运动矢量计数器记录穿过内插像素的多个运动矢量。 用于运动矢量插值的缓冲器缓冲交错对象和/或未覆盖区域和被覆盖区域内插像素的运动矢量的信息。 并且视频数据插值模块生成对象和/或未覆盖区域和覆盖区域中的内插像素的视频数据。

    Smart microscope system for radiation biodosimetry

    公开(公告)号:US10929641B2

    公开(公告)日:2021-02-23

    申请号:US16057710

    申请日:2018-08-07

    摘要: An automated microscope system is described that detects dicentric chromosomes (DCs) in metaphase cells arising from exposure to ionizing radiation. The radiation dose depends on the accuracy of DC detection. Accuracy is increased using image segmentation methods are used to rank high quality cytogenetic images and eliminate suboptimal metaphase cell data in a sample based on novel quality measures. When a sufficient number of high quality images are detected, the microscope system is directed to terminate metaphase image collection for a sample. The microscope system integrates image selection procedures that control an automated digitally controlled microscope with the analysis of acquired metaphase cell images to accurately determine radiation dose. Early termination of image acquisition reduces sample processing time without compromising accuracy. This approach constitutes a reliable and scalable solution that will be essential for analysis of large numbers of potentially exposed individuals.

    Smart Microscope System for Radiation Biodosimetry

    公开(公告)号:US20200050831A1

    公开(公告)日:2020-02-13

    申请号:US16057710

    申请日:2018-08-07

    摘要: An automated microscope system is described that detects dicentric chromosomes (DCs) in metaphase cells arising from exposure to ionizing radiation. The radiation dose depends on the accuracy of DC detection. Accuracy is increased using image segmentation methods are used to rank high quality cytogenetic images and eliminate suboptimal metaphase cell data in a sample based on novel quality measures. When a sufficient number of high quality images are detected, the microscope system is directed to terminate metaphase image collection for a sample. The microscope system integrates image selection procedures that control an automated digitally controlled microscope with the analysis of acquired metaphase cell images to accurately determine radiation dose. Early termination of image acquisition reduces sample processing time without compromising accuracy. This approach constitutes a reliable and scalable solution that will be essential for analysis of large numbers of potentially exposed individuals.

    A FORCED REVERSAL COMBUSTION CHAMBER
    5.
    发明申请
    A FORCED REVERSAL COMBUSTION CHAMBER 审中-公开
    强大的反向燃烧室

    公开(公告)号:US20160265766A1

    公开(公告)日:2016-09-15

    申请号:US14400883

    申请日:2014-04-04

    申请人: Yanxin LI

    发明人: Yanxin LI

    IPC分类号: F23D14/24 F23D11/40 F23C3/00

    摘要: Burners, such as all kinds of fuel oil, gas and powdered coal, have combustion chambers for stabilizing combustion and air distribution. The invention discloses a forced reversal combustion chamber, which has a combustion chamber body, configured as a hollow cavity a plurality of swirl vanes for delivering combustion air into the combustion chamber, correspondingly provided on interior side of flame outlet end of the combustion chamber; in the middle of inner end of the combustion chamber, a fuel nozzle is provided, which inserts into interior wall of the combustion chamber and outlet of which extends through the interior wall of the combustion chamber; outlet end of the combustion chamber after mixing air and fuel is flame outlet. The forced reversal combustion chamber of the invention can provide good flame stabilization, high burn-off rate of fuel and good environmental protection property.

    摘要翻译: 燃烧器,如各种燃料油,煤气和粉煤,具有燃烧室,用于稳定燃烧和空气分配。 本发明公开了一种强制反转燃烧室,其具有燃烧室主体,其构造为中空腔体,多个涡流叶片用于将燃烧空气输送到燃烧室中,相应地设置在燃烧室的火焰出口端的内侧; 在燃烧室的内端的中间,设有燃料喷嘴,其插入燃烧室的内壁并且其出口延伸穿过燃烧室的内壁; 混合空气和燃料后燃烧室的出口端是火焰出口。 本发明的强制反转燃烧室可以提供良好的火焰稳定性,燃料燃烧率高,环保性能好。

    Method and apparatus for motion compensated frame interpolation of covered and uncovered areas
    6.
    发明授权
    Method and apparatus for motion compensated frame interpolation of covered and uncovered areas 有权
    覆盖和未覆盖区域的运动补偿帧插值的方法和装置

    公开(公告)号:US08325811B2

    公开(公告)日:2012-12-04

    申请号:US11557920

    申请日:2006-11-08

    申请人: Yanxin Li

    发明人: Yanxin Li

    IPC分类号: H04N7/12

    CPC分类号: H04N19/553 H04N7/014

    摘要: We describe a motion compensated frame interpolation apparatus and method that includes a motion vector interpolation module for an object and uncovered area to generate information for motion vectors that cross interpolated pixels in object and/or uncovered areas. A motion vector interpolation module for a covered area generates information for motion vectors that cross interpolated pixels in covered areas. A motion vector counter records a number of motion vectors that cross an interpolated pixel. A buffer for motion vector interpolation buffers the information for motion vectors that cross interpolated pixels in the object and/or uncovered areas and the covered areas. And a video data interpolation module generates video data of the interpolated pixels in object and/or uncovered areas and the covered areas.

    摘要翻译: 我们描述一种运动补偿帧插值装置和方法,其包括用于对象和未覆盖区域的运动矢量插值模块,以生成交叉对象和/或未覆盖区域中的内插像素的运动矢量的信息。 用于覆盖区域的运动矢量插值模块生成与覆盖区域中的内插像素交叉的运动矢量的信息。 运动矢量计数器记录穿过内插像素的多个运动矢量。 用于运动矢量插值的缓冲器缓冲交错对象和/或未覆盖区域和被覆盖区域内插像素的运动矢量的信息。 并且视频数据插值模块生成对象和/或未覆盖区域和覆盖区域中的内插像素的视频数据。

    Autocontrol burner and a combustion control method
    7.
    发明授权
    Autocontrol burner and a combustion control method 有权
    自动控制燃烧器和燃烧控制方法

    公开(公告)号:US07306456B2

    公开(公告)日:2007-12-11

    申请号:US10538982

    申请日:2002-12-25

    申请人: Yanxin Li

    发明人: Yanxin Li

    IPC分类号: F23N1/02 F23N5/00

    摘要: A combustion control method for a burner comprises: the fuel supplying means outputs a given amount of fuel oil to the fuel oil atomizing means; the fuel atomizing means sprays fuel atomized gas; said gas is ignited by the igniter; the amount of air is sent to facilitate burning by the air blowing means; the outputting flow rate of fuel oil and the flow rate of air are adjusted automatically, simultaneously and proportionally by controlling the rotating speed of the electric motors of the fuel supplying means and the air blowing means. An autocontrol burner comprises a main body, an oil pump (2), a blower fan (1), a spray gun (9) and an ignition gun (10), and further comprises a programmable control unit (18), motor speed controller (16, 17) and a signal acquisition assembly. The output port of the signal acquisition assembly is connected with the input port of the programmable control unit (18). The oil pump (2) and the blower fan (1) are connected with the programmable control unit (18) by the motor speed controller (16, 17).

    摘要翻译: 燃烧器的燃烧控制方法包括:燃料供给装置向燃料油雾化装置输出给定量的燃料油; 燃料雾化装置喷射燃料雾化气体; 气体被点火器点燃; 空气量被送出以便于通过吹风装置燃烧; 通过控制燃料供给装置和送风装置的电动机的转速,同时且成比例地自动调节燃料油的输出流量和空气的流量。 一种自动控制燃烧器包括主体,油泵(2),鼓风机(1),喷枪(9)和点火枪(10),还包括可编程控制单元(18),马达速度控制器 (16,17)和信号采集组件。 信号采集组件的输出端口与可编程控制单元(18)的输入端口连接。 油泵(2)和鼓风机(1)通过电机速度控制器(16,17)与可编程控制单元(18)连接。

    Smart microscope system for radiation biodosimetry

    公开(公告)号:US11501545B2

    公开(公告)日:2022-11-15

    申请号:US17137317

    申请日:2020-12-29

    摘要: Automation of microscopic pathological diagnosis relies on digital image quality, which, in turn, affects the rates of false positive and negative cellular objects designated as abnormalities. Cytogenetic biodosimetry is a genotoxic assay that detects dicentric chromosomes (DCs) arising from exposure to ionizing radiation. The frequency of DCs is related to radiation dose received, so the inferred radiation dose depends on the accuracy of DC detection. To improve this accuracy, image segmentation methods are used to rank high quality cytogenetic images and eliminate suboptimal metaphase cell data in a sample based on novel quality measures. When sufficient numbers of high quality images are found, the microscope system is directed to terminate metaphase image collection for a sample. The International Atomic Energy Agency recommends at least 500 images be used to estimate radiation dose, however often many more images are collected in order to select the metaphase cells with good morphology for analysis. Improvements in DC recognition increase the accuracy of dose estimates, by reducing false positive (FP) DC detection. A set of chromosome morphology segmentation methods selectively filtered out false DCs, arising primarily from extended prometaphase chromosomes, sister chromatid separation and chromosome fragmentation. This reduced FPs by 55% and was highly specific to the abnormal structures (≥97.7%). Additional procedures were then developed to fully automate image review, resulting in 6 image-level filters that, when combined, selectively remove images with consistently unparsable or incorrectly segmented chromosome morphologies. Overall, these filters can eliminate half of the FPs detected by manual image review. Optimal image selection and FP DCs are minimized by combining multiple feature based segmentation filters and a novel image sorting procedure based on the known distribution of chromosome lengths. Consequently, the average dose estimation error was reduced from 0.4 Gy to

    Autocontrol burner and a combustion control method
    10.
    发明申请
    Autocontrol burner and a combustion control method 有权
    自动控制燃烧器和燃烧控制方法

    公开(公告)号:US20060068347A1

    公开(公告)日:2006-03-30

    申请号:US10538982

    申请日:2002-12-25

    申请人: Yanxin Li

    发明人: Yanxin Li

    IPC分类号: F23N5/00 F23N1/02

    摘要: A combustion control method for a burner comprises: the fuel supplying means outputs a given amount of fuel oil to the fuel oil atomizing means; the fuel atomizing means sprays fuel atomized gas; said gas is ignited by the igniter; the amount of air is sent to facilitate burning by the air blowing means; the outputting flow rate of fuel oil and the flow rate of air are adjusted automatically, simultaneously and proportionally by controlling the rotating speed of the electric motors of the fuel supplying means and the air blowing means. An autocontrol burner comprises a main body, an oil pump (2), a blower fan (1), a spray gun (9) and an ignition gun (10), and further comprises a programmable control unit (18), motor speed controller (16,17) and a signal acquisition assembly. The output port of the signal acquisition assembly is connected with the input port of the programmable control unit (18). The oil pump (2) and the blower fan (1) are connected with the programmable control unit (18) by the motor speed controller (16, 17).

    摘要翻译: 燃烧器的燃烧控制方法包括:燃料供给装置向燃料油雾化装置输出给定量的燃料油; 燃料雾化装置喷射燃料雾化气体; 气体被点火器点燃; 空气量被送出以便于通过吹风装置燃烧; 通过控制燃料供给装置和送风装置的电动机的转速,同时且成比例地自动调节燃料油的输出流量和空气的流量。 一种自动控制燃烧器包括主体,油泵(2),鼓风机(1),喷枪(9)和点火枪(10),还包括可编程控制单元(18),马达速度控制器 (16,17)和信号采集组件。 信号采集组件的输出端口与可编程控制单元(18)的输入端口连接。 油泵(2)和鼓风机(1)通过电机速度控制器(16,17)与可编程控制单元(18)连接。