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公开(公告)号:US4661630A
公开(公告)日:1987-04-28
申请号:US803526
申请日:1985-12-02
IPC分类号: A61K31/19 , A61K31/40 , A61K31/403 , A61K31/4035 , A61P1/04 , A61P3/06 , A61P11/00 , A61P25/08 , A61P25/20 , A61P29/00 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/59 , C07C235/82 , C07D209/48 , C07C103/737
CPC分类号: C07D209/48
摘要: Described herein are novel carboxylic acid amide compounds or carboximide compounds represented by the general formula: ##STR1## wherein Z represents either the monoamido radical of an aromatic or cycloaliphatic ortho dicarboxylic acid or the amide of the corresponding anhydride, and their pharmaceutically acceptable salts; processes for the production thereof; and medicines containing the same. The novel compounds are useful as treating, preventing and improving agents for diseases attended with cerebral dysfunction as well as various symptoms caused by the said diseases.
摘要翻译: 本文描述的是由以下通式表示的新颖的羧酸酰胺化合物或羧甲酰化合物:其中Z表示芳族或脂环族邻二羧酸的单酰氨基或相应酸酐的酰胺及其药学上可接受的盐; 生产过程; 和含有它的药物。 该新化合物可用作治疗,预防和改善患有脑功能障碍的疾病以及由所述疾病引起的各种症状。
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公开(公告)号:US4596826A
公开(公告)日:1986-06-24
申请号:US620050
申请日:1984-06-12
IPC分类号: A61K31/19 , A61K31/40 , A61K31/403 , A61K31/4035 , A61P25/08 , A61P25/20 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/58 , C07C233/59 , C07C233/60 , C07C235/82 , C07D209/48 , C07C101/453 , A61K31/195
CPC分类号: C07D209/48
摘要: Described herein are novel carboxylic acid amide compounds or carboximide compounds represented by the general formula: ##STR1## wherein Z represents a group of the formula (1) or (2): ##STR2## wherein R.sup.1 and R.sup.2 are hydrogen atom or methyl group, respectively; Xs, which may be the same or different, are hydrogen atom, a lower alkyl, lower alkoxy, halo, or alkyl halide group, respectively, and n represents an integer of 0 to 2, and their pharmaceutically acceptable salts; process for the production thereof; and medicines containing the same. The novel compounds are useful as treating, preventing and improving agents for diseases attended with cerebral dysfunction as well as various symptoms caused by the said diseases. Further, the compounds are useful for the improvement of neurosis of the stomach; and treatment and prevention for various constipation.
摘要翻译: 本文描述的是由以下通式表示的新颖的羧酸酰胺化合物或羧甲酰化合物:其中Z代表式(1)或(2)的基团:其中 R1和R2分别是氢原子或甲基; 分别为氢原子,低级烷基,低级烷氧基,卤素或卤代烷基,n表示0〜2的整数,以及它们的药学上可接受的盐,其可以相同或不同。 生产过程; 和含有它的药物。 该新化合物可用作治疗,预防和改善患有脑功能障碍的疾病以及由所述疾病引起的各种症状。 此外,该化合物可用于改善胃的神经症; 治疗和预防各种便秘。
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