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21 条记录 (耗时 0.023 秒)

    Carboxylic acid amide compounds and their derivatives
    1.
    发明授权
    Carboxylic acid amide compounds and their derivatives 失效
    羧酸酰胺化合物及其衍生物

    公开(公告)号：US4596826A

    公开(公告)日：1986-06-24

    申请号：US620050

    申请日：1984-06-12

    申请人： Yasuji Harigaya ,  Hiroo Ogura ,  Mitsuo Mihara ,  Motosuke Yamanaka ,  Kiyomi Yamatsu

    发明人： Yasuji Harigaya ,  Hiroo Ogura ,  Mitsuo Mihara ,  Motosuke Yamanaka ,  Kiyomi Yamatsu

    IPC分类号： A61K31/19 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61P25/08 ,  A61P25/20 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/82 ,  C07D209/48 ,  C07C101/453 ,  A61K31/195

    CPC分类号： C07D209/48

    摘要： Described herein are novel carboxylic acid amide compounds or carboximide compounds represented by the general formula: ##STR1## wherein Z represents a group of the formula (1) or (2): ##STR2## wherein R.sup.1 and R.sup.2 are hydrogen atom or methyl group, respectively; Xs, which may be the same or different, are hydrogen atom, a lower alkyl, lower alkoxy, halo, or alkyl halide group, respectively, and n represents an integer of 0 to 2, and their pharmaceutically acceptable salts; process for the production thereof; and medicines containing the same. The novel compounds are useful as treating, preventing and improving agents for diseases attended with cerebral dysfunction as well as various symptoms caused by the said diseases. Further, the compounds are useful for the improvement of neurosis of the stomach; and treatment and prevention for various constipation.

    摘要翻译： 本文描述的是由以下通式表示的新颖的羧酸酰胺化合物或羧甲酰化合物：其中Z代表式（1）或（2）的基团：其中 R1和R2分别是氢原子或甲基; 分别为氢原子，低级烷基，低级烷氧基，卤素或卤代烷基，n表示0〜2的整数，以及它们的药学上可接受的盐，其可以相同或不同。 生产过程; 和含有它的药物。 该新化合物可用作治疗，预防和改善患有脑功能障碍的疾病以及由所述疾病引起的各种症状。 此外，该化合物可用于改善胃的神经症; 治疗和预防各种便秘。

    Anti-depressant imidazoles
    3.
    发明授权
    Anti-depressant imidazoles 失效
    抗抑郁咪唑

    公开(公告)号：US4533669A

    公开(公告)日：1985-08-06

    申请号：US469548

    申请日：1983-02-25

    申请人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

    发明人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

    IPC分类号： A61K31/415 ,  A61K31/445 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D521/00

    CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/445 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： An anti-depressant imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts. These compounds are useful as agents for treating depression and depressive states.

    摘要翻译： 一种下式的抗抑郁咪唑化合物：其中R1是低级烷基，R2是氢或低级烷基，R3，R4和R5是氢，低级烷基，三氟甲基，氨基，一或二低级烷基氨基， 杂环氨基，卤素或者其中R6是氢，低级烷基或低级烷基磺酰基，A是羰基或磺酰基，R7是低级烷基，卤代低级烷基，一或二低级烷基氨基，单 - 或二 - 低级烷基氨基烷基，未取代的苯基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基，苯基氨基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基氨基）。 及其药学上可接受的酸加成盐。 这些化合物可用作治疗抑郁和抑郁状态的药剂。

    Novel imidazole compound and anti-depressing agent containing the same
    4.
    发明授权
    Novel imidazole compound and anti-depressing agent containing the same 失效
    新型咪唑化合物和含有其的抗抑郁剂

    公开(公告)号：US4301169A

    公开(公告)日：1981-11-17

    申请号：US93469

    申请日：1979-11-13

    申请人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

    发明人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

    IPC分类号： A61K31/415 ,  A61K31/445 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D521/00

    CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/445 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： An imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts.

    摘要翻译： 下式的咪唑化合物：其中R1是低级烷基，R2是氢或低级烷基，R3，R4和R5是氢，低级烷基，三氟甲基，氨基，一或二低级烷基氨基，杂环氨基， 卤素或（其中R6是氢，低级烷基或低级烷基磺酰基，A是羰基或磺酰基，R7是低级烷基，卤代低级烷基，一或二低级烷基氨基，一或二低级烷基氨基烷基， 未取代的苯基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基，苯基氨基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基氨基）; 及其药学上可接受的酸加成盐。

    Anti-depressant imidazoles, compositions and use
    5.
    发明授权
    Anti-depressant imidazoles, compositions and use 失效
    抗抑郁咪唑，组合物和用途

    公开(公告)号：US4602031A

    公开(公告)日：1986-07-22

    申请号：US741935

    申请日：1985-06-06

    申请人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

    发明人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

    IPC分类号： A61K31/415 ,  A61K31/445 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D521/00

    CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/445 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： An antidepressive imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts.

    摘要翻译： 一种下式的抗抑郁咪唑化合物：其中R1是低级烷基，R2是氢或低级烷基，R3，R4和R5是氢，低级烷基，三氟甲基，氨基，一或二低级烷基氨基，杂环氨基 ，卤素或 - - （其中R6是氢，低级烷基或低级烷基磺酰基，A是羰基或磺酰基，R7是低级烷基，卤代低级烷基，一或二低级烷基氨基，一或二 低级烷基，低级烷氧基或三氟甲基，苯基氨基或苯基氨基，具有卤素，低级烷基，低级烷氧基或三氟甲基）; 及其药学上可接受的酸加成盐。

    Acylaminophenyl imidazoles and anti-depressing agent containing the same
    6.
    发明授权
    Acylaminophenyl imidazoles and anti-depressing agent containing the same 失效
    酰氨基苯基咪唑和含有其的抗抑郁剂

    公开(公告)号：US4402966A

    公开(公告)日：1983-09-06

    申请号：US252674

    申请日：1981-04-09

    申请人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

    发明人： Motosuke Yamanaka ,  Isao Saito ,  Kiyomi Yamatsu ,  Takako Fujimoto

    IPC分类号： A61K31/415 ,  A61K31/445 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D521/00

    CPC分类号： C07D233/64 ,  A61K31/415 ,  A61K31/445 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： An imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts.The compounds are useful for treating patients suffering from depression.

    摘要翻译： 下式的咪唑化合物：其中R1是低级烷基，R2是氢或低级烷基，R3，R4和R5是氢，低级烷基，三氟甲基，氨基，一或二低级烷基氨基，杂环氨基， 卤素或（其中R6是氢，低级烷基或低级烷基磺酰基，A是羰基或磺酰基，R7是低级烷基，卤代低级烷基，一或二低级烷基氨基，一或二低级烷基氨基烷基， 未取代的苯基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基，苯基氨基或具有卤素，低级烷基，低级烷氧基或三氟甲基的苯基氨基）; 及其药学上可接受的酸加成盐。 该化合物可用于治疗患有抑郁症的患者。