公开(公告)号：US20130344523A1

公开(公告)日：2013-12-26

申请号：US14000041

申请日：2012-03-29

申请人： Keiichi Kurosaka ,  Munehiro Kubota ,  Kengo Sakaguchi ,  Keita Ino ,  Itsumi Udagawa ,  Kazuki Iwabata ,  Yoichi Takakusagi ,  Yasutaka Seki

发明人： Keiichi Kurosaka ,  Munehiro Kubota ,  Kengo Sakaguchi ,  Keita Ino ,  Itsumi Udagawa ,  Kazuki Iwabata ,  Yoichi Takakusagi ,  Yasutaka Seki

IPC分类号： G01N23/20

CPC分类号： G01N23/20 ,  C07K1/306 ,  C30B7/00 ,  C30B29/54 ,  C30B29/58

摘要： An agent for searching for protein crystallization conditions, containing a water-swellable layered silicate having a fluorine atom and a hydroxyl group, wherein the fluorine atom is covalently bonded to the silicate by isomorphous substitution with the hydroxyl group. A method of searching for protein crystallization conditions, which comprises a step of mixing the agent for searching for protein crystallization conditions described above and a solution in which a protein is dissolved.

摘要翻译： 一种用于搜索蛋白质结晶条件的试剂，其含有具有氟原子和羟基的水溶胀性层状硅酸盐，其中氟原子通过与羟基的同晶取代共价键合到硅酸盐上。 一种搜索蛋白质结晶条件的方法，其包括混合上述蛋白质结晶条件的试剂和溶解有蛋白质的溶液的步骤。

公开(公告)号：US10175183B2

公开(公告)日：2019-01-08

申请号：US14000041

申请日：2012-03-29

申请人： Keiichi Kurosaka ,  Munehiro Kubota ,  Kengo Sakaguchi ,  Keita Ino ,  Itsumi Udagawa ,  Kazuki Iwabata ,  Yoichi Takakusagi ,  Yasutaka Seki

发明人： Keiichi Kurosaka ,  Munehiro Kubota ,  Kengo Sakaguchi ,  Keita Ino ,  Itsumi Udagawa ,  Kazuki Iwabata ,  Yoichi Takakusagi ,  Yasutaka Seki

IPC分类号： G01N23/20 ,  C07K1/30 ,  C30B7/00 ,  C30B29/58 ,  C30B29/54

摘要： An agent for searching for protein crystallization conditions, containing a water-swellable layered silicate having a fluorine atom and a hydroxyl group, wherein the fluorine atom is covalently bonded to the silicate by isomorphous substitution with the hydroxyl group. A method of searching for protein crystallization conditions, which comprises a step of mixing the agent for searching for protein crystallization conditions described above and a solution in which a protein is dissolved.