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1.发明申请公开(公告)号：US20110294696A1
公开(公告)日：2011-12-01
申请号：US13209156
申请日：2011-08-12
申请人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F. Raubertas , Kenny Kin Chung Wong
发明人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F. Raubertas , Kenny Kin Chung Wong
IPC分类号： C40B30/04
CPC分类号： C12Q1/6876 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158
摘要： In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.
摘要翻译： 在一个方面，本发明提供了确定试剂是否更像靶分子的部分激动剂而不是相同靶分子的完全激动剂的方法。 另一方面，本发明提供了选择可降低哺乳动物血浆葡萄糖浓度的候选化合物的方法。 提供了可用于本发明实践的基因群体。
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2.发明授权公开(公告)号：US08014954B2
公开(公告)日：2011-09-06
申请号：US11397327
申请日：2006-04-04
申请人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F Raubertas , Kenny Kin Chung Wong
发明人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F Raubertas , Kenny Kin Chung Wong
CPC分类号： C12Q1/6876 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158
摘要： In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.
摘要翻译： 在一个方面，本发明提供了确定试剂是否更像靶分子的部分激动剂而不是相同靶分子的完全激动剂的方法。 另一方面，本发明提供了选择可降低哺乳动物血浆葡萄糖浓度的候选化合物的方法。 提供了可用于本发明实践的基因群体。
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3.发明申请公开(公告)号：US20060240457A1
公开(公告)日：2006-10-26
申请号：US11397327
申请日：2006-04-04
申请人： Yejun Tan , Hongyue Dai , Pek Lum , John Thompson , Joel Berger , Eric Muise , Richard Raubertas , Kenny Wong
发明人： Yejun Tan , Hongyue Dai , Pek Lum , John Thompson , Joel Berger , Eric Muise , Richard Raubertas , Kenny Wong
CPC分类号： C12Q1/6876 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158
摘要： In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.
摘要翻译： 在一个方面，本发明提供了确定试剂是否更像靶分子的部分激动剂而不是相同靶分子的完全激动剂的方法。 另一方面，本发明提供了选择可降低哺乳动物血浆葡萄糖浓度的候选化合物的方法。 提供了可用于本发明实践的基因群体。
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4.发明申请Methods for determining whether an agent possesses a defined biological activity 审中-公开用于确定试剂是否具有确定的生物活性的方法公开(公告)号：US20050084872A1
公开(公告)日：2005-04-21
申请号：US10764420
申请日：2004-01-23
申请人： Pek Lum , Yejun Tan , Hongyue Dai , Eric Muise , Joel Berger , John Thompson
发明人： Pek Lum , Yejun Tan , Hongyue Dai , Eric Muise , Joel Berger , John Thompson
CPC分类号： G01N33/5014 , G01N33/48 , G01N2333/70567 , G16B25/00
摘要： In one aspect, the present invention provides methods for determining whether an agent (e.g., candidate drug) possesses a biological activity. In another aspect, the present invention provides populations of nucleic acid molecules useful in the practice of the present invention as probes for measuring the level of expression of populations of genes.
摘要翻译： 一方面，本发明提供了用于确定试剂（例如候选药物）是否具有生物活性的方法。 另一方面，本发明提供了可用于本发明实践的核酸分子群体，作为用于测量基因群体表达水平的探针。
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5.发明授权公开(公告)号：US08744778B2
公开(公告)日：2014-06-03
申请号：US13209156
申请日：2011-08-12
申请人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F. Raubertas , Kenny Kin Chung Wong
发明人： Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F. Raubertas , Kenny Kin Chung Wong
CPC分类号： C12Q1/6876 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158
摘要： In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.
摘要翻译： 在一个方面，本发明提供了确定试剂是否更像靶分子的部分激动剂而不是相同靶分子的完全激动剂的方法。 另一方面，本发明提供了选择可降低哺乳动物血浆葡萄糖浓度的候选化合物的方法。 提供了可用于本发明实践的基因群体。
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