公开(公告)号：US20150073388A1

公开(公告)日：2015-03-12

申请号：US14481583

申请日：2014-09-09

申请人： Maria PALASIS ,  Danny CONCAGH ,  Lee CORE ,  Stephanie WEBBER ,  Yina KUANG ,  Wendy NAIMARK ,  Raymond Knox

发明人： Maria PALASIS ,  Danny CONCAGH ,  Lee CORE ,  Stephanie WEBBER ,  Yina KUANG ,  Wendy NAIMARK ,  Raymond Knox

IPC分类号： A61M25/10 ,  A61M25/00

CPC分类号： A61M25/10 ,  A61F2/90 ,  A61F2250/0067 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61M2025/105 ,  A61M2025/1075 ,  C08L67/04

摘要： The present invention provides systems and methods for the targeted delivery of a therapeutic agent using expandable devices that are temporarily or permanently placed within the body. Such therapeutic agents may be delivered as a coating on the outer surface of the expandable device. Once positioned at a desired location within the body, the device is expanded such that its drug-coated outer surface establishes direct contact with a target tissue. The expanded device remains in contact with the target tissue for a pre-determined amount of time prior to being withdrawn from the body. Delivery of the therapeutic agent using the expandable device may be followed, or preceded, by delivery of a second expandable device to the same location within the body.

摘要翻译： 本发明提供了使用暂时或永久地放置在体内的可扩展装置来靶向递送治疗剂的系统和方法。 这样的治疗剂可以作为涂层递送到可扩张装置的外表面上。 一旦定位在身体内的期望位置，则该装置被扩张使得其药物涂覆的外表面与靶组织直接接触。 扩张的装置在从身体取出之前保持与目标组织接触预定的时间量。 可以通过将第二可扩张装置递送到身体内的相同位置，或之前进行使用该可扩张装置的治疗剂的递送。