公开(公告)号：US20150073388A1

公开(公告)日：2015-03-12

申请号：US14481583

申请日：2014-09-09

申请人： Maria PALASIS ,  Danny CONCAGH ,  Lee CORE ,  Stephanie WEBBER ,  Yina KUANG ,  Wendy NAIMARK ,  Raymond Knox

发明人： Maria PALASIS ,  Danny CONCAGH ,  Lee CORE ,  Stephanie WEBBER ,  Yina KUANG ,  Wendy NAIMARK ,  Raymond Knox

IPC分类号： A61M25/10 ,  A61M25/00

CPC分类号： A61M25/10 ,  A61F2/90 ,  A61F2250/0067 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61M2025/105 ,  A61M2025/1075 ,  C08L67/04

摘要： The present invention provides systems and methods for the targeted delivery of a therapeutic agent using expandable devices that are temporarily or permanently placed within the body. Such therapeutic agents may be delivered as a coating on the outer surface of the expandable device. Once positioned at a desired location within the body, the device is expanded such that its drug-coated outer surface establishes direct contact with a target tissue. The expanded device remains in contact with the target tissue for a pre-determined amount of time prior to being withdrawn from the body. Delivery of the therapeutic agent using the expandable device may be followed, or preceded, by delivery of a second expandable device to the same location within the body.

摘要翻译： 本发明提供了使用暂时或永久地放置在体内的可扩展装置来靶向递送治疗剂的系统和方法。 这样的治疗剂可以作为涂层递送到可扩张装置的外表面上。 一旦定位在身体内的期望位置，则该装置被扩张使得其药物涂覆的外表面与靶组织直接接触。 扩张的装置在从身体取出之前保持与目标组织接触预定的时间量。 可以通过将第二可扩张装置递送到身体内的相同位置，或之前进行使用该可扩张装置的治疗剂的递送。

公开(公告)号：US20100092448A1

公开(公告)日：2010-04-15

申请号：US12642300

申请日：2009-12-18

申请人： Toby FREYMAN ,  Wendy NAIMARK ,  Maria PALASIS

发明人： Toby FREYMAN ,  Wendy NAIMARK ,  Maria PALASIS

IPC分类号： A61K38/44 ,  A61K45/00 ,  A61K38/20 ,  A61K9/00 ,  A61K31/60 ,  A61K31/192 ,  A61K38/13 ,  A61P37/06

CPC分类号： A61F2/02 ,  A61F2/0077 ,  A61F2/07 ,  A61F2230/008 ,  A61F2250/0039 ,  A61F2250/0067

摘要： A medical device includes a carrier and an agent. The agent is formulated to control inflammation of biological tissue, such as heart tissue, and is releasably coupled to the carrier. The carrier is configured to be disposed in operative proximity to the biological tissue to be treated by the agent. In one embodiment, the carrier is configured to release the agent or otherwise deliver the agent to the biological tissue, thus controlling inflammation of the tissue. Also, a method to improve healing of biological tissue includes placing a medical device proximate to the heart of a patient, where the medical device has a carrier and an agent configured to control inflammation, the agent is releasably coupled to the carrier. In one embodiment, the method includes causing the agent to be released from the carrier.

摘要翻译： 医疗器械包括载体和药剂。 制剂用于控制诸如心脏组织的生物组织的炎症，并且可释放地联接到载体上。 载体被配置为设置在操作中接近要由药剂处理的生物组织。 在一个实施方案中，载体被配置为释放试剂或以其它方式将试剂递送到生物组织，从而控制组织的炎症。 此外，改善生物组织愈合的方法包括将医疗装置放置在靠近患者心脏的位置，其中医疗装置具有载体和被配置成控制炎症的药剂，药剂可释放地联接到载体上。 在一个实施例中，该方法包括使得试剂从载体释放。

公开(公告)号：US20080215137A1

公开(公告)日：2008-09-04

申请号：US11835787

申请日：2007-08-08

申请人： Samuel J. EPSTEIN ,  Irina OSTROVSKY-DAY ,  Wendy NAIMARK ,  Anastasia PANOS

发明人： Samuel J. EPSTEIN ,  Irina OSTROVSKY-DAY ,  Wendy NAIMARK ,  Anastasia PANOS

IPC分类号： A61F2/06

CPC分类号： A61L31/10 ,  A61F2/82 ,  A61F2250/0067 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/258 ,  A61L2300/608 ,  A61L2300/802

摘要： The present invention regards the delivery of therapeutic at a target site. Systems that employ the present invention may employ a medical device sized to be inserted into a target site, a driving layer covering at least a portion of an accessible surface of the medical device, and a therapeutic interfaced with at least a portion of the driving layer. In this system, the driving layer may have a material characteristic that serves to release the therapeutic from the medical device when the medical device is at the target site. Other systems that employ the invention may also have properties that include having a driving layer with a higher solubility than the therapeutic at the target site, a medical device that is hydrophobic while the therapeutic is hydrophilic, and a coating covering at least a portion of the therapeutic.

摘要翻译： 本发明涉及在靶位点递送治疗剂。 采用本发明的系统可以采用尺寸设计成可插入到目标部位的医疗装置，覆盖医疗装置的可接近表面的至少一部分的驱动层，以及与驱动层的至少一部分接合的治疗 。 在该系统中，当医疗装置在目标位置时，驱动层可以具有用于从医疗装置释放治疗剂的材料特性。 使用本发明的其它系统还可具有包括具有比目标部位的治疗剂具有更高溶解度的驱动层的性质，在治疗剂是亲水性时是疏水性的医疗装置，以及覆盖至少一部分 治疗。