公开(公告)号：US07365171B2

公开(公告)日：2008-04-29

申请号：US10859414

申请日：2004-06-02

申请人： Dalong Ma ,  Wenling Han ,  Yingme Zhang ,  Quansheng Song ,  Chunhui Di ,  Jiaqiang Huang ,  Jian Tang ,  Guanghui Chen

发明人： Dalong Ma ,  Wenling Han ,  Yingme Zhang ,  Quansheng Song ,  Chunhui Di ,  Jiaqiang Huang ,  Jian Tang ,  Guanghui Chen

IPC分类号： C07K14/52 ,  C07H21/04 ,  C12P21/04

CPC分类号： C07K14/521 ,  A61K38/00

摘要： The present invention provides chemokine-like factor (CKLF) polypeptides with chemotactic and hematopoietic stimulating activities and polynucleotides encoding such polypeptides. Additionally, a method for producing such CKLF polypeptides by recombinant techniques is provided. Also provided are the antibodies and antagonists against such polypeptides. The present invention further disclose a drug compound comprising a therapeutically effective amount of such CKLF polypeptides as well as pharmaceutically acceptable excipients and carriers. Also disclosed are the uses of such CKLF polypeptides and polynucleotides in diagnostics or therapeutics to treat immunodeficiency, hematopoietic diseases and primary tumors.

摘要翻译： 本发明提供具有趋化性和造血刺激活性的趋化因子样因子（CKLF）多肽和编码这些多肽的多核苷酸。 另外，提供了通过重组技术生产这种CKLF多肽的方法。 还提供了抗这种多肽的抗体和拮抗剂。 本发明还公开了包含治疗有效量的这种CKLF多肽以及药学上可接受的赋形剂和载体的药物化合物。 还公开了这样的CKLF多肽和多核苷酸在诊断或治疗中用于治疗免疫缺陷，造血疾病和原发性肿瘤的用途。