公开(公告)号：US20110076332A1

公开(公告)日：2011-03-31

申请号：US12807123

申请日：2010-08-27

申请人： Xiaojun Yu ,  Chandra M. Valmikinathan ,  Yixing Cheng

发明人： Xiaojun Yu ,  Chandra M. Valmikinathan ,  Yixing Cheng

IPC分类号： A61K9/14 ,  A61K31/722 ,  A01N43/16 ,  A61P31/00 ,  A01P15/00 ,  A61P19/02

CPC分类号： A61K9/0024 ,  A01N25/04 ,  A61K31/721 ,  A61K31/722 ,  A61K47/36

摘要： A biodegradable hydrogel comprises a water-soluble dextran having aldehyde groups cross-linked with a water-soluble chitosan. Various chemical agents may be encapsulated in the hydrogel or bonded thereto for controlled release. The hydrogel may be applied as a coating to reduce the likelihood of bacterial attachment and biofilm growth; used in tissue engineering applications to prevent tissue ingrowth; or used as a matrix in which cells may proliferate. The components of the hydrogel can be applied sequentially as a spray or by immersion and will gel spontaneously at environmental or physiological temperatures.

摘要翻译： 可生物降解的水凝胶包含具有与水溶性壳聚糖交联的醛基的水溶性葡聚糖。 各种化学试剂可以包封在水凝胶中或与其结合以便控制释放。 水凝胶可用作涂层以减少细菌附着和生物膜生长的可能性; 用于组织工程应用以防止组织向内生长; 或用作细胞可能增殖的基质。 水凝胶的组分可以作为喷雾或浸渍顺序施用，并且在环境或生理温度下自发凝胶化。