公开(公告)号：US20110076332A1

公开(公告)日：2011-03-31

申请号：US12807123

申请日：2010-08-27

申请人： Xiaojun Yu ,  Chandra M. Valmikinathan ,  Yixing Cheng

发明人： Xiaojun Yu ,  Chandra M. Valmikinathan ,  Yixing Cheng

IPC分类号： A61K9/14 ,  A61K31/722 ,  A01N43/16 ,  A61P31/00 ,  A01P15/00 ,  A61P19/02

CPC分类号： A61K9/0024 ,  A01N25/04 ,  A61K31/721 ,  A61K31/722 ,  A61K47/36

摘要： A biodegradable hydrogel comprises a water-soluble dextran having aldehyde groups cross-linked with a water-soluble chitosan. Various chemical agents may be encapsulated in the hydrogel or bonded thereto for controlled release. The hydrogel may be applied as a coating to reduce the likelihood of bacterial attachment and biofilm growth; used in tissue engineering applications to prevent tissue ingrowth; or used as a matrix in which cells may proliferate. The components of the hydrogel can be applied sequentially as a spray or by immersion and will gel spontaneously at environmental or physiological temperatures.

摘要翻译： 可生物降解的水凝胶包含具有与水溶性壳聚糖交联的醛基的水溶性葡聚糖。 各种化学试剂可以包封在水凝胶中或与其结合以便控制释放。 水凝胶可用作涂层以减少细菌附着和生物膜生长的可能性; 用于组织工程应用以防止组织向内生长; 或用作细胞可能增殖的基质。 水凝胶的组分可以作为喷雾或浸渍顺序施用，并且在环境或生理温度下自发凝胶化。

公开(公告)号：US20100310623A1

公开(公告)日：2010-12-09

申请号：US12455778

申请日：2009-06-05

申请人： Cato T. Laurencin ,  Xiaojun Yu ,  Chandra M. Valmikinathan ,  Junping Wang

发明人： Cato T. Laurencin ,  Xiaojun Yu ,  Chandra M. Valmikinathan ,  Junping Wang

IPC分类号： A61F2/28 ,  A61K38/18 ,  A61P19/00

CPC分类号： A61F2/28 ,  A61F2002/30062 ,  A61F2002/30235 ,  A61F2002/30293 ,  A61F2002/3084 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2230/0091 ,  A61F2310/00179 ,  A61L27/18 ,  A61L27/306 ,  A61L27/32 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2400/12 ,  A61L2430/02 ,  C08L67/04

摘要： An integrated scaffold for bone tissue engineering has a tubular outer shell and a spiral scaffold made of a porous sheet. The spiral scaffold is formed such that the porous sheet defines a series of spiral coils with gaps of controlled width between the coils to provide an open geometry for enhanced cell growth. The spiral scaffold resides within the bore of the shell and is integrated with the shell to fix the geometry of the spiral scaffold. Nanofibers may be deposited on the porous sheet to enhance cell penetration into the spiral scaffold. The spiral scaffold may have alternating layers of polymer and ceramic on the porous sheet that have been built up using a layer-by-layer method. The spiral scaffold may be seeded with cells by growing a cell sheet and placing the cell sheet on the porous sheet before it is rolled.

摘要翻译： 用于骨组织工程的综合支架具有管状外壳和由多孔片构成的螺旋支架。 形成螺旋支架，使得多孔片材限定一系列在线圈之间具有受控宽度间隙的螺旋线圈，以提供用于增强细胞生长的开放几何形状。 螺旋支架位于壳体的孔内，并与壳体整合以固定螺旋支架的几何形状。 纳米纤维可以沉积在多孔片上以增强细胞穿入螺旋支架。 螺旋支架可以在多孔片上具有聚合物和陶瓷的交替层，其已经使用逐层方法建立。 螺旋支架可以通过生长细胞片并将细胞片放置在多孔片材上之前将细胞接种在细胞上。