公开(公告)号：US4948908A

公开(公告)日：1990-08-14

申请号：US73447

申请日：1987-07-14

申请人： Moshe A. Frommer ,  Yoffi Segall ,  Ezra Shirin

发明人： Moshe A. Frommer ,  Yoffi Segall ,  Ezra Shirin

IPC分类号： A01N57/14 ,  A01N57/30 ,  C07F9/12 ,  C07F9/18 ,  C07F9/24

CPC分类号： C07F9/18 ,  A01N57/14 ,  A01N57/30 ,  C07F9/12 ,  C07F9/247

摘要： The invention relates to a new family of organophosphorus compounds. The compounds have a biological activity and can be used as insecticides. The compounds belong to the group of bis-aminophenyl phosphoric acid esters.

摘要翻译： 本发明涉及一种新的有机磷化合物家族。 这些化合物具有生物活性，可用作杀虫剂。 这些化合物属于双氨基苯基磷酸酯类。

公开(公告)号：US5407938A

公开(公告)日：1995-04-18

申请号：US137690

申请日：1993-10-14

申请人： Abraham Fisher ,  Yoffi Segall ,  Ezra Shirin ,  Yishai Karton ,  Haim Meshulam

发明人： Abraham Fisher ,  Yoffi Segall ,  Ezra Shirin ,  Yishai Karton ,  Haim Meshulam

IPC分类号： C07D471/10 ,  C07D471/20 ,  C07D491/10 ,  C07D497/10 ,  C07D498/10 ,  C07D498/20 ,  C07D513/10 ,  A61K31/44 ,  C07D491/20 ,  C07D495/20 ,  C07D497/20

CPC分类号： C07D471/10 ,  C07D491/10 ,  C07D497/10 ,  C07D513/10

摘要： The invention relates to compounds (I) for treating diseases of the central and peripheral nervous system, including enantiomers, racemates and acid addition and quaternary salts, ##STR1## wherein Q is selected from two H atoms, (CH.sub.2).sub.m and C(CH.sub.3).sub.2 where m is 1, 2 or 3 and n and p are; each independently 0, 1, 2 or 3, provided that n+p=1-3, and R.sup.0 is H, methyl or OH; the moiety ##STR2## R is selected from H, NH.sub.2, NH-C.sub.1-6 -alkyl, N(C.sub.1-6 -alkyl).sub.2, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl, C.sub.2-6 -alkynyl, C.sub.3-7 - cycloalkyl, C.sub.1-6 -alkyl substituted by 1-6 halogen atoms, hydroxy- C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio, C.sub.1-6 -alkoxy-C.sub.1-6 -alkyl, carboxy-C.sub.1-6 -alkyl, (C.sub.1-6 -alkoxy)carbonyl-C.sub.1-6 -alkyl, amino-C.sub.1-6 -alkyl, mono-(C.sub.1-6 -alkyl)amino-C.sub.1-6 -alkyl, di-(C.sub.1-6 -alkyl)amino-C.sub.1-6 -alkyl, 2-oxo-pyrrolidin-1-yl-methyl, aryl, diarylmethylol, and C.sub.1-6 -alkyl substituted by one or two aryl groups; R' is independently selected from the group from which R is selected and C.sub.1-6 -alkanoyl and arylcarbonyl; and aryl denotes unsubstituted phenyl or phenyl substituted by 1-3 substituents selected from halogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy and CF.sub.3, subject to certain provisos.

摘要翻译： 本发明涉及用于治疗中枢和周围神经系统疾病的化合物（I），包括对映体，外消旋体和酸加成和季盐。其中Q选自两个H原子，（CH 2）m和 C（CH 3）2，其中m为1,2或3，n和p为 每个独立地为0,1,2或3，条件是n + p = 1-3，R 0为H，甲基或OH; R 1选自H，NH 2，NH-C 1-6 - 烷基，N（C 1-6 - 烷基）2，C 1-6 - 烷基，C 2-6 - 烯基，C 2-6 - 炔基，C 3 -7-环烷基，被1-6个卤素原子取代的C 1-6 - 烷基，羟基-C 1-6 - 烷基，C 1-6 - 烷氧基，C 1-6 - 烷硫基，C 1-6 - 烷氧基-C 1-6 - 烷基， 羧基-C 1-6 - 烷基，（C 1-6 - 烷氧基）羰基-C 1-6 - 烷基，氨基-C 1-6 - 烷基，单 - （C 1-6 - 烷基）氨基-C 1-6 - 烷基， （C 1-6 - 烷基）氨基-C 1-6 - 烷基，2-氧代 - 吡咯烷-1-基 - 甲基，芳基，二芳基羟甲基和被一个或两个芳基取代的C 1-6 - 烷基; R'独立地选自选自R的基团和C 1-6 - 烷酰基和芳基羰基; 并且芳基表示未取代的苯基或被1-3个选自卤素，C 1-6 - 烷基，C 1-6 - 烷氧基和CF 3的取代基取代的苯基，具有一定条件。