公开(公告)号：US3958014A

公开(公告)日：1976-05-18

申请号：US343148

申请日：1973-03-20

申请人： Ryozo Watanabe ,  Tadakazu Suyama ,  Kazumasa Yokoyama ,  Yohei Odaka

发明人： Ryozo Watanabe ,  Tadakazu Suyama ,  Kazumasa Yokoyama ,  Yohei Odaka

IPC分类号： A61K9/00 ,  A61K31/02 ,  B01F17/00 ,  A61K45/00

CPC分类号： A61K9/0026 ,  A61K31/02 ,  B01F17/0028 ,  B01F17/0042 ,  Y10S514/937

摘要： An injectable fluorocarbon emulsion capable of carrying oxygen, which can be used as artificial blood and organ perfusate, is prepared by emulsifying a fluorocarbon, having an ability to dissolve at least 30 V/V % of oxygen under a 100% oxygen atmosphere at an atmospheric pressure, in an aqueous salt solution with a surfactant, centrifuging the resulting aqueous emulsion thereby to reduce the fluorocarbon particles in the emulsion in size to particle sizes of the order of about 0.05 to 0.25 .mu., and then sterilizing the thus obtained emulsion under rotation. The resulting fluorocarbon emulsion can be used as an emergency blood substitute for transfusion.

摘要翻译： 通过在大气压下在100％氧气气氛下乳化具有溶解至少30V / V％的氧的能力的碳氟化合物来制备能够携带氧气的可注射的氟化碳乳液，其可以用作人造血液和器官灌注液 压力，在含有表面活性剂的盐水溶液中离心所得水乳液，从而将乳液中的碳氟化合物颗粒尺寸减小到约0.05至0.25μm量级的粒度，然后在旋转下对由此获得的乳液进行灭菌。 所得氟碳乳液可用作输血的紧急血液替代品。