公开(公告)号：US06475506B1

公开(公告)日：2002-11-05

申请号：US09244931

申请日：1999-02-10

申请人： Tadaaki Inoue ,  Hideto Kodaira ,  Yoshihito Nawa ,  Ryoichiro Murashima ,  Shunichi Abe ,  Kazumasa Yokoyama

发明人： Tadaaki Inoue ,  Hideto Kodaira ,  Yoshihito Nawa ,  Ryoichiro Murashima ,  Shunichi Abe ,  Kazumasa Yokoyama

IPC分类号： A61K9107

CPC分类号： A61K33/30 ,  A23L33/115 ,  A23L33/16 ,  A23L33/175 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0029 ,  A61K31/70 ,  A61K45/06 ,  Y10S514/938 ,  Y10S514/943 ,  A61K33/14 ,  A61K33/06 ,  A61K31/7004 ,  A61K31/66 ,  A61K31/415 ,  A61K31/405 ,  A61K31/40 ,  A61K31/195 ,  A61K2300/00 ,  A23V2250/18 ,  A23V2200/222 ,  A23V2250/61 ,  A23V2250/6406 ,  A23V2250/0624 ,  A23V2250/156 ,  A23V2250/02 ,  A23V2250/06 ,  A23V2250/1944 ,  A23V2250/60 ,  A23V2250/64 ,  A23V2250/032

摘要： Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartment separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes. An infusion preparation containing a sugar, amino acids, electrolytes and a fat emulsion can be obtained easily and aseptically upon use, by simply removing a separation means attached to the container and mixing the two infusion liquids.

摘要翻译： 公开了用于营养供应使用的输液制剂。 它包含糖，氨基酸，电解质和脂肪乳剂。 尽管同时存在这些组分，它具有优异的保质期而不引起沉淀，变性等。 还公开了一种装有输注液体的容器，其包括通过分离装置彼此分离的第一和第二隔室，其中含有脂肪乳剂和糖的输注液体包含在第一隔室中，另一个输注液体含有氨基酸和 电解质被包括在第二隔室中。 还公开了包含脂肪乳剂和糖的输注制剂，以及包含氨基酸和电解质的输注制剂。 通过简单地除去附着在容器上的分离装置并混合两种输注液，可以容易地和无菌地获得含有糖，氨基酸，电解质和脂肪乳剂的输液制剂。

公开(公告)号：US5993863A

公开(公告)日：1999-11-30

申请号：US946359

申请日：1997-10-07

申请人： Masahiro Kikuchi ,  Yoshihiko Okutani ,  Tadaaki Inoue ,  Ryoichiro Murashima ,  Shunichi Abe ,  Hiroshi Koshiba ,  Hiroshi Shibata ,  Shunichiro Ishii ,  Yoshiyasu Kawabata ,  Kazumasa Yokoyama

发明人： Masahiro Kikuchi ,  Yoshihiko Okutani ,  Tadaaki Inoue ,  Ryoichiro Murashima ,  Shunichi Abe ,  Hiroshi Koshiba ,  Hiroshi Shibata ,  Shunichiro Ishii ,  Yoshiyasu Kawabata ,  Kazumasa Yokoyama

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K31/195 ,  A61K31/23 ,  A61K31/70 ,  A61K33/00 ,  A61K38/00 ,  A61P3/00 ,  A61P3/12 ,  A61K33/42 ,  A61K33/06 ,  A61K33/14 ,  A61K33/32

CPC分类号： A61K9/0029

摘要： The present invention aims at providing an alimentative infusion liquid which has improved stability and preservability and can be administered through a peripheral vein. The infusion liquid contains sugars, amino acids, electrolytes and a fat emulsion at a specific mixing ratio and has a specific pH value and a titratable acidity. The alimentative infusion liquid of the present invention containing the above-described components has good preservability without suffering from precipitation, denaturation and the like problems. Further, since the pH value is adjusted to a specific level and the titratable acidity is retained low, administration of the infusion liquid through a peripheral vein does not cause troubles such as angialiga.

摘要翻译： PCT No.PCT / JP94 / 00713 Sec。 371日期1995年10月25日第 102（e）日期1995年10月25日PCT 1994年4月27日PCT PCT。 公开号WO94 / 25059 日期：1994年11月10日本发明旨在提供一种具有改善的稳定性和保存性并可通过外周静脉施用的营养输液。 输注液体以特定的混合比含有糖，氨基酸，电解质和脂肪乳剂，并具有特定的pH值和可滴定的酸度。 含有上述成分的本发明的营养输液是具有良好的保存性，不会发生沉淀，变性等问题。 此外，由于将pH值调节到特定水平并且可滴定酸度保持较低，所以通过外周静脉施用输液不会引起诸如angialiga的麻烦。

公开(公告)号：US5972367A

公开(公告)日：1999-10-26

申请号：US475812

申请日：1995-06-07

申请人： Tadaaki Inoue ,  Hideto Kodaira ,  Yoshihito Nawa ,  Ryoichiro Murashima ,  Shunichi Abe ,  Kazumasa Yokoyama

发明人： Tadaaki Inoue ,  Hideto Kodaira ,  Yoshihito Nawa ,  Ryoichiro Murashima ,  Shunichi Abe ,  Kazumasa Yokoyama

IPC分类号： A23L1/29 ,  A23L1/30 ,  A23L1/304 ,  A23L1/305 ,  A61K9/00 ,  A61K31/70 ,  A61K33/30 ,  A61K45/06 ,  A61K9/107

CPC分类号： A61K33/30 ,  A23L33/115 ,  A23L33/16 ,  A23L33/175 ,  A23L33/40 ,  A61K31/70 ,  A61K45/06 ,  A61K9/0029 ,  A23V2002/00 ,  Y10S514/938 ,  Y10S514/943

摘要： Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes. An infusion preparation containing a sugar, amino acids, electrolytes and a fat emulsion can be obtained easily and aseptically upon use, by simply removing a separation means attached to the container and mixing the two infusion liquids.

摘要翻译： 公开了用于营养供应使用的输液制剂。 它包含糖，氨基酸，电解质和脂肪乳剂。 尽管同时存在这些组分，它具有优异的保质期而不引起沉淀，变性等。 还公开了一种装有输液的容器，其包括通过分离装置彼此分离的第一和第二隔室，其中含有脂肪乳液和糖的输注液体包含在第一隔室中，另一个输注液体含有氨基酸和 电解质被包括在第二隔室中。 还公开了包含脂肪乳剂和糖的输注制剂，以及包含氨基酸和电解质的输注制剂。 通过简单地除去附着在容器上的分离装置并混合两种输注液，可以容易地和无菌地获得含有糖，氨基酸，电解质和脂肪乳剂的输液制剂。

公开(公告)号：US5770233A

公开(公告)日：1998-06-23

申请号：US437330

申请日：1995-04-21

申请人： Takae Kido ,  Shigeo Ii ,  Shun-ichi Abe ,  Kazumasa Yokoyama

发明人： Takae Kido ,  Shigeo Ii ,  Shun-ichi Abe ,  Kazumasa Yokoyama

IPC分类号： A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61K9/00 ,  A61K9/08 ,  A61K9/107 ,  A61K31/045 ,  A61K31/047 ,  A61K31/07 ,  A61K31/12 ,  A61K31/122 ,  A61K31/195 ,  A61K31/197 ,  A61K31/20 ,  A61K31/23 ,  A61K31/355 ,  A61K31/375 ,  A61K31/44 ,  A61K31/505 ,  A61K31/51 ,  A61K31/525 ,  A61K31/59 ,  A61K31/70 ,  A61K31/714 ,  A61K33/00 ,  A61K38/00 ,  A61K45/06 ,  A61P3/00 ,  A61P3/12 ,  A61P25/04 ,  A61K31/34 ,  A61K31/595

CPC分类号： A61K9/0029 ,  A61J1/2093 ,  A61K45/06 ,  A61J1/10 ,  A61J1/2034

摘要： An object of the present invention is to provide an infusion preparation set (a container filled with infusion liquids) useful for preparation of an infusion liquid containing sugars, amino acids, electrolytes, a fat emulsion and vitamins. The present invention is constituted by the use of a container having two compartments which are separated from each other by a separation means, which contains an infusion liquid comprising a fat emulsion, sugars, fat-soluble vitamins and specified water-soluble vitamins in the first compartment and an infusion liquid comprising amino acids, electrolytes and other specified water-soluble vitamins in the second compartment. An infusion preparation containing sugars, amino acids, electrolytes, a fat emulsion and vitamins can be obtained easily and aseptically upon use, by simply removing a separation means and mixing the infusion liquids included in the first and second compartments. Further, the components of the infusion liquids included in each compartment have good stability.

公开(公告)号：US5610169A

公开(公告)日：1997-03-11

申请号：US474549

申请日：1995-06-07

申请人： Toru Iwao ,  Kenichi Hirai ,  Nobuo Kondoh ,  Koichi Yamanouchi ,  Kazumasa Yokoyama

发明人： Toru Iwao ,  Kenichi Hirai ,  Nobuo Kondoh ,  Koichi Yamanouchi ,  Kazumasa Yokoyama

IPC分类号： A61K9/08 ,  A61K9/14 ,  A61K9/16 ,  A61K9/18 ,  A61K31/047 ,  A61K31/05 ,  A61K31/085 ,  A61K31/10 ,  A61K31/12 ,  A61K31/165 ,  A61K31/195 ,  A61K31/215 ,  A61K31/22 ,  A61K31/23 ,  A61K31/44 ,  A61K31/4422 ,  A61K31/455 ,  A61K31/495 ,  A61K47/02 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61P43/00 ,  A61K47/00

CPC分类号： A61K31/495 ,  A61K31/085 ,  A61K31/10 ,  A61K31/12 ,  A61K31/165 ,  A61K31/215 ,  A61K31/44 ,  A61K47/14 ,  A61K47/26 ,  A61K9/143 ,  A61K9/145 ,  A61K9/1605 ,  Y10S514/946

摘要： The orally administrable pharmaceutical compositions containing a slightly water-soluble drug, characterized by improved stability and improved absorption of the drug from digestive tract into blood. The use of the compositions of the present invention enables decrease of the dose amount of a slightly water-soluble drug, which eventually leads to alleviation of pains and side effects on the part of patients.

摘要翻译： 含有轻微水溶性药物的可口服给药的药物组合物，其特征在于改善药物从消化道到血液中的稳定性和改善的吸收。 使用本发明的组合物能够减少轻微水溶性药物的剂量，其最终导致患者部分疼痛和副作用的缓解。

公开(公告)号：US5462951A

公开(公告)日：1995-10-31

申请号：US115785

申请日：1993-09-03

申请人： Toru Iwao ,  Kenichi Hirai ,  Nobuo Kondoh ,  Koichi Yamanouchi ,  Kazumasa Yokoyama

发明人： Toru Iwao ,  Kenichi Hirai ,  Nobuo Kondoh ,  Koichi Yamanouchi ,  Kazumasa Yokoyama

IPC分类号： A61K9/08 ,  A61K9/14 ,  A61K9/16 ,  A61K9/18 ,  A61K31/047 ,  A61K31/05 ,  A61K31/085 ,  A61K31/10 ,  A61K31/12 ,  A61K31/165 ,  A61K31/195 ,  A61K31/215 ,  A61K31/22 ,  A61K31/23 ,  A61K31/44 ,  A61K31/4422 ,  A61K31/455 ,  A61K31/495 ,  A61K47/02 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61P43/00 ,  A61K47/00

CPC分类号： A61K31/495 ,  A61K31/085 ,  A61K31/10 ,  A61K31/12 ,  A61K31/165 ,  A61K31/215 ,  A61K31/44 ,  A61K47/14 ,  A61K47/26 ,  A61K9/143 ,  A61K9/145 ,  A61K9/1605 ,  Y10S514/946

摘要： The orally administrable pharmaceutical compositions containing a slightly water-soluble drug, characterized by improved stability and improved absorption of the drug from digestive tract into blood. The use of the compositions of the present invention enables decrease of the dose amount of a slightly water-soluble drug, which eventually leads to alleviation of pains and side effects on the part of patients.

摘要翻译： 含有轻微水溶性药物的可口服给药的药物组合物，其特征在于改善药物从消化道到血液中的稳定性和改善的吸收。 使用本发明的组合物能够减少轻微水溶性药物的剂量，其最终导致患者部分疼痛和副作用的缓解。

公开(公告)号：US5440018A

公开(公告)日：1995-08-08

申请号：US36387

申请日：1993-03-24

申请人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Fuluhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Munehiro Noda ,  Masahide Kondo ,  Syoichi Ishikawa ,  Kazuhiro Oohara ,  Kazumasa Yokoyama

发明人： Takao Ohmura ,  Akinori Sumi ,  Wataru Ohtani ,  Naoto Fuluhata ,  Kazuya Takeshima ,  Kaeko Kamide ,  Munehiro Noda ,  Masahide Kondo ,  Syoichi Ishikawa ,  Kazuhiro Oohara ,  Kazumasa Yokoyama

IPC分类号： A61K38/00 ,  C07K1/14 ,  C07K14/765 ,  C12N15/14 ,  A61K38/38 ,  C07K1/16 ,  C07K1/36

CPC分类号： C07K14/765 ,  A61K38/00

摘要： Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatment and another ultrafiltration, followed by subsequent treatments with a cation exchanger, a hydrophobic chromatography carrier and an anion exchanger, and by salting-out to thereby obtain a pure form of human serum albumin which contains substantially no proteinous and polysaccharide contaminants, which is formulated into a pharmaceutical preparation. This process makes it possible to effeciently purify recombinant human serum albumin and to provide substantially pure human serum albumin which does not contain producer host-related substances and other contaminants and is sufficiently free from coloration.

摘要翻译： 通过基因操作技术获得的人血清白蛋白可以通过特定步骤的组合来纯化，其中将得自人血清白蛋白的宿主的培养上清液进行超滤，热处理，酸处理和另一次超滤，然后用 阳离子交换剂，疏水性色谱载体和阴离子交换剂，并通过盐析，从而获得纯的形式的人血清白蛋白，其基本上不含有配制成药物制剂的蛋白质和多糖污染物。 该方法使得可以有效地纯化重组人血清白蛋白并提供基本上纯的人血清白蛋白，其不含生产者宿主相关物质和其它污染物，并且没有着色。

公开(公告)号：US4916130A

公开(公告)日：1990-04-10

申请号：US241447

申请日：1988-09-08

申请人： Masakazu Iwai ,  Chikara Fukaya ,  Kazumasa Yokoyama

发明人： Masakazu Iwai ,  Chikara Fukaya ,  Kazumasa Yokoyama

IPC分类号： A61K31/16

CPC分类号： A61K31/16

摘要： An antithrombotic composition containing an amide derivative which is obtained by binding a sulfur-containing amine to an unsaturated fatty acid having 4 to 13 carbon atoms through an amide bond and which exerts a high platelet agglutination-inhibiting effect.

公开(公告)号：US4868318A

公开(公告)日：1989-09-19

申请号：US023365

申请日：1987-03-09

申请人： Kirby V. Scherer, Jr. ,  Taizo Ono ,  Kouichi Yamanouchi ,  Kazumasa Yokoyama

发明人： Kirby V. Scherer, Jr. ,  Taizo Ono ,  Kouichi Yamanouchi ,  Kazumasa Yokoyama

IPC分类号： C07C43/12 ,  C07C43/192 ,  C07D307/79 ,  C07D317/16 ,  C07D319/20 ,  C07D321/08 ,  C07D493/08

CPC分类号： C07D307/79 ,  C07C43/123 ,  C07C43/192 ,  C07D317/16 ,  C07D319/20 ,  C07D321/08 ,  C07D493/08

摘要： The present invention relates to novel perfluoro chemicals (PFC), particularly perfluorocyclic ethers and polyfluorinated compounds containing a few chlorine atoms and to a method for the preparation thereof.

摘要翻译： 本发明涉及新型全氟化合物（PFC），特别是含有少量氯原子的全氟环醚和多氟化合物及其制备方法。

公开(公告)号：US4849429A

公开(公告)日：1989-07-18

申请号：US906268

申请日：1986-09-09

申请人： Chikara Fukaya ,  Atsuyuki Ashimori ,  Taizo Ono ,  Kazumasa Yokoyama

发明人： Chikara Fukaya ,  Atsuyuki Ashimori ,  Taizo Ono ,  Kazumasa Yokoyama

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D401/14

摘要： There is provided a dihydropyridine derivative having the formula ##STR1## wherein R'.sub.1 denotes methyl, chlorine, bromine, fluorine, trifluoromethyl, nitro, cyano or methoxy, R.sub.7 denotes benzyl; and the dihydropyridine links to the 2-, 3-, or 4-position of the pyridine.The compound has an activity as a Ca-antagonist, and is useful for treating vascular disorders such as coronary artery disease, celebral artery disease, hypertension and the like.

摘要翻译： 提供具有式“IMAGE”的二氢吡啶衍生物，其中R'1表示甲基，氯，溴，氟，三氟甲基，硝基，氰基或甲氧基，R7表示苄基; 并且二氢吡啶与吡啶的2-，3-或4-位相连。 该化合物具有作为Ca拮抗剂的活性，可用于治疗血管疾病如冠状动脉疾病，冠状动脉疾病，高血压等。