公开(公告)号：US20050260261A1

公开(公告)日：2005-11-24

申请号：US11133879

申请日：2005-05-19

申请人： Shi Huang ,  Samuel Zalipsky ,  Wei-Ming Zhang ,  Bei Jin ,  Yolanda Quinn

发明人： Shi Huang ,  Samuel Zalipsky ,  Wei-Ming Zhang ,  Bei Jin ,  Yolanda Quinn

IPC分类号： C07D233/02 ,  A61K9/127 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/22 ,  A61K47/44 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54

CPC分类号： A61K9/1271 ,  A61K9/1272 ,  A61K47/542 ,  A61K47/543 ,  A61K48/00 ,  C07D233/54 ,  C07D233/64 ,  Y10T428/2984

摘要： A lipid represented by the formula: wherein each of R1 and R2 is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0-20; L is selected from the group consisting of (i) —X—(C═O)—Y—, (ii) —X—(C═O)—, and (iii) —X—CH2—, wherein X and Y are independently selected from oxygen, NH and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0 is described.

摘要翻译： 由下式表示的脂质：其中R 1和R 2各自为具有约8至约24个碳原子的烷基或链烯基链; n = 0-20; L选自（i）-X-（CO）-Y-，（ii）-X-（CO） - 和（iii）-X-CH 2 - 其中X和Y独立地选自氧，NH和直接键; 并且Z是具有小于约7.4且大于约4.0的pK的弱碱性部分。