公开(公告)号：US20090176315A1

公开(公告)日：2009-07-09

申请号：US11990645

申请日：2006-08-16

Applicant: Jongyoon Han ,  Yong-Ak Song

Inventor： Jongyoon Han ,  Yong-Ak Song

IPC: G01N1/18 ,  B01L3/00 ,  B03C9/00

CPC classification number: G01N27/44795 ,  Y10T436/25375

Abstract: This invention is directed to methods and devices for separating molecules in a sample, based on differences in their isoelectric point (pI). The methods and devices make use of a diffusion potential created in a microfluidic chamber when a buffered solution comprising molecules, which differ in terms of their isoelectric point (pI) values and a second buffer, which differs from the buffered solution in terms of its pH or salt concentration are introduced in the chamber. The diffusion potential, in turn, enables charge-based separation of the molecules. Applications and permutations of the methods and devices are described.

Abstract translation: 本发明涉及根据其等电点（pI）的差异来分离样品中的分子的方法和装置。 当包含分子的缓冲溶液（其等电点（pI）值不同）和第二缓冲液（其在pH值方面不同于缓冲溶液）时，所述方法和装置利用在微流体室中产生的扩散电位 或盐浓度引入室中。 扩散电位又可以使分子的电荷分离。 描述了方法和设备的应用和排列。

公开(公告)号：US20110251652A1

公开(公告)日：2011-10-13

申请号：US13083014

申请日：2011-04-08

Applicant: Jongyoon Han ,  Yong-Ak Song ,  Amr Rabie ,  Rahul Sarpeshkar ,  Samuel J. Lin

Inventor： Jongyoon Han ,  Yong-Ak Song ,  Amr Rabie ,  Rahul Sarpeshkar ,  Samuel J. Lin

IPC: A61N1/36 ,  C12N13/00

CPC classification number: A61N1/3605 ,  A61N1/0553 ,  A61N1/36071 ,  A61N1/361

Abstract: A neural prosthetic device is provided that includes one or more ion-selective membranes enabling electrically-controlled local modulation of ion concentrations around a nerve so as to achieve different excitability states of the nerve for electrical stimulation or inhibition of nerve signal propagation.

Abstract translation: 提供神经假体装置，其包括一个或多个离子选择膜，其能够对神经周围的离子浓度进行电控局部调制，以实现用于电刺激或抑制神经信号传播的神经的不同兴奋性状态。

公开(公告)号：US20090120796A1

公开(公告)日：2009-05-14

申请号：US12239438

申请日：2008-09-26

Applicant: Jongyoon Han ,  Yong-Ak Song ,  Jeong Hoon Lee

Inventor： Jongyoon Han ,  Yong-Ak Song ,  Jeong Hoon Lee

IPC: B01D69/10 ,  G01N1/40

CPC classification number: G01N27/44743 ,  B01L3/502707 ,  B01L2300/0636 ,  B01L2300/087 ,  B01L2300/12 ,  G01N2001/4038

Abstract: The present invention provides a device and methods of use thereof in concentrating a species of interest and/or controlling liquid flow in a device. The methods, inter-alia, make use of a device comprising a fluidic chip comprising a planar array of channels through which a liquid comprising a species of interest can be made to pass with at least one rigid substrate connected thereto such that at least a portion of a surface of the substrate bounds the channels, and an ion-selective membrane is attached to at least a portion of the surface of the substrate, which bounds said channels, or which bounds a portion of a surface of one of said channels. The device comprises a unit to induce an electric field in the channel and a unit to induce an electrokinetic or pressure driven flow in the channel.

Abstract translation: 本发明提供了一种装置及其使用方法，用于在感兴趣的物质和/或控制装置中的液体流中浓缩。 所述方法尤其利用包括流体芯片的装置，该流体芯片包括平坦的通道阵列，通过该平面阵列阵列可以使包含感兴趣的物质的液体与连接到其上的至少一个刚性基板通过，使得至少一部分 所述衬底的表面限定所述通道，并且离子选择性膜连接到所述衬底的表面的至少一部分，所述表面限定所述通道，或限定所述通道之一的表面的一部分。 该装置包括用于在通道中诱导电场的单元和用于在通道中诱导电动或压力驱动流的单元。