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公开(公告)号:US20190234530A1
公开(公告)日:2019-08-01
申请号:US16330118
申请日:2017-09-11
CPC分类号: F16K99/0015 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2300/049 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , F16K99/0057 , F16K2099/0084
摘要: A single-layer valve is provided. The valve comprises a microfluidic pathway at least partially defined by a flexible membrane which is configured to deform when subjected to an actuation torque, and a discontinuity bounded by a first surface. The length of the discontinuity is constant across the full width of the first surface. The valve is configured such that the actuation torque on the membrane is larger in a first direction than a second direction substantially opposite to the first direction.
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公开(公告)号:US20190233887A1
公开(公告)日:2019-08-01
申请号:US16225720
申请日:2018-12-19
发明人: Jon A. HOSHIZAKI , Joon Mo YANG , Maryam SHARIATI , David M. COX , Kirk M. HIRANO , John BRIDGHAM , George Stefan GOLDA , Sam Lee WOO
IPC分类号: C12Q1/6869 , G01N35/10 , B01F13/00 , B01F13/02 , B01J19/00 , C12Q1/6874 , B01L3/00 , G01N35/00
CPC分类号: C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要: Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 μl). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.
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公开(公告)号:US20190232569A1
公开(公告)日:2019-08-01
申请号:US16378440
申请日:2019-04-08
申请人: Picosys Incorporated
发明人: Raymond Miller Karam , Georges Roussos , Mark Finkle , Daniella M. Harvey , Pascal R. Ackermann-Karam
IPC分类号: B29C65/16 , B23K26/244 , B29C65/00 , B23K37/04 , C03B23/203 , B29C65/78 , B23K26/211 , B23K26/32 , B23K26/0622 , B23K26/082 , C03C27/00 , B23K26/324 , B01L3/00 , B23K26/08 , B23K26/046 , B23K26/03 , B32B37/06
CPC分类号: B29C65/1612 , B01L3/502707 , B01L2200/12 , B01L2300/0887 , B23K26/032 , B23K26/046 , B23K26/0622 , B23K26/082 , B23K26/0853 , B23K26/211 , B23K26/244 , B23K26/32 , B23K26/324 , B23K37/0435 , B23K2101/18 , B23K2101/40 , B23K2103/18 , B23K2103/42 , B23K2103/50 , B23K2103/52 , B23K2103/54 , B29C65/1635 , B29C65/1638 , B29C65/1654 , B29C65/1683 , B29C65/7841 , B29C65/7847 , B29C66/1122 , B29C66/45 , B29C66/73161 , B29C66/7392 , B29C66/7465 , B32B37/06 , B32B2307/412 , B32B2310/0843 , B32B2315/08 , C03B23/203 , C03C27/00
摘要: A process for room temperature substrate bonding employs a first substrate substantially transparent to a laser wavelength is selected. A second substrate for mating at an interface with the first substrate is then selected. A transmissivity change at the interface is created and the first and second substrates are mated at the interface. The first substrate is then irradiated with a laser of the transparency wavelength substantially focused at the interface and a localized high temperature at the interface from energy supplied by the laser is created. The first and second substrates immediately adjacent the interface are softened with diffusion across the interface to fuse the substrates.
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公开(公告)号:US20190219078A1
公开(公告)日:2019-07-18
申请号:US16361835
申请日:2019-03-22
发明人: Dino Di Carlo , Hamed Amini , Elodie Sollier
CPC分类号: F15D1/14 , B01J19/0093 , B01J2219/00855 , B01J2219/00889 , B01J2219/00995 , B01L3/502707 , B01L3/502776 , B01L7/00 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2400/086 , Y10T137/0324 , Y10T137/86928
摘要: A microfluidic platform is disclosed that uses obstacles placed at particular location(s) within the channel cross-section to turn and stretch fluid. The asymmetric flow behavior upstream and downstream of the obstacle(s) due to fluid inertia manifests itself as a total deformation of the topology of streamlines that effectively creates a tunable net secondary flow. The system and methods passively creates strong secondary flows at moderate to high flow rates in microchannels. These flows can be accurately controlled by the numbers and particular geometric placement of the obstacle(s) within the channel.
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公开(公告)号:US20190187123A1
公开(公告)日:2019-06-20
申请号:US16282463
申请日:2019-02-22
IPC分类号: G01N33/487 , B01L3/00
CPC分类号: G01N33/48721 , B01L3/502707 , B01L3/502761 , B01L2200/0663 , B01L2300/0896 , B01L2400/0415 , G01N27/44791
摘要: Devices for controlling the capture, trapping, and transport of macromolecules include at least one fluidic transport nanochannel that intersects and is in fluid communication with at least one transverse nanochannel with (shallow) regions and/or with integrated transverse electrodes that enable fine control of molecule transport dynamics and facilitates analyses of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
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公开(公告)号:US20190022650A1
公开(公告)日:2019-01-24
申请号:US15792732
申请日:2017-10-24
发明人: Steven Barcelo , Anita Rogacs , Viktor Shkolnikov , Milo Overbay
CPC分类号: B01L3/502738 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L9/527 , B01L2200/0647 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0433 , B01L2400/0442 , B29C39/006 , G01N21/6486 , G01N21/658 , G01N2021/651
摘要: A microfluidic chip may include a substrate, chamber supported by the substrate, a sacrificial material in the chamber, a spectroscopically active nano particle assembly anchored within the chamber by the sacrificial material and a fluid supply port connected to the chamber. Each spectroscopically active nano particle assembly may include a cluster of nanoparticles.
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公开(公告)号:US20180353959A1
公开(公告)日:2018-12-13
申请号:US16004676
申请日:2018-06-11
发明人: John A. Verrant , John N. Blum , Vu Phan , Kaushal K. Verma , Elise G. Edson
CPC分类号: B01L3/502715 , B01F5/0614 , B01F5/0618 , B01F5/0646 , B01F5/0647 , B01F5/0652 , B01F13/0059 , B01F2005/0632 , B01F2005/0633 , B01F2215/0037 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/028 , B01L2200/0621 , B01L2200/0684 , B01L2300/045 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/168 , B01L2400/0406 , B01L2400/0478 , B01L2400/0481 , B01L2400/0484 , B01L2400/0487 , B01L2400/0633 , B01L2400/065 , B01L2400/0655 , B01L2400/086
摘要: A biological fluid sample analysis cartridge is provided. The cartridge includes a housing, a fluid module, and an analysis chamber. The fluid module includes a sample acquisition port and an initial channel, and is connected to the housing. The initial channel is sized to draw fluid sample by capillary force, and is in fluid communication with the acquisition port. The initial channel is fixedly positioned relative to the acquisition port such that at least a portion of a fluid sample disposed within the acquisition port will draw into the initial channel. The analysis chamber is connected to the housing, and is in fluid communication with the initial channel.
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公开(公告)号:US20180346860A1
公开(公告)日:2018-12-06
申请号:US15995360
申请日:2018-06-01
发明人: Nancy Allbritton , Yuli Wang , Christopher Sims
CPC分类号: C12M23/16 , B01L3/5027 , B01L3/502707 , B01L2200/0684 , B01L2200/12 , B01L2300/161 , B81B2201/058 , B81C1/00206 , C12M23/12 , C12M29/20 , C12Q1/02 , G01N2035/00158
摘要: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.
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公开(公告)号:US20180326416A1
公开(公告)日:2018-11-15
申请号:US15776872
申请日:2016-11-22
CPC分类号: B01L3/502707 , B01L2300/0816 , B01L2300/0822 , B01L2300/168 , B01L2400/0487 , B01L2400/049 , B29C64/135 , B29C64/35 , B29C67/00 , B29K2995/0056 , B29L2031/756 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要: Microfluidics has advanced in terms of designs and structures, however, fabrication methods are either time consuming or expensive to produce, in terms of the facilities and equipment needed. A fast and economically viable method is provided to allow, for example, research groups to have access to microfluidic fabrication. Unlike most fabrication methods, a method is provided to fabricate a microfluidic device in one step. In an embodiment, a resolution of 50 micrometers was achieved by using maskless high-resolution digital light projection (MDLP). Bonding and channel fabrication of complex or simple structures can be rapidly incorporated to fabricate the microfluidic devices.
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公开(公告)号:US10071375B2
公开(公告)日:2018-09-11
申请号:US15277889
申请日:2016-09-27
发明人: Jaione Tirapu Azpiroz , Peter William Bryant , Rodrigo Neumann Barros Ferreira , Ronaldo Giro , Ricardo Luis Ohta
CPC分类号: B01L3/502746 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/06 , B01L2200/0652 , B01L2200/0668 , B01L2200/12 , B01L2300/0645 , B01L2300/123 , B01L2400/0661 , B01L2400/082 , B01L2400/086 , B81B1/006 , B81B2201/058 , B81B2203/0361 , B81C1/00111 , F16B1/0014
摘要: A microfluidic device, including a substrate including a microchannel, an activation setup disposed in the microchannel, and a matrix array of controllable shape-changing micropillars connected to the activation setup. A shape of the controllable shape-changing micropillars changes based on an activation of the activation setup.
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