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公开(公告)号：US07971753B2
公开(公告)日：2011-07-05
申请号：US10578916
申请日：2004-09-17
CPC分类号： B65D83/0055 , A61F9/0008 , A61J1/145 , A61J1/1456 , A61J1/1468 , B65D47/18
摘要： A filter-equipped container which, particularly in a small-sized eyedrop bottle or the like, is capable of accurate dropping while preventing bubbles from being involved when a contents liquid is to be delivered through a delivery port. To solve such problem, a plug body 12 disposed in the mouth of a bottle 10 is provided with a delivery passage for delivering contents liquid received in the bottle 10, the delivery passage being provided with a filter 25. The filter 25 is composed of a filter film 25a for filtering bacteria to prevent the latter from permeating from upstream to downstream as seen in the direction of delivery, and a contents liquid holding member 25b of porous material that has microscopic pores, disposed upstream of the filter film 25a, the contents liquid holding member 25b being in planar contact with the filter film 25a.
摘要翻译： 特别是在小尺寸的眼药瓶等中的过滤装置的容器能够在通过输送口输送内容物时防止气泡受到正确的滴落。 为了解决这样的问题，设置在瓶10的口部的塞体12设置有用于输送容纳在瓶子10中的内容物的输送通道，输送通道设置有过滤器25.过滤器25由 用于过滤细菌以防止其从输送方向上游流向下游的过滤膜25a和设置在过滤膜25a上游的微孔的多孔材料的内容物保持部件25b，内容物液体 保持构件25b与过滤膜25a平面接触。
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公开(公告)号：US20060234945A1
公开(公告)日：2006-10-19
申请号：US10540446
申请日：2003-12-24
申请人： Teruo Nishida , Yorihisa Uetake , Hiroaki Iwata
发明人： Teruo Nishida , Yorihisa Uetake , Hiroaki Iwata
IPC分类号： A61K38/08
CPC分类号： C07K14/78 , A61K9/0048 , A61K38/08
摘要： An object is to find the minimum activity expression site of fibronectin, clarify the actions of this minimum unit in relation to ophthalmological fields, and provide a ophthalmological composition having this minimum unit as an effective component. This invention provides an ophthalmological composition, in particular, a corneal disorder treatment agent containing the peptide, PHSRN (SEQ ID NO: 1)(Pro-His-Ser-Arg-Asn (SEQ ID NO: 1)), or Ac-Pro-His-Ser-Arg-Asn-NH2, which is a derivative thereof, or a salt thereof that is allowable as a medical drug as an effective component. The preferred dosage form is an ophthalmic formulation.
摘要翻译： 目的是找到纤维连接蛋白的最小活性表达位点，阐明该最小单位与眼科领域相关的作用，并提供具有该最小单位作为有效成分的眼科学组合物。 本发明提供了一种眼科学组合物，特别是含有肽PHSRN（SEQ ID NO：1）（Pro-His-Ser-Arg-Asn（SEQ ID NO：1））或Ac-Pro的角膜病症治疗剂 作为其药物作为有效成分允许的作为其衍生物的盐酸-His-Ser-Arg-Asn-NH 2或其盐。 优选的剂型是眼用制剂。
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公开(公告)号：US09422100B2
公开(公告)日：2016-08-23
申请号：US14398010
申请日：2012-05-09
CPC分类号： B65D83/0094 , A61F9/0008 , A61J1/1443 , B65D47/18 , B65D47/2075 , B65D47/2093 , B65D51/1616 , B65D83/0055
摘要： A filtering discharge container employing a delaminatable bottle was provided, which reliably prevents a content liquid from leaking out before the first use, and reduces a discharging resistance during the second and subsequent use. An engagement portion (31c) is provided in an outlet passage of a mouth cap (3). A plug (34) is engaged with the engagement portion (31c) in such a manner that the plug (34) can be disengaged from the engagement portion (31c) by an internal pressure of an inner layer bag (22) increased by squeeze-deforming a body of an outer layer bottle (21). The outlet passage is closed with the plug (34) engaged with the engagement portion (31c). After the plug (34) is disengaged from the engagement portion (31c), liquid communication is established between the inside of the inner layer bag (22) and a filter (33).
摘要翻译： 提供了使用可分层瓶子的过滤排放容器，其可靠地防止内容物在第一次使用之前泄漏，并且在第二次和随后的使用期间降低了排出阻力。 在口盖（3）的出口通道中设置有接合部分（31c）。 插塞（34）与接合部（31c）接合，使得插塞（34）能够通过挤压成型的内层袋（22）的内部压力与接合部分（31c）脱离接合， 使外层瓶（21）的主体变形。 出口通道用与接合部分（31c）接合的塞子（34）关闭。 在插头（34）从接合部分（31c）脱离之后，在内层袋（22）的内部和过滤器（33）之间建立液体连通。
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公开(公告)号：US20150216723A1
公开(公告)日：2015-08-06
申请号：US14397948
申请日：2012-05-09
CPC分类号： A61F9/0008 , B65D47/0804 , B65D47/128 , B65D47/18 , B65D47/2031 , B65D47/2075 , B65D47/2093 , B65D47/247
摘要： A plug member integrally includes a base portion (35a) attached to a plug holder (31) to be mounted on a mouth portion of a container, a plug (34) engaged with an engagement portion (31c) provided in an outlet passage of the plug holder (31), and a resilient connection portion (35b) resiliently connecting the plug (34) to the base portion (35a). Before the first use, the outlet passage is closed with the plug member. In the first use, the container is squeezed to increase the internal pressure of the container. Thus, the plug (34) is disengaged from the engagement portion (31c) by the internal pressure. The outlet passage is thereafter constantly kept open.
摘要翻译： 插塞构件一体地包括安装在容纳器的口部的插头保持架（31）上的基部（35a），与设置在容器的出口通路上的卡合部（31c）卡合的插头 插头保持器（31）和弹性地将插头（34）连接到基部（35a）的弹性连接部分（35b）。 在第一次使用之前，出口通道用插塞构件封闭。 在第一次使用时，容器被挤压以增加容器的内部压力。 因此，插头（34）通过内部压力与接合部分（31c）脱离。 出口通道此后不断保持打开。
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公开(公告)号：US20150122845A1
公开(公告)日：2015-05-07
申请号：US14398010
申请日：2012-05-09
CPC分类号： B65D83/0094 , A61F9/0008 , A61J1/1443 , B65D47/18 , B65D47/2075 , B65D47/2093 , B65D51/1616 , B65D83/0055
摘要： A filtering discharge container employing a delaminatable bottle was provided, which reliably prevents a content liquid from leaking out before the first use, and reduces a discharging resistance during the second and subsequent use. An engagement portion (31c) is provided in an outlet passage of a mouth cap (3). A plug (34) is engaged with the engagement portion (31c) in such a manner that the plug (34) can be disengaged from the engagement portion (31c) by an internal pressure of an inner layer bag (22) increased by squeeze-deforming a body of an outer layer bottle (21). The outlet passage is closed with the plug (34) engaged with the engagement portion (31c). After the plug (34) is disengaged from the engagement portion (31c), liquid communication is established between the inside of the inner layer bag (22) and a filter (33).
摘要翻译： 提供了使用可分层瓶子的过滤排放容器，其可靠地防止内容物在第一次使用之前泄漏，并且在第二次和随后的使用期间降低了排出阻力。 在口盖（3）的出口通道中设置有接合部分（31c）。 插塞（34）与接合部（31c）接合，使得插塞（34）能够通过挤压成型的内层袋（22）的内部压力与接合部分（31c）脱离接合， 使外层瓶（21）的主体变形。 出口通道用与接合部分（31c）接合的塞子（34）关闭。 在插头（34）从接合部分（31c）脱离之后，在内层袋（22）的内部和过滤器（33）之间建立液体连通。
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公开(公告)号：US08207119B2
公开(公告)日：2012-06-26
申请号：US12559704
申请日：2009-09-15
申请人： Teruo Nishida , Yorihisa Uetake , Hiroaki Iwata
发明人： Teruo Nishida , Yorihisa Uetake , Hiroaki Iwata
IPC分类号： A61K38/00 , A61K43/00 , C07K14/705
CPC分类号： C07K14/78 , A61K9/0048 , A61K38/08
摘要： An object is to find the minimum activity expression site of fibronectin, clarify the actions of this minimum unit in relation to opthalmological fields, and provide an opthalmological composition having this minimum unit as an effective component. This invention provides an opthalmological composition, in particular, a corneal disorder treatment agent containing the peptide, PHSRN (SEQ ID NO: 1) (Pro-His-Ser-Arg-Asn (SEQ ID NO: 1)), or Ac-Pro-His-Ser-Arg-Asn-NH2, which is a derivative thereof, or a salt thereof that is allowable as a medical drug as an effective component. The preferred dosage form is an ophthalmic formulation.
摘要翻译： 目的是找到纤维连接蛋白的最小活性表达位点，阐明该最小单位与眼科学领域相关的作用，并提供具有该最小单位作为有效成分的眼科学成分。 本发明提供一种眼科学组合物，特别是含有肽PHSRN（SEQ ID NO：1）（Pro-His-Ser-Arg-Asn（SEQ ID NO：1））或Ac-Pro的角膜病症治疗剂 作为其衍生物的-His-Ser-Arg-Asn-NH 2或其作为医药用作有效成分的盐。 优选的剂型是眼用制剂。
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公开(公告)号：US20100099629A1
公开(公告)日：2010-04-22
申请号：US12559704
申请日：2009-09-15
申请人： Teruo NISHIDA , Yorihisa Uetake , Hiroaki Iwata
发明人： Teruo NISHIDA , Yorihisa Uetake , Hiroaki Iwata
CPC分类号： C07K14/78 , A61K9/0048 , A61K38/08
摘要： An object is to find the minimum activity expression site of fibronectin, clarify the actions of this minimum unit in relation to opthalmological fields, and provide an opthalmological composition having this minimum unit as an effective component. This invention provides an opthalmological composition, in particular, a corneal disorder treatment agent containing the peptide, PHSRN (SEQ ID NO: 1) (Pro-His-Ser-Arg-Asn (SEQ ID NO: 1)), or Ac-Pro-His-Ser-Arg-Asn-NH2, which is a derivative thereof, or a salt thereof that is allowable as a medical drug as an effective component. The preferred dosage form is an ophthalmic formulation.
摘要翻译： 目的是找到纤维连接蛋白的最小活性表达位点，阐明该最小单位与眼科学领域相关的作用，并提供具有该最小单位作为有效成分的眼科学成分。 本发明提供一种眼科学组合物，特别是含有肽PHSRN（SEQ ID NO：1）（Pro-His-Ser-Arg-Asn（SEQ ID NO：1））或Ac-Pro的角膜病症治疗剂 作为其衍生物的-His-Ser-Arg-Asn-NH 2或其作为医药用作有效成分的盐。 优选的剂型是眼用制剂。
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公开(公告)号：US20070090044A1
公开(公告)日：2007-04-26
申请号：US10578916
申请日：2004-09-17
IPC分类号： B01D24/00
CPC分类号： B65D83/0055 , A61F9/0008 , A61J1/145 , A61J1/1456 , A61J1/1468 , B65D47/18
摘要： This invention provides a filter-equipped container which, particularly in a small-sized eyedrop bottle or the like, is capable of accurate dropping while preventing bubbles from being involved when a contents liquid is to be delivered through a delivery port. To solve such problem, a plug body 12 disposed in the mouth of a bottle 10 is provided with a delivery passage for delivering contents liquid received in the bottle 10, the delivery passage being provided with a filter 25. The filter 25 is composed of a filter film 25a for filtering bacteria to prevent the latter from permeating from upstream to downstream as seen in the direction of delivery, and a contents liquid holding member 25b of porous material disposed upstream of the filter film 25a, the contents liquid holding member 25b being in planar contact with the filter film 25a.
摘要翻译： 本发明提供了一种装有过滤器的容器，特别是在小尺寸的眼药瓶等中，能够在通过输送口输送内容液体的同时防止气泡受到干扰。 为了解决这样的问题，设置在瓶子10的口部的塞体12设置有用于输送容纳在瓶子10内的液体的输送通道，输送通道设有过滤器25。 过滤器25由用于过滤细菌的过滤膜25a，以防止其从输送方向看上游到下游，以及设置在过滤膜25上游的多孔材料的内容物保持部件25b a，内容物液体保持构件25b与过滤膜25a平面接触。
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9.发明授权Discharging container with a filter and a bottle stopper for use in the container 有权带过滤器的放电容器和用于容器的瓶塞公开(公告)号：US06708850B2
公开(公告)日：2004-03-23
申请号：US10111793
申请日：2002-04-26
IPC分类号： B67D558
CPC分类号： B65D83/0055 , A61F9/0008 , A61J1/145 , A61J1/1468 , B65D47/2018 , B65D51/1616
摘要： The present invention provides a discharging container whose main part is a squeeze-bottle adapted for use as eyedroppers and transparent to such a degree as required. This container has to perfectly shut off ambient air and bacteria not to flowing into a liquid content of the container so as to keep it sterilized even after unsealed for use. The discharging container has a laminated bottle 2, and a stopper 3 attached to a finish 2a of the laminated bottle, the bottle being composed of an outer layer 21 and an inner layer 22 delaminating from the outer layer 21. A vent hole 4 is formed in the outer layer so as to introduce ambient air in between the outer and inner layers 21, 22. A discharging passage 10 is formed in the stopper 3 so as to exude through it a liquid content inside the inner layer 22, and the stopper further has a check valve 8 and a filter 7 disposed on the downstream side of the valve.
摘要翻译： 本发明提供了一种排出容器，其主要部分是适于用作吸管的挤压瓶，并且在所需的程度上是透明的。 该容器必须完全切断环境空气和细菌不会流入容器的液体内容物中，以便即使在使用后也可将其灭菌。排放容器具有层压瓶2和塞子3， 该瓶子由外层21和从外层21分层的内层22组成。在外层中形成有通气孔4，以将环境空气引入外层和内层之间 在止动件3中形成排出通道10，以便在其内部含有液体内容物22，并且止动器还具有设置在阀门下游侧的止回阀8和过滤器7 。
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公开(公告)号：US08490839B2
公开(公告)日：2013-07-23
申请号：US12995736
申请日：2009-05-21
申请人： Hirokazu Mihashi , Seiji Yoshimura , Kazuko Suzuki , Yorihisa Uetake , Norio Hoshi , Shinji Matsuda , Hidetoshi Kondo
发明人： Hirokazu Mihashi , Seiji Yoshimura , Kazuko Suzuki , Yorihisa Uetake , Norio Hoshi , Shinji Matsuda , Hidetoshi Kondo
IPC分类号： B67D7/76
CPC分类号： B65D47/2031 , A61F9/0008 , B65D47/18 , B65D51/1616
摘要： In a filtering dispenser container which includes a plug attached to a mouth portion of a bottle thereof and having a liquid discharge passage, and a filter and a check valve provided in the discharge passage, air lock is prevented, even if the container contains a highly percolative liquid, by preventing a very small amount of liquid percolating the check valve from reaching the filter. In the filtering dispenser container, a dam (14) is provided between the check valve (23) and the filter (25) for retaining a very small amount of the liquid percolating the check valve (23) when the check valve is closed. Thus, the filter (25) is prevented from being wetted with the liquid percolating the closed check valve (23) during storage or delivery of the container before the first use of the container.
摘要翻译： 在一个过滤分配器容器中，包括一个附着在其瓶口部分上并具有一个液体排放通道的塞子，以及设置在该排出通道中的一个过滤器和一个止回阀，即使该容器含有高度的空气， 渗透液体，通过防止非常少量的液体渗透止回阀到达过滤器。 在过滤分配器容器中，在止回阀（23）和过滤器（25）之间设有一个挡块（14），用于在止回阀关闭时保持非常少量渗透止回阀（23）的液体。 因此，在第一次使用容器之前，在容器的储存或运送过程中，防止过滤器（25）被液体渗透到封闭的止回阀（23）上。
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