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公开(公告)号：US08258264B2
公开(公告)日：2012-09-04
申请号：US10552369
申请日：2004-04-08
CPC分类号： C07K14/76 , A61K38/38 , B01D61/147
摘要： An albumin preparation may be produced efficiently on a commercial basis that has reduced possibility of contamination of infectious viruses and has high safety and stability. The process according to the present invention comprises a step of filtration of a serum albumin-containing solution with a virus-removing membrane preferably with a pore size of 10 to 20 nm. In particular, said filtration is performed before heat treatment for inactivation of viruses. In a more preferable embodiment, said serum albumin-containing solution is treated with an anion exchanger and/or a prefilter before a step of said filtration.
摘要翻译： 可以商业上有效地生产白蛋白制剂，其具有降低的感染性病毒污染的可能性并且具有高的安全性和稳定性。 根据本发明的方法包括用优选具有10至20nm的孔径的病毒除去膜过滤含血清白蛋白的溶液的步骤。 特别地，所述过滤在用于灭活病毒的热处理之前进行。 在更优选的实施方案中，所述含血清白蛋白的溶液在所述过滤步骤之前用阴离子交换剂和/或预过滤器处理。
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公开(公告)号：US20060281903A1
公开(公告)日：2006-12-14
申请号：US10552369
申请日：2004-04-08
IPC分类号： C07K14/765
CPC分类号： C07K14/76 , A61K38/38 , B01D61/147
摘要： An albumin preparation may be produced efficiently on a commercial basis that has reduced possibility of contamination of infectious viruses and has high safety and stability. The process according to the present invention comprises a step of filtration of a serum albumin-containing solution with a virus-removing membrane preferably with a pore size of 10 to 20 nm. In particular, said filtration is performed before heat treatment for inactivation of viruses. In a more preferable embodiment, said serum albumin-containing solution is treated with an anion exchanger and/or a prefilter before a step of said filtration.
摘要翻译： 可以商业上有效地生产白蛋白制剂，其具有降低的感染性病毒污染的可能性并且具有高的安全性和稳定性。 根据本发明的方法包括用优选具有10至20nm的孔径的病毒除去膜过滤含血清白蛋白的溶液的步骤。 特别地，所述过滤在用于灭活病毒的热处理之前进行。 在更优选的实施方案中，所述含血清白蛋白的溶液在所述过滤步骤之前用阴离子交换剂和/或预过滤器处理。
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