公开(公告)号：US20070218123A1

公开(公告)日：2007-09-20

申请号：US11708932

申请日：2007-02-20

申请人： Dennis Discher ,  Bohdana Discher ,  You-Yeon Won ,  James C-M Lee ,  Daniel Hammer ,  Frank Bates

发明人： Dennis Discher ,  Bohdana Discher ,  You-Yeon Won ,  James C-M Lee ,  Daniel Hammer ,  Frank Bates

IPC分类号： A61K9/127 ,  C12N1/00

CPC分类号： A61K9/1273 ,  Y10T428/2984

摘要： The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.

公开(公告)号：US07867512B2

公开(公告)日：2011-01-11

申请号：US11708932

申请日：2007-02-20

申请人： Dennis E. Discher ,  Bohdana M. Discher ,  You-Yeon Won ,  James C-M Lee ,  Daniel A. Hammer ,  Frank Bates

发明人： Dennis E. Discher ,  Bohdana M. Discher ,  You-Yeon Won ,  James C-M Lee ,  Daniel A. Hammer ,  Frank Bates

IPC分类号： A61K9/127

CPC分类号： A61K9/1273 ,  Y10T428/2984

摘要： The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.

摘要翻译： 本发明提供包含形成在水溶液中并且包含一种或多种合成的超亲水性分子的半透性薄壁包封膜的生物相容性囊泡。 当至少一个超两亲分子是嵌段共聚物时，所得的合成泡囊称为“聚合物聚合物”。两亲性组合物的合成，反应性质能够在保持半渗透性的同时进行膜的广泛共价交联。 聚合物构建块组分的交联为泡囊提供机械控制和长期稳定性，从而也提供了通过改变膜的组成来控制从泡囊包裹或释放材料的方法。 因此，本发明的封装膜特别适用于材料的可靠，耐用和受控的运输，输送和储存。

公开(公告)号：US07217427B2

公开(公告)日：2007-05-15

申请号：US10882816

申请日：2004-07-01

申请人： Dennis E. Discher ,  Bohdana M. Discher ,  You-Yeon Won ,  James C-M Lee ,  Daniel A. Hammer ,  Frank Bates

发明人： Dennis E. Discher ,  Bohdana M. Discher ,  You-Yeon Won ,  James C-M Lee ,  Daniel A. Hammer ,  Frank Bates

IPC分类号： A61K9/127

CPC分类号： A61K9/1273 ,  Y10T428/2984

摘要： The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.

摘要翻译： 本发明提供包含形成在水溶液中并且包含一种或多种合成的超亲水性分子的半透性薄壁包封膜的生物相容性囊泡。 当至少一个超两亲分子是嵌段共聚物时，所得的合成泡囊称为“聚合物体”。 两亲性组合物的合成，反应性质能够在保持半渗透性的同时进行膜的广泛共价交联。 聚合物构建块组分的交联为泡囊提供机械控制和长期稳定性，从而也提供了通过改变膜的组成来控制从泡囊包裹或释放材料的方法。 因此，本发明的封装膜特别适用于材料的可靠，耐用和受控的运输，输送和储存。

公开(公告)号：US20050048110A1

公开(公告)日：2005-03-03

申请号：US10882816

申请日：2004-07-01

申请人： Dennis Discher ,  Bohdana Discher ,  You-Yeon Won ,  James Lee ,  Daniel Hammer ,  Frank Bates

发明人： Dennis Discher ,  Bohdana Discher ,  You-Yeon Won ,  James Lee ,  Daniel Hammer ,  Frank Bates

IPC分类号： A61K9/127 ,  A61K9/14

CPC分类号： A61K9/1273 ,  Y10T428/2984

摘要： The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.

摘要翻译： 本发明提供包含形成在水溶液中并且包含一种或多种合成的超亲水性分子的半渗透薄壁包封膜的生物相容性囊泡。 当至少一个超两亲分子是嵌段共聚物时，所得的合成泡囊称为“聚合物体”。 两亲性组合物的合成，反应性质能够在保持半渗透性的同时进行膜的广泛共价交联。 聚合物构建块组分的交联为泡囊提供机械控制和长期稳定性，从而也提供了通过改变膜的组成来控制从泡囊包裹或释放材料的方法。 因此，本发明的封装膜特别适用于材料的可靠，耐用和受控的运输，输送和储存。

公开(公告)号：US06835394B1

公开(公告)日：2004-12-28

申请号：US09460605

申请日：1999-12-14

申请人： Dennis E. Discher ,  Bohdana M. Discher ,  You-Yeon Won ,  James C-M. Lee ,  Frank S. Bates ,  Daniel A. Hammer

发明人： Dennis E. Discher ,  Bohdana M. Discher ,  You-Yeon Won ,  James C-M. Lee ,  Frank S. Bates ,  Daniel A. Hammer

IPC分类号： A61K9127

CPC分类号： A61K9/1273 ,  Y10T428/2984

摘要： The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.

摘要翻译： 本发明提供包含形成在水溶液中并且包含一种或多种合成的超亲水性分子的半透性薄壁包封膜的生物相容性囊泡。 当至少一个超两亲分子是嵌段共聚物时，所得的合成泡囊称为“聚合物体”。 两亲性组合物的合成，反应性质能够在保持半渗透性的同时进行膜的广泛共价交联。 聚合物构建块组分的交联为泡囊提供机械控制和长期稳定性，从而也提供了通过改变膜的组成来控制从泡囊包裹或释放材料的方法。 因此，本发明的封装膜特别适用于材料的可靠，耐用和受控的运输，输送和储存。