公开(公告)号：US08754058B2

公开(公告)日：2014-06-17

申请号：US13498717

申请日：2010-11-26

申请人： Youfei Guan ,  Zicai Liang

发明人： Youfei Guan ,  Zicai Liang

IPC分类号： C12N15/11 ,  C12Q1/68

CPC分类号： C12N15/1136 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  A61K2039/505 ,  C07K16/18 ,  C12N2310/14 ,  C12N2310/31 ,  C12N2310/321

摘要： Inhibitors that can inhibit expression of FAM3B gene to reduce the levels of expression products, or can combine the expression products to reduce the activity of promoting lipid synthesis of FAM3B gene product are provided, wherein the inhibitors are one or more inhibitors selected from the group consisting of small interfering RNAs, antisense oligonucleotides, antibodies against FAM3B proteins and active organic compounds. Cells, vectors or inhibitor compositions, comprising such inhibitors, methods for inhibiting expression of FAM3B gene or inhibiting the activity of promoting lipid synthesis of FAM3B gene product using the inhibitors are provided. Methods for treating diseases mediated by expression of FAM3B gene using such inhibitors and uses of the inhibitors in preparing pharmaceuticals for preventing and/or treating the disease mediated by FAM3B gene expression are also provided.

摘要翻译： 提供可以抑制FAM3B基因表达以降低表达产物水平的抑制剂，或可以组合表达产物以降低促进FAM3B基因产物的脂质合成的活性，其中所述抑制剂是一种或多种选自以下的抑制剂： 小干扰RNA，反义寡核苷酸，抗FAM3B蛋白和活性有机化合物的抗体。 提供了包含这些抑制剂的细胞，载体或抑制剂组合物，使用抑制剂抑制FAM3B基因表达或抑制促进FAM3B基因产物的脂质合成活性的方法。 还提供了使用这种抑制剂治疗由FAM3B基因表达介导的疾病的方法以及抑制剂在制备用于预防和/或治疗由FAM3B基因表达介导的疾病的药物中的用途。

公开(公告)号：US20130046006A1

公开(公告)日：2013-02-21

申请号：US13498717

申请日：2010-11-26

申请人： Youfei Guan ,  Zicai Liang

发明人： Youfei Guan ,  Zicai Liang

IPC分类号： C07H21/02 ,  A61P3/06 ,  A61P1/16 ,  A61K31/713 ,  C07H1/00

CPC分类号： C12N15/1136 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  A61K2039/505 ,  C07K16/18 ,  C12N2310/14 ,  C12N2310/31 ,  C12N2310/321

摘要： Inhibitors that can inhibit expression of FAM3B gene to reduce the levels of expression products, or can combine the expression products to reduce the activity of promoting lipid synthesis of FAM3B gene product are provided, wherein the inhibitors are one or more inhibitors selected from the group consisting of small interfering RNAs, antisense oligonucleotides, antibodies against FAM3B proteins and active organic compounds. Cells, vectors or inhibitor compositions, comprising such inhibitors, methods for inhibiting expression of FAM3B gene or inhibiting the activity of promoting lipid synthesis of FAM3B gene product using the inhibitors are provided. Methods for treating diseases mediated by expression of FAM3B gene using such inhibitors and uses of the inhibitors in preparing pharmaceuticals for preventing and/or treating the disease mediated by FAM3B gene expression are also provided.

摘要翻译： 提供可以抑制FAM3B基因表达以降低表达产物水平的抑制剂，或可以组合表达产物以降低促进FAM3B基因产物的脂质合成的活性，其中所述抑制剂是一种或多种选自以下的抑制剂： 小干扰RNA，反义寡核苷酸，抗FAM3B蛋白和活性有机化合物的抗体。 提供了包含这些抑制剂的细胞，载体或抑制剂组合物，使用抑制剂抑制FAM3B基因表达或抑制促进FAM3B基因产物的脂质合成活性的方法。 还提供了使用这种抑制剂治疗由FAM3B基因表达介导的疾病的方法以及抑制剂在制备用于预防和/或治疗由FAM3B基因表达介导的疾病的药物中的用途。