公开(公告)号：US20110034871A1

公开(公告)日：2011-02-10

申请号：US12908686

申请日：2010-10-20

申请人： Young Kon Kim ,  Jae Geun Park ,  Sang Guon Lee ,  Woon Sub Baek

发明人： Young Kon Kim ,  Jae Geun Park ,  Sang Guon Lee ,  Woon Sub Baek

IPC分类号： A61F7/00 ,  B05D7/00

CPC分类号： A61K9/0009 ,  A61K9/0024 ,  A61K9/0092

摘要： Disclosed is a thermorod for active drug release capable of actively releasing drugs according to temperature and a method of manufacturing the same. The method for manufacturing a thermorod for active drug release that generates heat by means of eddy current loss and hysteresis loss in an induced magnetic field comprises: processing the thermorod into a certain shape; preparing a mixed-drug specimen by mixing a drug with a high molecular compound acting as a support of the drug; and forming a mixed-drug layer on the surface of the thermorod by using the mixed-drug specimen. Also, the thermorod for active drug release manufactured by the method is provided. Therefore, the method and thermorod prepared by the method may be useful to effectively perform the drug administration and anti-cancer drug treatment of affected parts since they may be used to perform local hyperthermia at 36.5° C. or above and to actively control the active drug release and delivery according to temperature as well. Also, the method and the thermorod prepared by the method may be useful in the treatment of resting tumor cells along with hyperthermia by performing a surgical operation on lesion sites of biological tissues using the thermorod for active drug release, and in minimizing the toxicity caused by an increase in blood drug concentration, which is generated when a drug is administered by a conventional method, since the drug is effectively delivered to an affected part in response to the active drug release.

摘要翻译： 公开了一种能够根据温度积极释放药物的活性药物释放的热电偶及其制造方法。 用于制造用于通过感应磁场中的涡流损耗和滞后损耗产生热量的活性药物释放热点的方法包括：将热电极加工成一定形状; 通过将药物与作为药物载体的高分子化合物混合来制备混合药物标本; 并通过使用混合药物试样在热电偶表面上形成混合药物层。 此外，提供了通过该方法制造的用于活性药物释放的热电偶。 因此，通过该方法制备的方法和热量可以有效地进行受影响部位的药物给药和抗癌药物治疗，因为它们可用于在36.5℃或更高温度下进行局部高热并且主动控制活性物质 根据温度，药物释放和递送。 此外，通过该方法制备的方法和热棒可以用于治疗休息的肿瘤细胞以及热疗，通过使用热活性药物释放的生物组织的病变部位进行外科手术，并且最小化由 药物通过常规方法施用时产生的药物浓度增加，因为药物响应于活性药物释放被有效地递送到患部分。

公开(公告)号：US06567381B1

公开(公告)日：2003-05-20

申请号：US09468094

申请日：1999-12-21

申请人： Young Ki Jeon ,  Young Kon Kim ,  Dae Gun Choi ,  Jae Won Chang ,  Woon Hee Nah

发明人： Young Ki Jeon ,  Young Kon Kim ,  Dae Gun Choi ,  Jae Won Chang ,  Woon Hee Nah

IPC分类号： H04J314

CPC分类号： H04W28/18 ,  H04B1/707 ,  H04B17/16 ,  H04B17/18 ,  H04W24/06 ,  H04W52/0203 ,  H04W60/00 ,  H04W76/10 ,  Y02D70/164 ,  Y02D70/40

摘要： A method automatically measures parameter data relating to wireless network environment in a code division multiple access(CDMA) system. First, if a server's telephone number is detected from power-on registration data stored in a storage device, then a connection with the server is attempted through a mobile station with a data service function using the server's telephone number. Thereafter, if there is test plan program data from the server after the connection is made, the parameter data is measured using another mobile station with a diagnostic monitor function based on the test plan program data. The measured parameter data is then collected and parsed to obtain sets of measured parameter data, each set having a different kind of measured data; and, finally, the sets of measured parameter data are transmitted to the server using the mobile station with the data service function when there is a data transmission request from the server.

摘要翻译： 一种方法在码分多址（CDMA）系统中自动测量与无线网络环境有关的参数数据。 首先，如果从存储设备中存储的上电注册数据检测到服务器的电话号码，则通过使用服务器的电话号码的数据服务功能的移动台尝试与服务器的连接。 此后，如果在连接之后存在来自服务器的测试计划程序数据，则使用具有基于测试计划程序数据的诊断监视功能的另一个移动站来测量参数数据。 然后收集测量的参数数据并进行解析以获得测量参数数据集，每组具有不同种类的测量数据; 并且最后，当存在来自服务器的数据传输请求时，使用具有数据服务功能的移动台将所测量的参数数据集发送到服务器。

公开(公告)号：US08906391B2

公开(公告)日：2014-12-09

申请号：US12908686

申请日：2010-10-20

申请人： Young Kon Kim ,  Jae Geun Park ,  Sang Guon Lee ,  Woon Sub Baek

发明人： Young Kon Kim ,  Jae Geun Park ,  Sang Guon Lee ,  Woon Sub Baek

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61F7/12

CPC分类号： A61K9/0009 ,  A61K9/0024 ,  A61K9/0092

摘要： Disclosed is a thermorod capable of actively releasing drugs according to temperature of the thermorod and a method of manufacturing the same. The thermorod generates heat by eddy current loss and hysteresis loss in an induced magnetic field. The thermorods can effectively administer drugs, such as anti-cancer drugs, since the thermorods may be used to perform local hyperthermia at 36.5° C. or above and to actively control the active drug release and delivery according to temperature as well. The thermorods may be useful in the treatment of resting tumor cells along with hyperthermia by performing a surgical operation on lesion sites of biological tissues. Using the thermorod, the drug is effectively delivered to an affected part in response to the active drug release. This can minimize the toxicity caused by an increase in blood drug concentration, which occurs when a drug is administered by a conventional method.

摘要翻译： 公开了能够根据热电偶的温度积极释放药物的热电极及其制造方法。 热电偶通过感应磁场中的涡流损耗和滞后损耗产生热量。 Thermorods可以有效地服用药物，如抗癌药物，因为热电极可以用于在36.5°C或更高温度下进行局部热疗，并根据温度主动控制活性药物的释放和输送。 通过对生物组织的病变部位进行外科手术，热棒可用于治疗休息的肿瘤细胞以及热疗。 使用thermorod，药物有效地传递到受影响的部分响应活跃的药物释放。 这可以最小化由药物通过常规方法施用时发生的血药浓度增加引起的毒性。