公开(公告)号：US08940303B2

公开(公告)日：2015-01-27

申请号：US13013993

申请日：2011-01-26

Applicant: Ian Kirby ,  Alex H. Taylor ,  Thomas Matthew Webb ,  Yu Xue

Inventor： Ian Kirby ,  Alex H. Taylor ,  Thomas Matthew Webb ,  Yu Xue

IPC: A61K39/395 ,  A61K38/20 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antigen binding proteins which bind to human IL-7 receptor (CD127) are provided. The antigen binding proteins are typically antibodies, and are useful in the treatment of diseases or disorders in humans, particularly autoimmune diseases such as multiple sclerosis.

公开(公告)号：US20120282254A1

公开(公告)日：2012-11-08

申请号：US13574847

申请日：2011-01-26

Applicant: Ian Kirby ,  Alexander H. Taylor ,  Thomas Matthew Webb ,  Yu Xue

Inventor： Ian Kirby ,  Alexander H. Taylor ,  Thomas Matthew Webb ,  Yu Xue

IPC: C07K16/46 ,  C12N15/63 ,  C12P21/08 ,  A61K39/395 ,  C07K16/28 ,  C12N5/10 ,  A61P37/06 ,  A61P29/00 ,  C12N1/21 ,  C12N1/19 ,  C12N1/15 ,  C12N15/62 ,  A61P25/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antigen binding proteins which bind to human IL-7 receptor (CD127) are provided. The antigen binding proteins are typically antibodies, and are useful in the treatment of diseases or disorders in humans, particularly autoimmune diseases such as multiple sclerosis.

Abstract translation: 提供了结合人IL-7受体（CD127）的抗原结合蛋白。 抗原结合蛋白通常是抗体，并且可用于治疗人类的疾病或病症，特别是自身免疫性疾病如多发性硬化症。

公开(公告)号：US20110200585A1

公开(公告)日：2011-08-18

申请号：US13013993

申请日：2011-01-26

Applicant: IAN KIRBY ,  ALEX H. TAYLOR ,  THOMAS MATTHEW WEBB ,  YU XUE

Inventor： IAN KIRBY ,  ALEX H. TAYLOR ,  THOMAS MATTHEW WEBB ,  YU XUE

IPC: A61K39/395 ,  C07K16/00 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  A61P37/06 ,  A61P29/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antigen binding proteins which bind to human IL-7 receptor (CD127) are provided. The antigen binding proteins are typically antibodies, and are useful in the treatment of diseases or disorders in humans, particularly autoimmune diseases such as multiple sclerosis.

Abstract translation: 提供结合人IL-7受体（CD127）的抗原结合蛋白。 抗原结合蛋白通常是抗体，并且可用于治疗人类的疾病或病症，特别是自身免疫性疾病如多发性硬化症。

公开(公告)号：US09150653B2

公开(公告)日：2015-10-06

申请号：US13574847

申请日：2011-01-26

Applicant: Ian Kirby ,  Alexander H. Taylor ,  Thomas Matthew Webb ,  Yu Xue

Inventor： Ian Kirby ,  Alexander H. Taylor ,  Thomas Matthew Webb ,  Yu Xue

IPC: C07K16/46 ,  A61K39/395 ,  C07K16/28 ,  A61P37/06 ,  C12N1/15 ,  C12N15/62 ,  C12P21/08 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antigen binding proteins which bind to human IL-7 receptor (CD127) are provided. The antigen binding proteins are typically antibodies, and are useful in the treatment of diseases or disorders in humans, particularly autoimmune diseases such as multiple sclerosis.

Abstract translation: 提供了结合人IL-7受体（CD127）的抗原结合蛋白。 抗原结合蛋白通常是抗体，并且可用于治疗人类的疾病或病症，特别是自身免疫性疾病如多发性硬化症。

公开(公告)号：US20130156779A1

公开(公告)日：2013-06-20

申请号：US13639918

申请日：2011-09-02

Applicant: Neil James Clarke ,  Kyung Oh Johanson ,  Zdenka Ludmila Jonak ,  Alexander H. Taylor ,  Christopher B. Hopson ,  Stephen H. Trulli ,  Zdenka Haskova ,  Judithann M. Lee ,  John R. White ,  Yu Xue

Inventor： Neil James Clarke ,  Kyung Oh Johanson ,  Zdenka Ludmila Jonak ,  Alexander H. Taylor ,  Christopher B. Hopson ,  Stephen H. Trulli ,  Zdenka Haskova ,  Judithann M. Lee ,  John R. White ,  Yu Xue

IPC: C07K16/28

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.

Abstract translation: 本公开涉及结合HER3的抗原结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物及其制备方法。 本公开还涉及这种抗原结合蛋白在治疗或预防与乳腺癌，卵巢癌，前列腺癌，膀胱癌，胰腺，胃癌，黑素瘤和其它过表达HER3的癌症相关的疾病中的用途。

公开(公告)号：US20070027332A1

公开(公告)日：2007-02-01

申请号：US11377939

申请日：2006-03-16

Applicant: Ragina Naidu ,  Samuel Foo ,  Bao Yu Xue ,  Bo Fan

Inventor： Ragina Naidu ,  Samuel Foo ,  Bao Yu Xue ,  Bo Fan

IPC: C07D305/12

CPC classification number: C07D305/14

Abstract: A process is provided for the semi-synthesis of taxane derivatives useful in the preparation of docetaxel, in particular, the semi-synthesis of protected taxane derivatives in a one pot reaction of protecting the C-2′, C-7 and C-10 and introducing a t-Boc group at the nitrogen of the amide group at the C-3′ position in paclitaxel and subsequently conversion to docetaxel, and derivatives used therein.

Abstract translation: 提供了一种用于制备多西他赛的紫杉烷衍生物的半合成方法，特别是在保护C-2'，C-7和C-10的一锅反应中保护的紫杉烷衍生物的半合成 并在紫杉醇的C-3'位置的酰胺基的氮上引入t-Boc基团，随后转化为多西紫杉醇及其中所用的衍生物。

公开(公告)号：US09085622B2

公开(公告)日：2015-07-21

申请号：US13639918

申请日：2011-09-02

Applicant: Neil James Clarke ,  Kyung Oh Johanson ,  Zdenka Ludmila Jonak ,  Alexander H. Taylor ,  Christopher B. Hopson ,  Stephen H. Trulli ,  Zdenka Haskova ,  Judithann M. Lee ,  John R. White ,  Yu Xue

Inventor： Neil James Clarke ,  Kyung Oh Johanson ,  Zdenka Ludmila Jonak ,  Alexander H. Taylor ,  Christopher B. Hopson ,  Stephen H. Trulli ,  Zdenka Haskova ,  Judithann M. Lee ,  John R. White ,  Yu Xue

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/32 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.

Abstract translation: 本公开涉及结合HER3的抗原结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物和制备方法。 本公开还涉及这种抗原结合蛋白在治疗或预防与乳腺癌，卵巢癌，前列腺癌，膀胱癌，胰腺，胃癌，黑素瘤和其它过表达HER3的癌症相关的疾病中的用途。