公开(公告)号：US20060183886A1

公开(公告)日：2006-08-17

申请号：US11256476

申请日：2005-10-21

申请人： Paul Tso ,  Robert Duff ,  Yuanzhong Zhou ,  Scott Deamond ,  Clinton Roby

发明人： Paul Tso ,  Robert Duff ,  Yuanzhong Zhou ,  Scott Deamond ,  Clinton Roby

IPC分类号： C07K14/005 ,  C07K16/10

CPC分类号： C07H15/18 ,  A61K47/549 ,  A61K47/6425 ,  A61K47/65 ,  C07H21/00

摘要： The present invention relates to the design and synthesis of homogeneous A-L-P constructs, which contain a hepatic ligand to direct an oligomer or “payload” to a hepatocyte intracellularly via a receptor-mediated, ligand-directed pathway.