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公开(公告)号：US11497754B2
公开(公告)日：2022-11-15
申请号：US16782406
申请日：2020-02-05
摘要： The present disclosure is directed to a composition for prevention or treatment of neurodegenerative conditions. The composition comprises a neurosteroid, a synthetic enantiomer of a neurosteroid, or a combination thereof.
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2.发明申请公开(公告)号：US20200246356A1
公开(公告)日：2020-08-06
申请号：US16782406
申请日：2020-02-05
摘要： The present disclosure is directed to a composition for prevention or treatment of neurodegenerative conditions. The composition comprises a neurosteroid, a synthetic enantiomer of a neurosteroid, or a combination thereof.
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3.发明授权
公开(公告)号：US5395822A
公开(公告)日：1995-03-07
申请号：US124348
申请日：1993-09-20
申请人： Yukitoshi Izumi , John W. Olney
发明人： Yukitoshi Izumi , John W. Olney
摘要： This invention discloses a method of using a salt of pyruvic acid (such as sodium pyruvate) to protect against neuronal degeneration due to ischemia (inadequate blood flow, which can be caused by stroke, cardiac arrest, or other events) or due to hypoxia, hypoglycemia, or cellular disorders which interfere with the energy metabolism of neurons. Treatment with pyruvate can be effective even when administered after the onset of an event that triggers neurodegeneration. A preferred mode of use involves co-administration of a pyruvate salt along with one or more agents that block NMDA and/or non-NMDA receptors, or with insulin or a thrombolytic agent.
摘要翻译： 本发明公开了一种使用丙酮酸盐（如丙酮酸钠）的方法，用于防止缺血（由中风，心脏骤停或其他事件引起的血流不足）或由于缺氧引起的神经元变性， 低血糖或干扰神经元能量代谢的细胞紊乱。 即使在触发神经变性的事件开始后给予丙酮酸治疗也是有效的。 优选的使用方式包括丙酮酸盐与一种或多种阻断NMDA和/或非NMDA受体或与胰岛素或血栓溶解剂的药剂共同给药。
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