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    NEUROACTIVE 17(20)-Z-VINYLCYANO-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME
    5.
    发明申请
    NEUROACTIVE 17(20)-Z-VINYLCYANO-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME 有权
    神经元17（20）-Z-乙烯基取代的甾族化合物，其制剂及其使用方法

    公开(公告)号：US20140309443A1

    公开(公告)日：2014-10-16

    申请号：US14000519

    申请日：2012-02-24

    申请人： Douglas Covey ,  Eva Kudcva

    发明人： Douglas Covey ,  Eva Kudcva

    IPC分类号： C07J41/00

    CPC分类号： C07J41/0094 ,  C07J1/0011 ,  C07J3/00 ,  C07J7/002 ,  C07J13/005 ,  C07J21/008

    摘要： The present disclosure is generally directed to neuroactive 17(20)-Z-vinylcyano-substituted compound of Formula (I) and (II), as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.

    摘要翻译： 本公开一般涉及本文所提及的式（I）和（II）的神经活性的17（20）-Z-乙烯基氰取代的化合物及其药学上可接受的盐，用作例如麻醉剂，和 /或治疗与GABA功能和活动相关的疾病。 本公开进一步涉及包含这些化合物的药物组合物。

    MODIFIED, HYDROXY-SUBSTITUTED AROMATIC STRUCTURES HAVING CYTOPROTECTIVE ACTIVITY
    6.
    发明申请
    MODIFIED, HYDROXY-SUBSTITUTED AROMATIC STRUCTURES HAVING CYTOPROTECTIVE ACTIVITY 审中-公开
    改性，羟基取代的具有抗肿瘤活性的芳香结构

    公开(公告)号：US20060009438A2

    公开(公告)日：2006-01-12

    申请号：US10971423

    申请日：2004-10-22

    申请人： Douglas Covey

    发明人： Douglas Covey

    IPC分类号： A61K31/56

    CPC分类号： C07J1/00 ,  A61K31/565 ,  C07J1/0059 ,  C07J1/007

    摘要： Abstract of the DisclosureThe present invention is directed to a process for conferring cytoprotection on a population of cells which comprises administering to that population of cells a compound comprising a hydroxy-substituted aromatic ring structure and a non-fused polycyclic, hydrophobic substituent attached thereto. In particular, the present invention is directed to such a process wherein the administered compound is phenolic, such as a steriod (e.g., estrogen), and has a non-fused polycyclic, hydrophobic substituent attached to the hydroxy-substituted A-ring thereof.

    摘要翻译： 发明内容本发明涉及一种赋予细胞群的细胞保护作用的方法，该方法包括对所述细胞群施用包含羟基取代的芳环结构和与其连接的非稠合多环疏水性取代基的化合物。 特别地，本发明涉及这样的方法，其中所施用的化合物是酚类，例如steriod（例如雌激素），并且具有与其羟基取代的A环连接的非稠合的多环疏水性取代基。