公开(公告)号：US07537803B2

公开(公告)日：2009-05-26

申请号：US10820091

申请日：2004-04-07

申请人： Yulu Wang ,  Robert Pfeffer ,  Rajesh Dave

发明人： Yulu Wang ,  Robert Pfeffer ,  Rajesh Dave

IPC分类号： B05D7/00 ,  C08J7/16 ,  B01J19/10 ,  B29B9/08

CPC分类号： A61K9/5153 ,  A61K9/5031 ,  A61K9/5089 ,  A61K9/5192 ,  B01J2/006 ,  C08J3/212 ,  C08K9/08 ,  C09D7/40 ,  C09D11/52 ,  Y02P20/544 ,  Y10T428/25 ,  Y10T428/2998

摘要： A process, method and/or system for preparing polymer-coated nanoparticles and/or other ultrafine particles utilizing a supercritical fluid, e.g., supercritical carbon dioxide (SC CO2), as an antisolvent that may be added to a solution of a polymer and an organic solvent in which insoluble nanoparticles or the like are suspended. The coating process occurs when the supercritical fluid (e.g., SC CO2) and the nanoparticle-containing suspension are combined to cause the suspended nanoparticles to precipitate as coated nanoparticles. Processing parameters for optimizing and/or enhancing the efficacy and/or efficiency of the coating process, method and/or system and for controlling the coating and/or agglomeration of coated particles are also described. The process, method and/or system has wide ranging applicability, e.g., for coating and/or encapsulation of pharmaceuticals, cosmetics, food products, chemicals, agrochemicals, pesticides, polymers, coatings, catalysts and the like.

摘要翻译： 使用超临界流体（例如超临界二氧化碳（SCCO 2））制备聚合物涂覆的纳米颗粒和/或其它超微粒子的方法，方法和/或系统作为可以加入到聚合物溶液中的抗溶剂 其中悬浮有不溶性纳米颗粒等的有机溶剂。 当超临界流体（例如SCCO 2）和含纳米颗粒的悬浮液组合以引起悬浮的纳米颗粒作为包覆的纳米颗粒沉淀时，发生涂覆过程。 还描述了用于优化和/或增强涂覆工艺，方法和/或系统的功效和/或效率以及用于控制涂覆颗粒的涂覆和/或附聚的加工参数。 方法，方法和/或系统具有广泛的适用性，例如用于药物，化妆品，食品，化学品，农业化学品，农药，聚合物，涂料，催化剂等的涂覆和/或包封。

公开(公告)号：US11065265B2

公开(公告)日：2021-07-20

申请号：US16245992

申请日：2019-01-11

申请人： Jianwei Yu ,  Yulu Wang

发明人： Jianwei Yu ,  Yulu Wang

IPC分类号： A61K31/675 ,  A61K47/40 ,  A61K9/08 ,  A61K9/00 ,  A61K47/18

摘要： The present application and its embodiments teach stable compositions of fosaprepitant or a pharmaceutically acceptable salt thereof with such compositions lacking polysorbate 80 and containing dual functional excipients of hydrolysis inhibition and solubility enhancement. Further described are methods of preparation of such compositions. Among other advantages of contemplated compositions, fosaprepitant hydrolysis degradation is kept low and the compositions maintain physically and chemically stable for prolonged period.

公开(公告)号：US20190350947A1

公开(公告)日：2019-11-21

申请号：US16245992

申请日：2019-01-11

申请人： Jianwei Yu ,  Yulu Wang ,  Qihai Tao

发明人： Jianwei Yu ,  Yulu Wang ,  Qihai Tao

IPC分类号： A61K31/675 ,  A61K47/40 ,  A61K47/18 ,  A61K9/00 ,  A61K9/08

摘要： The present application and its embodiments teach stable compositions of fosaprepitant or a pharmaceutically acceptable salt thereof with such compositions lacking polysorbate 80 and containing dual functional excipients of hydrolysis inhibition and solubility enhancement. Further described are methods of preparation of such compositions. Among other advantages of contemplated compositions, fosaprepitant hydrolysis degradation is kept low and the compositions maintain physically and chemically stable for prolonged period.

公开(公告)号：US20050191491A1

公开(公告)日：2005-09-01

申请号：US10820091

申请日：2004-04-07

申请人： Yulu Wang ,  Robert Pfeffer ,  Rajesh Dave

发明人： Yulu Wang ,  Robert Pfeffer ,  Rajesh Dave

IPC分类号： A61K9/50 ,  A61K9/51 ,  B01J2/00 ,  B05D3/00 ,  B32B5/16 ,  B32B9/00 ,  C08J3/21 ,  C09D7/12 ,  C09D11/00

CPC分类号： A61K9/5153 ,  A61K9/5031 ,  A61K9/5089 ,  A61K9/5192 ,  B01J2/006 ,  C08J3/212 ,  C08K9/08 ,  C09D7/40 ,  C09D11/52 ,  Y02P20/544 ,  Y10T428/25 ,  Y10T428/2998

摘要： A process, method and/or system for preparing polymer-coated nanoparticles and/or other ultrafine particles utilizing a supercritical fluid, e.g., supercritical carbon dioxide (SC CO2), as an antisolvent that may be added to a solution of a polymer and an organic solvent in which insoluble nanoparticles or the like are suspended. The coating process occurs when the supercritical fluid (e.g., SC CO2) and the nanoparticle-containing suspension are combined to cause the suspended nanoparticles to precipitate as coated nanoparticles. Processing parameters for optimizing and/or enhancing the efficacy and/or efficiency of the coating process, method and/or system and for controlling the coating and/or agglomeration of coated particles are also described. The process, method and/or system has wide ranging applicability, e.g., for coating and/or encapsulation of pharmaceuticals, cosmetics, food products, chemicals, agrochemicals, pesticides, polymers, coatings, catalysts and the like.

摘要翻译： 使用超临界流体（例如超临界二氧化碳（SC CO 2 2））制备聚合物涂覆的纳米颗粒和/或其它超细颗粒作为可加入的抗溶剂的方法和/或系统 涉及悬浮有不溶性纳米粒子等的聚合物和有机溶剂的溶液。 当超临界流体（例如SC CO 2 H 2）和含纳米颗粒的悬浮液组合以引起悬浮的纳米颗粒作为包覆的纳米颗粒沉淀时，发生涂覆过程。 还描述了用于优化和/或增强涂覆工艺，方法和/或系统的功效和/或效率以及用于控制涂覆颗粒的涂覆和/或附聚的加工参数。 方法，方法和/或系统具有广泛的适用性，例如用于药物，化妆品，食品，化学品，农业化学品，农药，聚合物，涂料，催化剂等的涂覆和/或包封。