公开(公告)号：US07008934B2

公开(公告)日：2006-03-07

申请号：US10183127

申请日：2002-06-26

申请人： Jianwei Yu

发明人： Jianwei Yu

IPC分类号： A61K31/724 ,  A61K31/54

CPC分类号： A61K47/40 ,  A61K9/0019 ,  A61K31/5415 ,  A61K47/26

摘要： Compositions and methods are provided for reducing adverse reactions as a result of parenteral administration of certain phenothiazine derivatives such as promethazine hydrochloride. The active compound may be admixed with an effective amount of one or more cyclodextrin derivatives, and if desired, one or more non-ionic surfactants such as the partial esters of sorbitol and the polyoxyethylene oxides of long chain fatty acids such as the polysorbates.

公开(公告)号：US11065265B2

公开(公告)日：2021-07-20

申请号：US16245992

申请日：2019-01-11

申请人： Jianwei Yu ,  Yulu Wang

发明人： Jianwei Yu ,  Yulu Wang

IPC分类号： A61K31/675 ,  A61K47/40 ,  A61K9/08 ,  A61K9/00 ,  A61K47/18

摘要： The present application and its embodiments teach stable compositions of fosaprepitant or a pharmaceutically acceptable salt thereof with such compositions lacking polysorbate 80 and containing dual functional excipients of hydrolysis inhibition and solubility enhancement. Further described are methods of preparation of such compositions. Among other advantages of contemplated compositions, fosaprepitant hydrolysis degradation is kept low and the compositions maintain physically and chemically stable for prolonged period.

公开(公告)号：US20190350947A1

公开(公告)日：2019-11-21

申请号：US16245992

申请日：2019-01-11

申请人： Jianwei Yu ,  Yulu Wang ,  Qihai Tao

发明人： Jianwei Yu ,  Yulu Wang ,  Qihai Tao

IPC分类号： A61K31/675 ,  A61K47/40 ,  A61K47/18 ,  A61K9/00 ,  A61K9/08

摘要： The present application and its embodiments teach stable compositions of fosaprepitant or a pharmaceutically acceptable salt thereof with such compositions lacking polysorbate 80 and containing dual functional excipients of hydrolysis inhibition and solubility enhancement. Further described are methods of preparation of such compositions. Among other advantages of contemplated compositions, fosaprepitant hydrolysis degradation is kept low and the compositions maintain physically and chemically stable for prolonged period.

公开(公告)号：US07122201B2

公开(公告)日：2006-10-17

申请号：US10183599

申请日：2002-06-26

申请人： Jianwei Yu ,  Pui-Ho Yuen ,  Virginia Paulate

发明人： Jianwei Yu ,  Pui-Ho Yuen ,  Virginia Paulate

IPC分类号： A61F2/02

CPC分类号： A61K47/26 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/183

摘要： Compositions and methods are provided for reducing adverse reactions as a result of parenteral administration of certain phenothiazine derivatives such as promethazine, including promethazine hydrochloride. The active compound may be admixed with an effective amount of one or more non-ionic surfactants and at least one amino acid and/or one polyol prior to administration to an animal such as a mammal.