公开(公告)号：US08470322B2

公开(公告)日：2013-06-25

申请号：US13264105

申请日：2010-05-03

申请人： Cristina Mateo De Acosta Del Rio ,  Ana Maria Vazquez Lopez ,  Alejandro Lopez Requena ,  Yuniel Fernandez Marrero ,  Yosdel Soto Lopez ,  Victor Brito Navarro

发明人： Cristina Mateo De Acosta Del Rio ,  Ana Maria Vazquez Lopez ,  Alejandro Lopez Requena ,  Yuniel Fernandez Marrero ,  Yosdel Soto Lopez ,  Victor Brito Navarro

IPC分类号： A61K39/395 ,  G01N33/53 ,  C07K16/46 ,  C07K16/28

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/24 ,  G01N33/6893 ,  G01N2800/323

摘要： The present invention relates to the biotechnology and particularly with new products for use in human health.The present invention provides new specific monoclonal antibodies, which bind with high affinity sulfatides and sulfated proteoglycans.The anti sulfatides and anti sulfated proteoglycans antibodies disclosed in the present invention and described in the description, provide important diagnostic and therapeutic tools to act on pathological processes associated with the appearance of atherosclerotic plaques.Accordingly, the invention provides pharmaceutical compositions comprising MAbs of the invention or fragments thereof for the therapeutic and diagnostic use associated with cardiovascular diseases. Particularly, the present invention relates to the fragments derived from the MAbs that recognize sulfatides and sulfated proteoglycans, which can be used in the therapy or diagnosis of this pathology.

摘要翻译： 本发明涉及生物技术，尤其涉及用于人类健康的新产品。 本发明提供了新的特异性单克隆抗体，其与高亲和力硫酸酯和硫酸化蛋白多糖结合。 在本发明中公开并描述于本说明书中的抗硫酸酯化物和抗硫酸化蛋白多糖抗体提供了用于与动脉粥样硬化斑块出现相关的病理过程的重要诊断和治疗工具。 因此，本发明提供包含本发明MAb或其片段的用于与心血管疾病相关的治疗和诊断用途的药物组合物。 特别地，本发明涉及来自识别硫酸盐和硫酸化蛋白多糖的MAb的片段，其可用于治疗或诊断该病理学。

公开(公告)号：US20120121605A1

公开(公告)日：2012-05-17

申请号：US13264105

申请日：2010-05-03

申请人： Cristina Mateo De Acosta Del Rio ,  Ana Maria Vazquez Lopez ,  Alejandro Lopez Requena ,  Yuniel Fernandez Marrero ,  Yosdel Soto Lopez ,  Victor Brito Navarro

发明人： Cristina Mateo De Acosta Del Rio ,  Ana Maria Vazquez Lopez ,  Alejandro Lopez Requena ,  Yuniel Fernandez Marrero ,  Yosdel Soto Lopez ,  Victor Brito Navarro

IPC分类号： A61K39/395 ,  A61P9/10 ,  C07K16/18

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/24 ,  G01N33/6893 ,  G01N2800/323

摘要： The present invention relates to the biotechnology and particularly with new products for use in human health.The present invention provides new specific monoclonal antibodies, which bind with high affinity sulfatides and sulfated proteoglycans.The anti sulfatides and anti sulfated proteoglycans antibodies disclosed in the present invention and described in the description, provide important diagnostic and therapeutic tools to act on pathological processes associated with the appearance of atherosclerotic plaques.Accordingly, the invention provides pharmaceutical compositions comprising MAbs of the invention or fragments thereof for the therapeutic and diagnostic use associated with cardiovascular diseases. Particularly, the present invention relates to the fragments derived from the MAbs that recognize sulfatides and sulfated proteoglycans, which can be used in the therapy or diagnosis of this pathology.

摘要翻译： 本发明涉及生物技术，尤其涉及用于人类健康的新产品。 本发明提供了新的特异性单克隆抗体，其与高亲和力硫酸酯和硫酸化蛋白多糖结合。 在本发明中公开并描述于本说明书中的抗硫酸酯化物和抗硫酸化蛋白多糖抗体提供了用于与动脉粥样硬化斑块出现相关的病理过程的重要诊断和治疗工具。 因此，本发明提供包含本发明MAb或其片段的用于与心血管疾病相关的治疗和诊断用途的药物组合物。 特别地，本发明涉及来自识别硫酸盐和硫酸化蛋白多糖的MAb的片段，其可用于治疗或诊断该病理学。